Differential early subcortical involvement in genetic FTD within the GENFI cohort
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.16/2849 |
Resumo: | Background: Studies have previously shown evidence for presymptomatic cortical atrophy in genetic FTD. Whilst initial investigations have also identified early deep grey matter volume loss, little is known about the extent of subcortical involvement, particularly within subregions, and how this differs between genetic groups. Methods: 480 mutation carriers from the Genetic FTD Initiative (GENFI) were included (198 GRN, 202 C9orf72, 80 MAPT), together with 298 non-carrier cognitively normal controls. Cortical and subcortical volumes of interest were generated using automated parcellation methods on volumetric 3 T T1-weighted MRI scans. Mutation carriers were divided into three disease stages based on their global CDR® plus NACC FTLD score: asymptomatic (0), possibly or mildly symptomatic (0.5) and fully symptomatic (1 or more). Results: In all three groups, subcortical involvement was seen at the CDR 0.5 stage prior to phenoconversion, whereas in the C9orf72 and MAPT mutation carriers there was also involvement at the CDR 0 stage. In the C9orf72 expansion carriers the earliest volume changes were in thalamic subnuclei (particularly pulvinar and lateral geniculate, 9-10%) cerebellum (lobules VIIa-Crus II and VIIIb, 2-3%), hippocampus (particularly presubiculum and CA1, 2-3%), amygdala (all subregions, 2-6%) and hypothalamus (superior tuberal region, 1%). In MAPT mutation carriers changes were seen at CDR 0 in the hippocampus (subiculum, presubiculum and tail, 3-4%) and amygdala (accessory basal and superficial nuclei, 2-4%). GRN mutation carriers showed subcortical differences at CDR 0.5 in the presubiculum of the hippocampus (8%). Conclusions: C9orf72 expansion carriers show the earliest and most widespread changes including the thalamus, basal ganglia and medial temporal lobe. By investigating individual subregions, changes can also be seen at CDR 0 in MAPT mutation carriers within the limbic system. Our results suggest that subcortical brain volumes may be used as markers of neurodegeneration even prior to the onset of prodromal symptoms. |
id |
RCAP_2227020fe1cf15589a5c69957547fa24 |
---|---|
oai_identifier_str |
oai:repositorio.chporto.pt:10400.16/2849 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Differential early subcortical involvement in genetic FTD within the GENFI cohortBrain volumetryGenetic frontotemporal dementiaMRI imagingPresymptomatic stageBackground: Studies have previously shown evidence for presymptomatic cortical atrophy in genetic FTD. Whilst initial investigations have also identified early deep grey matter volume loss, little is known about the extent of subcortical involvement, particularly within subregions, and how this differs between genetic groups. Methods: 480 mutation carriers from the Genetic FTD Initiative (GENFI) were included (198 GRN, 202 C9orf72, 80 MAPT), together with 298 non-carrier cognitively normal controls. Cortical and subcortical volumes of interest were generated using automated parcellation methods on volumetric 3 T T1-weighted MRI scans. Mutation carriers were divided into three disease