Proteomics-based identification of salivary changes in patients with burning mouth syndrome
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10174/31808 https://doi.org/10.3390/biology10050392 |
Resumo: | Burning mouth syndrome (BMS) is a chronic oral condition characterized by an intraoral burning sensation, taste alterations, and dry mouth sensations. Although a number of factors have been closely related to the appearance of the symptoms, including anxiety, depression, and sleep disturbances, the etiology of BMS remains unclear. Furthermore, currently no objective diagnostic tools exist, making its diagnosis challenging. Therefore, to contribute to the knowledge about BMS etiology and look for objective tools for its diagnosis, the present study was conducted. Thus, the aim of this study was to analyze the proteomic profile of the resting whole saliva of patients with BMS and age and sex-matched controls using two-dimensional electrophoresis. The results showed evidence of changes in saliva at the level of proteins related to important pathways such as stress (sAA), immune system (Ig), and inflammation (leukocyte elastase inhibitor). While some of our findings have been previously described others, such as the deregulation of the coiled-coin domain containing protein 25 in BMS, are presented here for the first time to our knowledge. Thus, saliva provides us with relevant information about BMS pathophysiology and could be considered a suitable biofluid for its study and/or diagnosis |
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Proteomics-based identification of salivary changes in patients with burning mouth syndromeBurning mouthSalivaProteomicsBurning mouth syndrome (BMS) is a chronic oral condition characterized by an intraoral burning sensation, taste alterations, and dry mouth sensations. Although a number of factors have been closely related to the appearance of the symptoms, including anxiety, depression, and sleep disturbances, the etiology of BMS remains unclear. Furthermore, currently no objective diagnostic tools exist, making its diagnosis challenging. Therefore, to contribute to the knowledge about BMS etiology and look for objective tools for its diagnosis, the present study was conducted. Thus, the aim of this study was to analyze the proteomic profile of the resting whole saliva of patients with BMS and age and sex-matched controls using two-dimensional electrophoresis. The results showed evidence of changes in saliva at the level of proteins related to important pathways such as stress (sAA), immune system (Ig), and inflammation (leukocyte elastase inhibitor). While some of our findings have been previously described others, such as the deregulation of the coiled-coin domain containing protein 25 in BMS, are presented here for the first time to our knowledge. Thus, saliva provides us with relevant information about BMS pathophysiology and could be considered a suitable biofluid for its study and/or diagnosisMDPI2022-04-26T14:45:42Z2022-04-262021-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/31808http://hdl.handle.net/10174/31808https://doi.org/10.3390/biology10050392engCastillo-Felipe, C., Franco-Martínez, L., Tvarijonaviciute, A., Lopez-Jornet, P., & Lamy, E. (2021). Proteomics-based identification of salivary changes in patients with burning mouth syndrome. Biology, 10(5), 392.https://www.mdpi.com/2079-7737/10/5/392ndndndndecsl@uevora.pt548Castillo-Felipe, CandelaFranco-Martínez, LorenaTvarijonaviciute, AstaLopez-Jornet, PiaLamy, Elsainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T19:31:37Zoai:dspace.uevora.pt:10174/31808Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:20:50.260659Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Proteomics-based identification of salivary changes in patients with burning mouth syndrome |
title |
Proteomics-based identification of salivary changes in patients with burning mouth syndrome |
spellingShingle |
Proteomics-based identification of salivary changes in patients with burning mouth syndrome Castillo-Felipe, Candela Burning mouth Saliva Proteomics |
title_short |
Proteomics-based identification of salivary changes in patients with burning mouth syndrome |
title_full |
Proteomics-based identification of salivary changes in patients with burning mouth syndrome |
title_fullStr |
Proteomics-based identification of salivary changes in patients with burning mouth syndrome |
title_full_unstemmed |
Proteomics-based identification of salivary changes in patients with burning mouth syndrome |
title_sort |
Proteomics-based identification of salivary changes in patients with burning mouth syndrome |
author |
Castillo-Felipe, Candela |
author_facet |
Castillo-Felipe, Candela Franco-Martínez, Lorena Tvarijonaviciute, Asta Lopez-Jornet, Pia Lamy, Elsa |
author_role |
author |
author2 |
Franco-Martínez, Lorena Tvarijonaviciute, Asta Lopez-Jornet, Pia Lamy, Elsa |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Castillo-Felipe, Candela Franco-Martínez, Lorena Tvarijonaviciute, Asta Lopez-Jornet, Pia Lamy, Elsa |
dc.subject.por.fl_str_mv |
Burning mouth Saliva Proteomics |
topic |
Burning mouth Saliva Proteomics |
description |
Burning mouth syndrome (BMS) is a chronic oral condition characterized by an intraoral burning sensation, taste alterations, and dry mouth sensations. Although a number of factors have been closely related to the appearance of the symptoms, including anxiety, depression, and sleep disturbances, the etiology of BMS remains unclear. Furthermore, currently no objective diagnostic tools exist, making its diagnosis challenging. Therefore, to contribute to the knowledge about BMS etiology and look for objective tools for its diagnosis, the present study was conducted. Thus, the aim of this study was to analyze the proteomic profile of the resting whole saliva of patients with BMS and age and sex-matched controls using two-dimensional electrophoresis. The results showed evidence of changes in saliva at the level of proteins related to important pathways such as stress (sAA), immune system (Ig), and inflammation (leukocyte elastase inhibitor). While some of our findings have been previously described others, such as the deregulation of the coiled-coin domain containing protein 25 in BMS, are presented here for the first time to our knowledge. Thus, saliva provides us with relevant information about BMS pathophysiology and could be considered a suitable biofluid for its study and/or diagnosis |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-05-01T00:00:00Z 2022-04-26T14:45:42Z 2022-04-26 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10174/31808 http://hdl.handle.net/10174/31808 https://doi.org/10.3390/biology10050392 |
url |
http://hdl.handle.net/10174/31808 https://doi.org/10.3390/biology10050392 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Castillo-Felipe, C., Franco-Martínez, L., Tvarijonaviciute, A., Lopez-Jornet, P., & Lamy, E. (2021). Proteomics-based identification of salivary changes in patients with burning mouth syndrome. Biology, 10(5), 392. https://www.mdpi.com/2079-7737/10/5/392 nd nd nd nd ecsl@uevora.pt 548 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799136689633886208 |