The mitogenome portrait of Umbria in Central Italy as depicted by contemporary inhabitants and pre-Roman remains
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/143513 |
Resumo: | Umbria is located in Central Italy and took the name from its ancient inhabitants, the Umbri, whose origins are still debated. Here, we investigated the mitochondrial DNA (mtDNA) variation of 545 present-day Umbrians (with 198 entire mitogenomes) and 28 pre-Roman individuals (obtaining 19 ancient mtDNAs) excavated from the necropolis of Plestia. We found a rather homogeneous distribution of western Eurasian lineages across the region, with few notable exceptions. Contemporary inhabitants of the eastern part, delimited by the Tiber River and the Apennine Mountains, manifest a peculiar mitochondrial proximity to central-eastern Europeans, mainly due to haplogroups U4 and U5a, and an overrepresentation of J (30%) similar to the pre-Roman remains, also excavated in East Umbria. Local genetic continuities are further attested to by six terminal branches (H1e1, J1c3, J2b1, U2e2a, U8b1b1 and K1a4a) shared between ancient and modern mitogenomes. Eventually, we identified multiple inputs from various population sources that likely shaped the mitochondrial gene pool of ancient Umbri over time, since early Neolithic, including gene flows with central-eastern Europe. This diachronic mtDNA portrait of Umbria fits well with the genome-wide population structure identified on the entire peninsula and with historical sources that list the Umbri among the most ancient Italic populations. |
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The mitogenome portrait of Umbria in Central Italy as depicted by contemporary inhabitants and pre-Roman remainsUmbria is located in Central Italy and took the name from its ancient inhabitants, the Umbri, whose origins are still debated. Here, we investigated the mitochondrial DNA (mtDNA) variation of 545 present-day Umbrians (with 198 entire mitogenomes) and 28 pre-Roman individuals (obtaining 19 ancient mtDNAs) excavated from the necropolis of Plestia. We found a rather homogeneous distribution of western Eurasian lineages across the region, with few notable exceptions. Contemporary inhabitants of the eastern part, delimited by the Tiber River and the Apennine Mountains, manifest a peculiar mitochondrial proximity to central-eastern Europeans, mainly due to haplogroups U4 and U5a, and an overrepresentation of J (30%) similar to the pre-Roman remains, also excavated in East Umbria. Local genetic continuities are further attested to by six terminal branches (H1e1, J1c3, J2b1, U2e2a, U8b1b1 and K1a4a) shared between ancient and modern mitogenomes. Eventually, we identified multiple inputs from various population sources that likely shaped the mitochondrial gene pool of ancient Umbri over time, since early Neolithic, including gene flows with central-eastern Europe. This diachronic mtDNA portrait of Umbria fits well with the genome-wide population structure identified on the entire peninsula and with historical sources that list the Umbri among the most ancient Italic populations.Nature Publishing Group20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/143513eng2045-232210.1038/s41598-020-67445-0Modi, ALancioni, HCardinali, ICapodiferro, MRRambaldi Migliore, NHussein, AStrobl, CBodner, MSchnaller, LXavier, CRizzi, EBonomi Ponzi, LVai, SRaveane, ACavadas, BSemino, OTorroni, AOlivieri, ALari, MPereira, LParson, WCaramelli, DAchilli, Ainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T13:09:10Zoai:repositorio-aberto.up.pt:10216/143513Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:34:36.889323Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The mitogenome portrait of Umbria in Central Italy as depicted by contemporary inhabitants and pre-Roman remains |
title |
The mitogenome portrait of Umbria in Central Italy as depicted by contemporary inhabitants and pre-Roman remains |
spellingShingle |
The mitogenome portrait of Umbria in Central Italy as depicted by contemporary inhabitants and pre-Roman remains Modi, A |
title_short |
The mitogenome portrait of Umbria in Central Italy as depicted by contemporary inhabitants and pre-Roman remains |
title_full |
The mitogenome portrait of Umbria in Central Italy as depicted by contemporary inhabitants and pre-Roman remains |
title_fullStr |
The mitogenome portrait of Umbria in Central Italy as depicted by contemporary inhabitants and pre-Roman remains |
title_full_unstemmed |
The mitogenome portrait of Umbria in Central Italy as depicted by contemporary inhabitants and pre-Roman remains |
title_sort |
The mitogenome portrait of Umbria in Central Italy as depicted by contemporary inhabitants and pre-Roman remains |
author |
Modi, A |
author_facet |
Modi, A Lancioni, H Cardinali, I Capodiferro, MR Rambaldi Migliore, N Hussein, A Strobl, C Bodner, M Schnaller, L Xavier, C Rizzi, E Bonomi Ponzi, L Vai, S Raveane, A Cavadas, B Semino, O Torroni, A Olivieri, A Lari, M Pereira, L Parson, W Caramelli, D Achilli, A |
author_role |
author |
author2 |
Lancioni, H Cardinali, I Capodiferro, MR Rambaldi Migliore, N Hussein, A Strobl, C Bodner, M Schnaller, L Xavier, C Rizzi, E Bonomi Ponzi, L Vai, S Raveane, A Cavadas, B Semino, O Torroni, A Olivieri, A Lari, M Pereira, L Parson, W Caramelli, D Achilli, A |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Modi, A Lancioni, H Cardinali, I Capodiferro, MR Rambaldi Migliore, N Hussein, A Strobl, C Bodner, M Schnaller, L Xavier, C Rizzi, E Bonomi Ponzi, L Vai, S Raveane, A Cavadas, B Semino, O Torroni, A Olivieri, A Lari, M Pereira, L Parson, W Caramelli, D Achilli, A |
description |
Umbria is located in Central Italy and took the name from its ancient inhabitants, the Umbri, whose origins are still debated. Here, we investigated the mitochondrial DNA (mtDNA) variation of 545 present-day Umbrians (with 198 entire mitogenomes) and 28 pre-Roman individuals (obtaining 19 ancient mtDNAs) excavated from the necropolis of Plestia. We found a rather homogeneous distribution of western Eurasian lineages across the region, with few notable exceptions. Contemporary inhabitants of the eastern part, delimited by the Tiber River and the Apennine Mountains, manifest a peculiar mitochondrial proximity to central-eastern Europeans, mainly due to haplogroups U4 and U5a, and an overrepresentation of J (30%) similar to the pre-Roman remains, also excavated in East Umbria. Local genetic continuities are further attested to by six terminal branches (H1e1, J1c3, J2b1, U2e2a, U8b1b1 and K1a4a) shared between ancient and modern mitogenomes. Eventually, we identified multiple inputs from various population sources that likely shaped the mitochondrial gene pool of ancient Umbri over time, since early Neolithic, including gene flows with central-eastern Europe. This diachronic mtDNA portrait of Umbria fits well with the genome-wide population structure identified on the entire peninsula and with historical sources that list the Umbri among the most ancient Italic populations. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020 2020-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/143513 |
url |
https://hdl.handle.net/10216/143513 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2045-2322 10.1038/s41598-020-67445-0 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799135657948348416 |