stages based on their global CDR® plus NACC FTLD score: asymptomatic (0), possibly or mildly symptomatic (0.5) and fully symptomatic (1 or more). Results: In all three groups, subcortical involvement was seen at the CDR 0.5 stage prior to phenoconversion, whereas in the C9orf72 and MAPT mutation carriers there was also involvement at the CDR 0 stage. In the C9orf72 expansion carriers the earliest volume changes were in thalamic subnuclei (particularly pulvinar and lateral geniculate, 9-10%) cerebellum (lobules VIIa-Crus II and VIIIb, 2-3%), hippocampus (particularly presubiculum and CA1, 2-3%), amygdala (all subregions, 2-6%) and hypothalamus (superior tuberal region, 1%). In MAPT mutation carriers changes were seen at CDR 0 in the hippocampus (subiculum, presubiculum and tail, 3-4%) and amygdala (accessory basal and superficial nuclei, 2-4%). GRN mutation carriers showed subcortical differences at CDR 0.5 in the presubiculum of the hippocampus (8%). Conclusions: C9orf72 expansion carriers show the earliest and most widespread changes including the thalamus, basal ganglia and medial temporal lobe. By investigating individual subregions, changes can also be seen at CDR 0 in MAPT mutation carriers within the limbic system. Our results suggest that subcortical brain volumes may be used as markers of neurodegeneration even prior to the onset of prodromal symptoms.ElsevierRepositório Científico do Centro Hospitalar Universitário de Santo AntónioBocchetta, MartinaTodd, Emily G.Peakman, GeorgiaCash, David M.Convery, Rhian S.Russell, Lucy L.Thomas, David L.Eugenio Iglesias, Juanvan Swieten, John C.Jiskoot, Lize C.Seelaar, HarroBorroni, BarbaraGalimberti, DanielaSanchez-Valle, RaquelLaforce, RobertMoreno, FerminSynofzik, MatthisGraff, CarolineMasellis, MarioCarmela Tartaglia, MariaRowe, James B.Vandenberghe, RikFinger, ElizabethTagliavini, Fabriziode Mendonça, AlexandreSantana, IsabelButler, Chris R.Ducharme, SimonGerhard, AlexanderDanek, AdrianLevin, JohannesOtto, MarkusSorbi, SandroLe Ber, IsabellePasquier, FlorenceRohrer, Jonathan D.Afonso, SóniaRosario Almeida, MariaAnderl-Straub, SarahAndersson, ChristinAntonell, AnnaArchetti, SilvanaArighi, AndreaBalasa, MirceaBarandiaran, MyriamBargalló, NuriaBartha, RobartBender, BenjaminBenussi, AlbertoBertoux, MaximeBertrand, AnneBessi, ValentinaBlack, SandraBorrego-Ecija, SergiBras, JoseBrice, AlexisBruffaerts, RoseCamuzat, AgnèsCañada, MartaCantoni, ValentinaCaroppo, PaolaCastelo-Branco, MiguelColliot, OlivierCope, ThomasDeramecourt, Vincentde Arriba, MaríaDi Fede, GiuseppeDíez, AlinaDuro, DianaFenoglio, ChiaraFerrari, CamillaFerreira, Catarina B.Fox, NickFreedman, MorrisFumagalli, GiorgioFunkiewiez, AurélieGabilondo, AlazneGasparotti, RobertoGauthier, SergeGazzina, StefanoGiaccone, GiorgioGorostidi, AnaGreaves, CarolineGuerreiro, RitaHeller, CarolinHoegen, TobiasIndakoetxea, BegoñaJelic, VesnaKarnath, Hans-OttoKeren, RonKuchcinski, GregoryLangheinrich, TobiasLebouvier, ThibaudJoão Leitão, MariaLladó, AlbertLombardi, GemmaLoosli, SandraMaruta, CarolinaMead, SimonMeeter, LiekeMiltenberger, Gabrielvan Minkelen, RickMitchell, SaraMoore, KatrinaNacmias, BenedettaNelson, AnnabelNicholas, JenniferÖijerstedt, LinnOlives, JaumeOurselin, SebastienPadovani, AlessandroPanman, JessicaPapma, Janne