Radiochemical and biological evaluation of novel Sm-153/Ho-166-amino acid-chitosan complexes
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/82122 |
Resumo: | Sm-153/Ho-166-chitosan complexes have been considered promising agents for internal radiation therapy. By direct administration, complexes solution converts into a gel, at physiological pH, allowing its retention for a long time. Herein, we report on the synthesis of Sm-153/Ho-166 complexes with the novel amino acid-chitosan polymers, N-(gamma-propanoylvalin)-chitosan (CHICO-val) and N-(gamma-propanoyl-aspartic acid)-chitosan (CHICO-asp). The main goal of this study was to obtain data on the radiochemical and biological behaviour of these complexes and information regarding their therapeutic potential when compared to Sm-153/Ho-166-chitosan. Radiolabelling yield of Sm-153/Ho-166-amino acid-chitosan complexes was dependent on polymer concentration but less dependent on pH. Radiochemical stability was shown to be higher for amino acid-chitosans than for chitosan, with Sm-153/Ho-166-CHICO-val being stable up to 3 h, while Sm-153/Ho-166-CHICO-asp is stable up to 24 h. In the presence of ascorbic acid radiochemical stability of Sm-153/Ho-166-CHICO-val and Sm-153/Ho-166-CHICO was improved, decreasing for Sm-153/Ho-166-CHICO-asp. In vivo behaviour of Sm-153 complexes was studied in mice. The radioactive amino acid-chitosans can be directly injected into blood stream without significant retention on injection site, being trapped by liver. Biodistribution studies suggest that the radioactive amino acid-chitosans, due to its water solubility and stability may be considered potential candidates to be further explored for liver targeted nuclear therapy. |
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Radiochemical and biological evaluation of novel Sm-153/Ho-166-amino acid-chitosan complexesQuímicaChemical sciencesSm-153/Ho-166-chitosan complexes have been considered promising agents for internal radiation therapy. By direct administration, complexes solution converts into a gel, at physiological pH, allowing its retention for a long time. Herein, we report on the synthesis of Sm-153/Ho-166 complexes with the novel amino acid-chitosan polymers, N-(gamma-propanoylvalin)-chitosan (CHICO-val) and N-(gamma-propanoyl-aspartic acid)-chitosan (CHICO-asp). The main goal of this study was to obtain data on the radiochemical and biological behaviour of these complexes and information regarding their therapeutic potential when compared to Sm-153/Ho-166-chitosan. Radiolabelling yield of Sm-153/Ho-166-amino acid-chitosan complexes was dependent on polymer concentration but less dependent on pH. Radiochemical stability was shown to be higher for amino acid-chitosans than for chitosan, with Sm-153/Ho-166-CHICO-val being stable up to 3 h, while Sm-153/Ho-166-CHICO-asp is stable up to 24 h. In the presence of ascorbic acid radiochemical stability of Sm-153/Ho-166-CHICO-val and Sm-153/Ho-166-CHICO was improved, decreasing for Sm-153/Ho-166-CHICO-asp. In vivo behaviour of Sm-153 complexes was studied in mice. The radioactive amino acid-chitosans can be directly injected into blood stream without significant retention on injection site, being trapped by liver. Biodistribution studies suggest that the radioactive amino acid-chitosans, due to its water solubility and stability may be considered potential candidates to be further explored for liver targeted nuclear therapy.20092009-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/82122eng0362-480310.1002/jlcr.1571Marques, FGano, LBatista, MKSGomes, CARGomes, PSantos, Iinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T16:14:02Zoai:repositorio-aberto.up.pt:10216/82122Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:39:31.660642Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Radiochemical and biological evaluation of novel Sm-153/Ho-166-amino acid-chitosan complexes |
title |
Radiochemical and biological evaluation of novel Sm-153/Ho-166-amino acid-chitosan complexes |
spellingShingle |
Radiochemical and biological evaluation of novel Sm-153/Ho-166-amino acid-chitosan complexes Marques, F Química Chemical sciences |
title_short |
Radiochemical and biological evaluation of novel Sm-153/Ho-166-amino acid-chitosan complexes |
title_full |
Radiochemical and biological evaluation of novel Sm-153/Ho-166-amino acid-chitosan complexes |
title_fullStr |
Radiochemical and biological evaluation of novel Sm-153/Ho-166-amino acid-chitosan complexes |
title_full_unstemmed |
Radiochemical and biological evaluation of novel Sm-153/Ho-166-amino acid-chitosan complexes |
title_sort |
Radiochemical and biological evaluation of novel Sm-153/Ho-166-amino acid-chitosan complexes |
author |
Marques, F |
author_facet |
Marques, F Gano, L Batista, MKS Gomes, CAR Gomes, P Santos, I |
author_role |
author |
author2 |
Gano, L Batista, MKS Gomes, CAR Gomes, P Santos, I |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Marques, F Gano, L Batista, MKS Gomes, CAR Gomes, P Santos, I |
dc.subject.por.fl_str_mv |
Química Chemical sciences |
topic |
Química Chemical sciences |
description |
Sm-153/Ho-166-chitosan complexes have been considered promising agents for internal radiation therapy. By direct administration, complexes solution converts into a gel, at physiological pH, allowing its retention for a long time. Herein, we report on the synthesis of Sm-153/Ho-166 complexes with the novel amino acid-chitosan polymers, N-(gamma-propanoylvalin)-chitosan (CHICO-val) and N-(gamma-propanoyl-aspartic acid)-chitosan (CHICO-asp). The main goal of this study was to obtain data on the radiochemical and biological behaviour of these complexes and information regarding their therapeutic potential when compared to Sm-153/Ho-166-chitosan. Radiolabelling yield of Sm-153/Ho-166-amino acid-chitosan complexes was dependent on polymer concentration but less dependent on pH. Radiochemical stability was shown to be higher for amino acid-chitosans than for chitosan, with Sm-153/Ho-166-CHICO-val being stable up to 3 h, while Sm-153/Ho-166-CHICO-asp is stable up to 24 h. In the presence of ascorbic acid radiochemical stability of Sm-153/Ho-166-CHICO-val and Sm-153/Ho-166-CHICO was improved, decreasing for Sm-153/Ho-166-CHICO-asp. In vivo behaviour of Sm-153 complexes was studied in mice. The radioactive amino acid-chitosans can be directly injected into blood stream without significant retention on injection site, being trapped by liver. Biodistribution studies suggest that the radioactive amino acid-chitosans, due to its water solubility and stability may be considered potential candidates to be further explored for liver targeted nuclear therapy. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009 2009-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/82122 |
url |
https://hdl.handle.net/10216/82122 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0362-4803 10.1002/jlcr.1571 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799136301822246912 |