Electrochemical and spectroscopic characterisation of amphetamine-like drugs: Application to the screening of 3,4-methylenedioxymethamphetamine (MDMA) and its synthetic precursors

Detalhes bibliográficos
Autor(a) principal: Milhazes, Nuno
Data de Publicação: 2007
Outros Autores: Martins, Pedro, Uriarte, Eugenio, Garrido, Jorge, Calheiros, Rita, Marques, M. Paula M., Borges, Fernanda
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/3859
https://doi.org/10.1016/j.aca.2007.06.027
Resumo: A complete physicochemical characterisation of MDMA and its synthetic precursors MDA, 3,4-methylenedioxybenzaldehyde (piperonal) and 3,4-methylenedioxy-[beta]-methyl-[beta]-nitrostyrene was carried out through voltammetric assays and Raman spectroscopy combined with theoretical (DFT) calculations. The former provided important analytical redox data, concluding that the oxidative mechanism of the N-demethylation of MDMA involves the removal of an electron from the amino-nitrogen atom, leading to the formation of a primary amine and an aldehyde. The vibrational spectroscopic experiments enable to afford a rapid and reliable detection of this type of compounds, since they yield characteristic spectral patterns that lead to an unequivocal identification.
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spelling Electrochemical and spectroscopic characterisation of amphetamine-like drugs: Application to the screening of 3,4-methylenedioxymethamphetamine (MDMA) and its synthetic precursors3,4-MethylenedioxymethamphetamineSynthesisRaman spectroscopyVoltammetryDensity functional theory calculationsA complete physicochemical characterisation of MDMA and its synthetic precursors MDA, 3,4-methylenedioxybenzaldehyde (piperonal) and 3,4-methylenedioxy-[beta]-methyl-[beta]-nitrostyrene was carried out through voltammetric assays and Raman spectroscopy combined with theoretical (DFT) calculations. The former provided important analytical redox data, concluding that the oxidative mechanism of the N-demethylation of MDMA involves the removal of an electron from the amino-nitrogen atom, leading to the formation of a primary amine and an aldehyde. The vibrational spectroscopic experiments enable to afford a rapid and reliable detection of this type of compounds, since they yield characteristic spectral patterns that lead to an unequivocal identification.http://www.sciencedirect.com/science/article/B6TF4-4P0X5D5-4/1/9762a97e2bf78b805ff2aef86d7a1cc02007info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/3859http://hdl.handle.net/10316/3859https://doi.org/10.1016/j.aca.2007.06.027engAnalytica Chimica Acta. 596:2 (2007) 231-241Milhazes, NunoMartins, PedroUriarte, EugenioGarrido, JorgeCalheiros, RitaMarques, M. Paula M.Borges, Fernandainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-11-04T17:11:46Zoai:estudogeral.uc.pt:10316/3859Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:55:45.041099Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Electrochemical and spectroscopic characterisation of amphetamine-like drugs: Application to the screening of 3,4-methylenedioxymethamphetamine (MDMA) and its synthetic precursors
title Electrochemical and spectroscopic characterisation of amphetamine-like drugs: Application to the screening of 3,4-methylenedioxymethamphetamine (MDMA) and its synthetic precursors
spellingShingle Electrochemical and spectroscopic characterisation of amphetamine-like drugs: Application to the screening of 3,4-methylenedioxymethamphetamine (MDMA) and its synthetic precursors
Milhazes, Nuno
3,4-Methylenedioxymethamphetamine
Synthesis
Raman spectroscopy
Voltammetry
Density functional theory calculations
title_short Electrochemical and spectroscopic characterisation of amphetamine-like drugs: Application to the screening of 3,4-methylenedioxymethamphetamine (MDMA) and its synthetic precursors
title_full Electrochemical and spectroscopic characterisation of amphetamine-like drugs: Application to the screening of 3,4-methylenedioxymethamphetamine (MDMA) and its synthetic precursors
title_fullStr Electrochemical and spectroscopic characterisation of amphetamine-like drugs: Application to the screening of 3,4-methylenedioxymethamphetamine (MDMA) and its synthetic precursors
title_full_unstemmed Electrochemical and spectroscopic characterisation of amphetamine-like drugs: Application to the screening of 3,4-methylenedioxymethamphetamine (MDMA) and its synthetic precursors
title_sort Electrochemical and spectroscopic characterisation of amphetamine-like drugs: Application to the screening of 3,4-methylenedioxymethamphetamine (MDMA) and its synthetic precursors
author Milhazes, Nuno
author_facet Milhazes, Nuno
Martins, Pedro
Uriarte, Eugenio
Garrido, Jorge
Calheiros, Rita
Marques, M. Paula M.
Borges, Fernanda
author_role author
author2 Martins, Pedro
Uriarte, Eugenio
Garrido, Jorge
Calheiros, Rita
Marques, M. Paula M.
Borges, Fernanda
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Milhazes, Nuno
Martins, Pedro
Uriarte, Eugenio
Garrido, Jorge
Calheiros, Rita
Marques, M. Paula M.
Borges, Fernanda
dc.subject.por.fl_str_mv 3,4-Methylenedioxymethamphetamine
Synthesis
Raman spectroscopy
Voltammetry
Density functional theory calculations
topic 3,4-Methylenedioxymethamphetamine
Synthesis
Raman spectroscopy
Voltammetry
Density functional theory calculations
description A complete physicochemical characterisation of MDMA and its synthetic precursors MDA, 3,4-methylenedioxybenzaldehyde (piperonal) and 3,4-methylenedioxy-[beta]-methyl-[beta]-nitrostyrene was carried out through voltammetric assays and Raman spectroscopy combined with theoretical (DFT) calculations. The former provided important analytical redox data, concluding that the oxidative mechanism of the N-demethylation of MDMA involves the removal of an electron from the amino-nitrogen atom, leading to the formation of a primary amine and an aldehyde. The vibrational spectroscopic experiments enable to afford a rapid and reliable detection of this type of compounds, since they yield characteristic spectral patterns that lead to an unequivocal identification.
publishDate 2007
dc.date.none.fl_str_mv 2007
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/3859
http://hdl.handle.net/10316/3859
https://doi.org/10.1016/j.aca.2007.06.027
url http://hdl.handle.net/10316/3859
https://doi.org/10.1016/j.aca.2007.06.027
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Analytica Chimica Acta. 596:2 (2007) 231-241
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv aplication/PDF
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