M.Pijnenburg, YolandePolito, CristinaPremi, EnricoPrioni, SaraPrix, CatharinaRademakers, RosaRedaelli, VeronicaRinaldi, DaisyRittman, TimRogaeva, EkaterinaRollin, AdelineRosa-Neto, PedroRossi, GiacominaRossor, MartinSantiago, BeatrizSaracino, DarioSayah, SabrinaScarpini, ElioSchönecker, SonjaSemler, ElisaShafei, RachelleShoesmith, ChristenSwift, ImogenTábuas-Pereira, MiguelTainta, MikelTaipa, RicardoTang-Wai, DavidThompson, PaulThonberg, HakanTimberlake, CarolynTiraboschi, PietroVan Damme, PhilipVandenbulcke, MathieuVeldsman, MicheleVerdelho, AnaVillanua, JorgeWarren, JasonWilke, CarloWoollacott, IoneWlasich, ElisabethZetterberg, HenrikZulaica, Miren2023-10-24T11:46:59Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/2849engBocchetta M, Todd EG, Peakman G, et al. Differential early subcortical involvement in genetic FTD within the GENFI cohort. Neuroimage Clin. 2021;30:102646. doi:10.1016/j.nicl.2021.1026462213-158210.1016/j.nicl.2021.102646info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-26T05:19:20Zoai:repositorio.chporto.pt:10400.16/2849Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:39:39.877790Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Differential early subcortical involvement in genetic FTD within the GENFI cohort |
title |
Differential early subcortical involvement in genetic FTD within the GENFI cohort |
spellingShingle |
Differential early subcortical involvement in genetic FTD within the GENFI cohort Bocchetta, Martina Brain volumetry Genetic frontotemporal dementia MRI imaging Presymptomatic stage |
title_short |
Differential early subcortical involvement in genetic FTD within the GENFI cohort |
title_full |
Differential early subcortical involvement in genetic FTD within the GENFI cohort |
title_fullStr |
Differential early subcortical involvement in genetic FTD within the GENFI cohort |
title_full_unstemmed |
Differential early subcortical involvement in genetic FTD within the GENFI cohort |
title_sort |
Differential early subcortical involvement in genetic FTD within the GENFI cohort |
author |
Bocchetta, Martina |
author_facet |
Bocchetta, Martina Todd, Emily G. Peakman, Georgia Cash, David M. Convery, Rhian S. Russell, Lucy L. Thomas, David L. Eugenio Iglesias, Juan van Swieten, John C. Jiskoot, Lize C. Seelaar, Harro Borroni, Barbara Galimberti, Daniela Sanchez-Valle, Raquel Laforce, Robert Moreno, Fermin Synofzik, Matthis Graff, Caroline Masellis, Mario Carmela Tartaglia, Maria Rowe, James B. Vandenberghe, Rik Finger, Elizabeth Tagliavini, Fabrizio de Mendonça, Alexandre Santana, Isabel Butler, Chris R. Ducharme, Simon Gerhard, Alexander Danek, Adrian Levin, Johannes Otto, Markus Sorbi, Sandro Le Ber, Isabelle Pasquier, Florence Rohrer, Jonathan D. Afonso, Sónia Rosario Almeida, Maria Anderl-Straub, Sarah Andersson, Christin Antonell, Anna Archetti, Silvana Arighi, Andrea Balasa, Mircea Barandiaran, Myriam Bargalló, Nuria Bartha, Robart Bender, Benjamin Benussi, Alberto Bertoux, Maxime Bertrand, Anne Bessi, Valentina Black, Sandra Borrego-Ecija, Sergi Bras, Jose Brice, Alexis Bruffaerts, Rose Camuzat, Agnès Cañada, Marta Cantoni, Valentina Caroppo, Paola Castelo-Branco, Miguel Colliot, Olivier Cope, Thomas Deramecourt, Vincent