Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/106469 https://doi.org/10.3390/molecules25071607 |
Resumo: | Novel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of TZ-PORs as photosensitizers, the phototoxicity of the formulations towards cancer cells was screened. Biological studies show high photodynamic activity of all PVP-TZ-POR formulations against a bladder cancer cell line with a particular highlight to PVP-TZ-POR 7e and 7f that are able to significantly reduce HT-1376 cell viability, while they had no effect on control ARPE-19 cells. |
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Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivativesporphyrintriazolepolyvinylpyrrolidonephotodynamic therapyhuman bladder cancer cellshuman retinal pigment epithelial cellsNovel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of TZ-PORs as photosensitizers, the phototoxicity of the formulations towards cancer cells was screened. Biological studies show high photodynamic activity of all PVP-TZ-POR formulations against a bladder cancer cell line with a particular highlight to PVP-TZ-POR 7e and 7f that are able to significantly reduce HT-1376 cell viability, while they had no effect on control ARPE-19 cells.The authors are grateful to University of Aveiro and FCT/MCT for the financial support for QOPNA research Unit (FCT UID/QUI/00062/2019) and LAQV-REQUIMTE (UIDB/50006/2020) through national funds. Thanks are also due to FCT/MCT for the financial support of iCBR and CIBB units (TDC/QEQQOR/1273/2012; UID/NEU/04539/2019 FCT UID/QUI/00062/2013) and CQE unit (UIDB/00100/2020), COMPETE-FEDER (POCI-01-0145-FEDER-007440) and Centro 2020 Regional Operational Programme: HEALTHYAGING 2020 (CENTRO-01-0145-FEDER-000012) for funding. Ana Gomes also thanks FCT for the post-doctoral grant (SFRH/BPD/79521/2011).MDPI2020-03-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/106469http://hdl.handle.net/10316/106469https://doi.org/10.3390/molecules25071607eng1420-3049322445141420-3049Gomes, Ana T. P. C.Fernandes, RosaRibeiro, Carlos F. M.Tomé, João P. C.Neves, Maria G. P. M. S.Silva, Fernando de C. daFerreira, Vítor F.Cavaleiro, José A. S.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-04-06T10:20:12Zoai:estudogeral.uc.pt:10316/106469Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:22:55.196681Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives |
title |
Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives |
spellingShingle |
Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives Gomes, Ana T. P. C. porphyrin triazole polyvinylpyrrolidone photodynamic therapy human bladder cancer cells human retinal pigment epithelial cells |
title_short |
Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives |
title_full |
Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives |
title_fullStr |
Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives |
title_full_unstemmed |
Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives |
title_sort |
Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives |
author |
Gomes, Ana T. P. C. |
author_facet |
Gomes, Ana T. P. C. Fernandes, Rosa Ribeiro, Carlos F. M. Tomé, João P. C. Neves, Maria G. P. M. S. Silva, Fernando de C. da Ferreira, Vítor F. Cavaleiro, José A. S. |
author_role |
author |
author2 |
Fernandes, Rosa Ribeiro, Carlos F. M. Tomé, João P. C. Neves, Maria G. P. M. S. Silva, Fernando de C. da Ferreira, Vítor F. Cavaleiro, José A. S. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Gomes, Ana T. P. C. Fernandes, Rosa Ribeiro, Carlos F. M. Tomé, João P. C. Neves, Maria G. P. M. S. Silva, Fernando de C. da Ferreira, Vítor F. Cavaleiro, José A. S. |
dc.subject.por.fl_str_mv |
porphyrin triazole polyvinylpyrrolidone photodynamic therapy human bladder cancer cells human retinal pigment epithelial cells |
topic |
porphyrin triazole polyvinylpyrrolidone photodynamic therapy human bladder cancer cells human retinal pigment epithelial cells |
description |
Novel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of TZ-PORs as photosensitizers, the phototoxicity of the formulations towards cancer cells was screened. Biological studies show high photodynamic activity of all PVP-TZ-POR formulations against a bladder cancer cell line with a particular highlight to PVP-TZ-POR 7e and 7f that are able to significantly reduce HT-1376 cell viability, while they had no effect on control ARPE-19 cells. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-03-31 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/106469 http://hdl.handle.net/10316/106469 https://doi.org/10.3390/molecules25071607 |
url |
http://hdl.handle.net/10316/106469 https://doi.org/10.3390/molecules25071607 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1420-3049 32244514 1420-3049 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134117287165952 |