Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapy

Detalhes bibliográficos
Autor(a) principal: Mendes, Cindy
Data de Publicação: 2019
Outros Autores: Lopes-Coelho, Filipa, Ramos, Cristiano, Martins, Filipa, Santos, Inês, Rodrigues, Armanda, Silva, Fernanda, André, Saudade, Serpa, Jacinta
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.1038/s41598-019-50531-3
Resumo: The authors thank to Shinozuka Tsuyoshi from Daiichi Sankyo, Japan, for the supply of arylpiperazine 5k (DS22420314). The research was funded by IPOLFG, EPE (FAI 2017) and by iNOVA4Health - UID/Multi/04462/a program fnancially supported by Fundação para a Ciência e Tecnologia/Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement and by Fundação para a Ciência e Tecnologia (personal fellowship: PD/BD/128337/2017).
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spelling Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapyGeneralSDG 3 - Good Health and Well-beingThe authors thank to Shinozuka Tsuyoshi from Daiichi Sankyo, Japan, for the supply of arylpiperazine 5k (DS22420314). The research was funded by IPOLFG, EPE (FAI 2017) and by iNOVA4Health - UID/Multi/04462/a program fnancially supported by Fundação para a Ciência e Tecnologia/Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement and by Fundação para a Ciência e Tecnologia (personal fellowship: PD/BD/128337/2017).The biochemical demands associated with tumor proliferation prompt neoplastic cells to augment the import of nutrients to sustain their survival and fuel cell growth, with a consequent metabolic remodeling. Fatty acids (FA) are crucial in this process, since they have a dual role as energetic coins and building blocks. Recently, our team has shown that FATP1 has a pivotal role in FA transfer between breast cancer cells (BCCs) and non-cancerous cells in the microenvironment. We aimed to investigate the role of FATP1 in BCCs and also to explore if FATP1 inhibition is a promising therapeutic strategy. In patients' data, we showed a higher expression of FATP1/SLC27A1 in TNBC, which correlated with a significant decreased overall survival (OS). In vitro, we verified that FA and estradiol stimulated FATP1/SLC27A1 expression in BCCs. Additionally, experiments with estradiol and PHTPP (ER-β antagonist) showed that estrogen receptor-β (ER-β) regulates FATP1/SLC27A1 expression, the uptake of FA and cell viability, in four BCC lines. Furthermore, the inhibition of FATP1 with arylpiperazine 5k (DS22420314) interfered with the uptake of FA and cell viability. Our study, unraveled FATP1 as a putative therapeutic target in breast cancer (BC).Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNMendes, CindyLopes-Coelho, FilipaRamos, CristianoMartins, FilipaSantos, InêsRodrigues, ArmandaSilva, FernandaAndré, SaudadeSerpa, Jacinta2019-10-11T23:10:29Z2019-10-012019-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1application/pdfhttps://doi.org/10.1038/s41598-019-50531-3eng2045-2322PURE: 14980157http://www.scopus.com/inward/record.url?scp=85072847618&partnerID=8YFLogxKhttps://doi.org/10.1038/s41598-019-50531-3info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:37:33Zoai:run.unl.pt:10362/84041Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:36:25.679818Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapy
title Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapy
spellingShingle Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapy
Mendes, Cindy
General
SDG 3 - Good Health and Well-being
title_short Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapy
title_full Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapy
title_fullStr Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapy
title_full_unstemmed Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapy
title_sort Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapy
author Mendes, Cindy
author_facet Mendes, Cindy
Lopes-Coelho, Filipa
Ramos, Cristiano
Martins, Filipa
Santos, Inês
Rodrigues, Armanda
Silva, Fernanda
André, Saudade
Serpa, Jacinta
author_role author
author2 Lopes-Coelho, Filipa
Ramos, Cristiano
Martins, Filipa
Santos, Inês
Rodrigues, Armanda
Silva, Fernanda
André, Saudade
Serpa, Jacinta
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Centro de Estudos de Doenças Crónicas (CEDOC)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Mendes, Cindy
Lopes-Coelho, Filipa
Ramos, Cristiano
Martins, Filipa
Santos, Inês
Rodrigues, Armanda
Silva, Fernanda
André, Saudade
Serpa, Jacinta
dc.subject.por.fl_str_mv General
SDG 3 - Good Health and Well-being
topic General
SDG 3 - Good Health and Well-being
description The authors thank to Shinozuka Tsuyoshi from Daiichi Sankyo, Japan, for the supply of arylpiperazine 5k (DS22420314). The research was funded by IPOLFG, EPE (FAI 2017) and by iNOVA4Health - UID/Multi/04462/a program fnancially supported by Fundação para a Ciência e Tecnologia/Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement and by Fundação para a Ciência e Tecnologia (personal fellowship: PD/BD/128337/2017).
publishDate 2019
dc.date.none.fl_str_mv 2019-10-11T23:10:29Z
2019-10-01
2019-10-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.1038/s41598-019-50531-3
url https://doi.org/10.1038/s41598-019-50531-3
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2045-2322
PURE: 14980157
http://www.scopus.com/inward/record.url?scp=85072847618&partnerID=8YFLogxK
https://doi.org/10.1038/s41598-019-50531-3
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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