de Arriba, María Di Fede, Giuseppe Díez, Alina Duro, Diana Fenoglio, Chiara Ferrari, Camilla Ferreira, Catarina B. Fox, Nick Freedman, Morris Fumagalli, Giorgio Funkiewiez, Aurélie Gabilondo, Alazne Gasparotti, Roberto Gauthier, Serge Gazzina, Stefano Giaccone, Giorgio Gorostidi, Ana Greaves, Caroline Guerreiro, Rita Heller, Carolin Hoegen, Tobias Indakoetxea, Begoña Jelic, Vesna Karnath, Hans-Otto Keren, Ron Kuchcinski, Gregory Langheinrich, Tobias Lebouvier, Thibaud João Leitão, Maria Lladó, Albert Lombardi, Gemma Loosli, Sandra Maruta, Carolina Mead, Simon Meeter, Lieke Miltenberger, Gabriel van Minkelen, Rick Mitchell, Sara Moore, Katrina Nacmias, Benedetta Nelson, Annabel Nicholas, Jennifer Öijerstedt, Linn Olives, Jaume Ourselin, Sebastien Padovani, Alessandro Panman, Jessica Papma, Janne M. Pijnenburg, Yolande Polito, Cristina Premi, Enrico Prioni, Sara Prix, Catharina Rademakers, Rosa Redaelli, Veronica Rinaldi, Daisy Rittman, Tim Rogaeva, Ekaterina Rollin, Adeline Rosa-Neto, Pedro Rossi, Giacomina Rossor, Martin Santiago, Beatriz Saracino, Dario Sayah, Sabrina Scarpini, Elio Schönecker, Sonja Semler, Elisa Shafei, Rachelle Shoesmith, Christen Swift, Imogen Tábuas-Pereira, Miguel Tainta, Mikel Taipa, Ricardo Tang-Wai, David Thompson, Paul Thonberg, Hakan Timberlake, Carolyn Tiraboschi, Pietro Van Damme, Philip Vandenbulcke, Mathieu Veldsman, Michele Verdelho, Ana Villanua, Jorge Warren, Jason Wilke, Carlo Woollacott, Ione Wlasich, Elisabeth Zetterberg, Henrik Zulaica, Miren |
author_role |
author |
author2 |
Todd, Emily G. Peakman, Georgia Cash, David M. Convery, Rhian S. Russell, Lucy L. Thomas, David L. Eugenio Iglesias, Juan van Swieten, John C. Jiskoot, Lize C. Seelaar, Harro Borroni, Barbara Galimberti, Daniela Sanchez-Valle, Raquel Laforce, Robert Moreno, Fermin Synofzik, Matthis Graff, Caroline Masellis, Mario Carmela Tartaglia, Maria Rowe, James B. Vandenberghe, Rik Finger, Elizabeth Tagliavini, Fabrizio de Mendonça, Alexandre Santana, Isabel Butler, Chris R. Ducharme, Simon Gerhard, Alexander Danek, Adrian Levin, Johannes Otto, Markus Sorbi, Sandro Le Ber, Isabelle Pasquier, Florence Rohrer, Jonathan D. Afonso, Sónia Rosario Almeida, Maria Anderl-Straub, Sarah Andersson, Christin Antonell, Anna Archetti, Silvana Arighi, Andrea Balasa, Mircea Barandiaran, Myriam Bargalló, Nuria Bartha, Robart Bender, Benjamin Benussi, Alberto Bertoux, Maxime Bertrand, Anne Bessi, Valentina Black, Sandra Borrego-Ecija, Sergi Bras, Jose Brice, Alexis Bruffaerts, Rose Camuzat, Agnès Cañada, Marta Cantoni, Valentina Caroppo, Paola Castelo-Branco, Miguel Colliot, Olivier Cope, Thomas Deramecourt, Vincent de Arriba, María Di Fede, Giuseppe Díez, Alina Duro, Diana Fenoglio, Chiara Ferrari, Camilla Ferreira, Catarina B. Fox, Nick Freedman, Morris Fumagalli, Giorgio Funkiewiez, Aurélie Gabilondo, Alazne Gasparotti, Roberto Gauthier, Serge Gazzina, Stefano Giaccone, Giorgio Gorostidi, Ana Greaves, Caroline Guerreiro, Rita Heller, Carolin Hoegen, Tobias Indakoetxea, Begoña Jelic, Vesna Karnath, Hans-Otto Keren, Ron Kuchcinski, Gregory Langheinrich, Tobias Lebouvier, Thibaud João Leitão, Maria Lladó, Albert Lombardi, Gemma Loosli, Sandra Maruta, Carolina Mead, Simon Meeter, Lieke Miltenberger, Gabriel van