Prognostic Value of Osteoprotegerin in Acute Heart Failure

Detalhes bibliográficos
Autor(a) principal: Friões, F
Data de Publicação: 2015
Outros Autores: Rocha, OL, Almeida, PB, Silva, N, Guimarães, JT, Omland, T, Azevedo, A, Bettencourt, P
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10216/114660
Resumo: Background: Osteoprotegerin (OPG) is promising as a predictor of adverse prognosis in patients with acute coronary syndromes and chronic heart failure. Its prognostic value in acute heart failure (AHF) is unknown. The aim of this study was to assess the prognostic value provided by serum OPG levels at discharge after an admission for AHF. Methods: In a prospective study, we enrolled 338 patients consecutively admitted with AHF to the internal medicine department of a tertiary care university hospital in Porto, Portugal between March 2009 and December 2010. OPG was measured using a commercial enzyme-linked immunosorbent assay and was both analyzed as a continuous variable and categorized by quartiles. Patients were followed for up to 6 months after discharge to ascertain the occurrence of all-cause death or hospital readmission resulting from AHF. Results: During follow-up, 119 patients died or were readmitted for AHF. A graded increase in the risk of the combined end point was observed across quartiles of OPG. At 6 months, the cumulative risk of the end point was 25% for the first quartile and 50% for the fourth quartile. The multivariable adjusted risk of death or hospitalization for AHF increased progressively across categories of OPG up to a statistically significant 2.44-fold increase in risk in the highest category (P for linear trend = 0.002, ie, by 5% per 10 pg/mL increase in OPG). Conclusions: Serum OPG was directly associated with a higher probability of death or readmission for AHF within 6 months, irrespective of other known prognostic markers. This was true both when the ejection fraction was preserved and when it was reduced.
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spelling Prognostic Value of Osteoprotegerin in Acute Heart FailureOsteoprotegerinAcute Heart FailureBackground: Osteoprotegerin (OPG) is promising as a predictor of adverse prognosis in patients with acute coronary syndromes and chronic heart failure. Its prognostic value in acute heart failure (AHF) is unknown. The aim of this study was to assess the prognostic value provided by serum OPG levels at discharge after an admission for AHF. Methods: In a prospective study, we enrolled 338 patients consecutively admitted with AHF to the internal medicine department of a tertiary care university hospital in Porto, Portugal between March 2009 and December 2010. OPG was measured using a commercial enzyme-linked immunosorbent assay and was both analyzed as a continuous variable and categorized by quartiles. Patients were followed for up to 6 months after discharge to ascertain the occurrence of all-cause death or hospital readmission resulting from AHF. Results: During follow-up, 119 patients died or were readmitted for AHF. A graded increase in the risk of the combined end point was observed across quartiles of OPG. At 6 months, the cumulative risk of the end point was 25% for the first quartile and 50% for the fourth quartile. The multivariable adjusted risk of death or hospitalization for AHF increased progressively across categories of OPG up to a statistically significant 2.44-fold increase in risk in the highest category (P for linear trend = 0.002, ie, by 5% per 10 pg/mL increase in OPG). Conclusions: Serum OPG was directly associated with a higher probability of death or readmission for AHF within 6 months, irrespective of other known prognostic markers. This was true both when the ejection fraction was preserved and when it was reduced.20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10216/114660eng0828-282X10.1016/j.cjca.2015.04.003Friões, FRocha, OLAlmeida, PBSilva, NGuimarães, JTOmland, TAzevedo, ABettencourt, Pinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T14:47:35Zoai:repositorio-aberto.up.pt:10216/114660Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:08:35.490261Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Prognostic Value of Osteoprotegerin in Acute Heart Failure
title Prognostic Value of Osteoprotegerin in Acute Heart Failure
spellingShingle Prognostic Value of Osteoprotegerin in Acute Heart Failure
Friões, F
Osteoprotegerin
Acute Heart Failure
title_short Prognostic Value of Osteoprotegerin in Acute Heart Failure
title_full Prognostic Value of Osteoprotegerin in Acute Heart Failure
title_fullStr Prognostic Value of Osteoprotegerin in Acute Heart Failure
title_full_unstemmed Prognostic Value of Osteoprotegerin in Acute Heart Failure
title_sort Prognostic Value of Osteoprotegerin in Acute Heart Failure
author Friões, F
author_facet Friões, F
Rocha, OL
Almeida, PB
Silva, N
Guimarães, JT
Omland, T
Azevedo, A
Bettencourt, P
author_role author
author2 Rocha, OL
Almeida, PB
Silva, N
Guimarães, JT
Omland, T
Azevedo, A
Bettencourt, P
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Friões, F
Rocha, OL
Almeida, PB
Silva, N
Guimarães, JT
Omland, T
Azevedo, A
Bettencourt, P
dc.subject.por.fl_str_mv Osteoprotegerin
Acute Heart Failure
topic Osteoprotegerin
Acute Heart Failure
description Background: Osteoprotegerin (OPG) is promising as a predictor of adverse prognosis in patients with acute coronary syndromes and chronic heart failure. Its prognostic value in acute heart failure (AHF) is unknown. The aim of this study was to assess the prognostic value provided by serum OPG levels at discharge after an admission for AHF. Methods: In a prospective study, we enrolled 338 patients consecutively admitted with AHF to the internal medicine department of a tertiary care university hospital in Porto, Portugal between March 2009 and December 2010. OPG was measured using a commercial enzyme-linked immunosorbent assay and was both analyzed as a continuous variable and categorized by quartiles. Patients were followed for up to 6 months after discharge to ascertain the occurrence of all-cause death or hospital readmission resulting from AHF. Results: During follow-up, 119 patients died or were readmitted for AHF. A graded increase in the risk of the combined end point was observed across quartiles of OPG. At 6 months, the cumulative risk of the end point was 25% for the first quartile and 50% for the fourth quartile. The multivariable adjusted risk of death or hospitalization for AHF increased progressively across categories of OPG up to a statistically significant 2.44-fold increase in risk in the highest category (P for linear trend = 0.002, ie, by 5% per 10 pg/mL increase in OPG). Conclusions: Serum OPG was directly associated with a higher probability of death or readmission for AHF within 6 months, irrespective of other known prognostic markers. This was true both when the ejection fraction was preserved and when it was reduced.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10216/114660
url http://hdl.handle.net/10216/114660
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dc.relation.none.fl_str_mv 0828-282X
10.1016/j.cjca.2015.04.003
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