Minkelen, Rick Mitchell, Sara Moore, Katrina Nacmias, Benedetta Nelson, Annabel Nicholas, Jennifer Öijerstedt, Linn Olives, Jaume Ourselin, Sebastien Padovani, Alessandro Panman, Jessica Papma, Janne M. Pijnenburg, Yolande Polito, Cristina Premi, Enrico Prioni, Sara Prix, Catharina Rademakers, Rosa Redaelli, Veronica Rinaldi, Daisy Rittman, Tim Rogaeva, Ekaterina Rollin, Adeline Rosa-Neto, Pedro Rossi, Giacomina Rossor, Martin Santiago, Beatriz Saracino, Dario Sayah, Sabrina Scarpini, Elio Schönecker, Sonja Semler, Elisa Shafei, Rachelle Shoesmith, Christen Swift, Imogen Tábuas-Pereira, Miguel Tainta, Mikel Taipa, Ricardo Tang-Wai, David Thompson, Paul Thonberg, Hakan Timberlake, Carolyn Tiraboschi, Pietro Van Damme, Philip Vandenbulcke, Mathieu Veldsman, Michele Verdelho, Ana Villanua, Jorge Warren, Jason Wilke, Carlo Woollacott, Ione Wlasich, Elisabeth Zetterberg, Henrik Zulaica, Miren |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Centro Hospitalar Universitário de Santo António |
dc.contributor.author.fl_str_mv |
Bocchetta, Martina Todd, Emily G. Peakman, Georgia Cash, David M. Convery, Rhian S. Russell, Lucy L. Thomas, David L. Eugenio Iglesias, Juan van Swieten, John C. Jiskoot, Lize C. Seelaar, Harro Borroni, Barbara Galimberti, Daniela Sanchez-Valle, Raquel Laforce, Robert Moreno, Fermin Synofzik, Matthis Graff, Caroline Masellis, Mario Carmela Tartaglia, Maria Rowe, James B. Vandenberghe, Rik Finger, Elizabeth Tagliavini, Fabrizio de Mendonça, Alexandre Santana, Isabel Butler, Chris R. Ducharme, Simon Gerhard, Alexander Danek, Adrian Levin, Johannes Otto, Markus Sorbi, Sandro Le Ber, Isabelle Pasquier, Florence Rohrer, Jonathan D. Afonso, Sónia Rosario Almeida, Maria Anderl-Straub, Sarah Andersson, Christin Antonell, Anna Archetti, Silvana Arighi, Andrea Balasa, Mircea Barandiaran, Myriam Bargalló, Nuria Bartha, Robart Bender, Benjamin Benussi, Alberto Bertoux, Maxime Bertrand, Anne Bessi, Valentina Black, Sandra Borrego-Ecija, Sergi Bras, Jose Brice, Alexis Bruffaerts, Rose Camuzat, Agnès Cañada, Marta Cantoni, Valentina Caroppo, Paola Castelo-Branco, Miguel Colliot, Olivier Cope, Thomas Deramecourt, Vincent de Arriba, María Di Fede, Giuseppe Díez, Alina Duro, Diana Fenoglio, Chiara Ferrari, Camilla Ferreira, Catarina B. Fox, Nick Freedman, Morris Fumagalli, Giorgio Funkiewiez, Aurélie Gabilondo, Alazne Gasparotti, Roberto Gauthier, Serge Gazzina, Stefano Giaccone, Giorgio Gorostidi, Ana Greaves, Caroline Guerreiro, Rita Heller, Carolin Hoegen, Tobias Indakoetxea, Begoña Jelic, Vesna Karnath, Hans-Otto Keren, Ron Kuchcinski, Gregory Langheinrich, Tobias Lebouvier, Thibaud João Leitão, Maria Lladó, Albert Lombardi, Gemma Loosli, Sandra Maruta, Carolina Mead, Simon Meeter, Lieke Miltenberger, Gabriel van Minkelen, Rick Mitchell, Sara Moore, Katrina Nacmias, Benedetta Nelson, Annabel Nicholas, Jennifer Öijerstedt, Linn Olives, Jaume Ourselin, Sebastien Padovani, Alessandro Panman, Jessica Papma, Janne M. Pijnenburg, Yolande Polito, Cristina Premi, Enrico Prioni, Sara Prix, Catharina Rademakers, Rosa Redaelli, Veronica Rinaldi, Daisy Rittman, Tim Rogaeva, Ekaterina Rollin, Adeline Rosa-Neto, Pedro Rossi, Giacomina Rossor, Martin Santiago, Beatriz Saracino, Dario Sayah, Sabrina Scarpini, Elio Schönecker, Sonja Semler, Elisa Shafei, Rachelle Shoesmith, Christen Swift, Imogen Tábuas-Pereira, Miguel Tainta, Mikel Taipa, Ricardo Tang-Wai, David Thompson, Paul Thonberg, Hakan Timberlake, Carolyn Tiraboschi, Pietro Van Damme, Philip Vandenbulcke, Mathieu Veldsman, Michele Verdelho, Ana Villanua, Jorge Warren, Jason Wilke, Carlo Woollacott, Ione Wlasich, Elisabeth Zetterberg, Henrik Zulaica, Miren |
dc.subject.por.fl_str_mv |
Brain volumetry Genetic frontotemporal dementia MRI imaging Presymptomatic stage |
topic |
Brain volumetry Genetic frontotemporal dementia MRI imaging Presymptomatic stage |
description |
Background: Studies have previously shown evidence for presymptomatic cortical atrophy in genetic FTD. Whilst initial investigations have also identified early deep grey matter volume loss, little is known about the extent of subcortical involvement, particularly within subregions, and how this differs between genetic groups. Methods: 480 mutation carriers from the Genetic FTD Initiative (GENFI) were included (198 GRN, 202 C9orf72, 80 MAPT), together with 298 non-carrier cognitively normal controls. Cortical and subcortical volumes of interest were generated using automated parcellation methods on volumetric 3 T T1-weighted MRI scans. Mutation carriers were divided into three disease stages based on their global CDR® plus NACC FTLD score: asymptomatic (0), possibly or mildly symptomatic (0.5) and fully symptomatic (1 or more). Results: In all three groups, subcortical involvement was seen at the CDR 0.5 stage prior to phenoconversion, whereas in the C9orf72 and MAPT mutation carriers there was also involvement at the CDR 0 stage. In the C9orf72 expansion carriers the earliest volume changes were in thalamic subnuclei (particularly pulvinar and lateral geniculate, 9-10%) cerebellum (lobules VIIa-Crus II and VIIIb, 2-3%), hippocampus (particularly presubiculum and CA1, 2-3%), amygdala (all subregions, 2-6%) and hypothalamus (superior tuberal region, 1%). In MAPT mutation carriers changes were seen at CDR 0 in the hippocampus (subiculum, presubiculum and tail, 3-4%) and amygdala (accessory basal and superficial nuclei, 2-4%). GRN mutation carriers showed subcortical differences at CDR 0.5 in the presubiculum of the hippocampus (8%). Conclusions: C9orf72 expansion carriers show the earliest and most widespread changes including the thalamus, basal ganglia and medial temporal lobe. By investigating individual subregions, changes can also be seen at CDR 0 in MAPT mutation carriers within the limbic system. Our results suggest that subcortical brain volumes may be used as markers of neurodegeneration even prior to the onset of prodromal symptoms. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 2021-01-01T00:00:00Z 2023-10-24T11:46:59Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.16/2849 |
url |
http://hdl.handle.net/10400.16/2849 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Bocchetta M, Todd EG, Peakman G, et al. Differential early subcortical involvement in genetic FTD within the GENFI cohort. Neuroimage Clin. 2021;30:102646. doi:10.1016/j.nicl.2021.102646 2213-1582 10.1016/j.nicl.2021.102646 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799133658001440768 |