Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/152631 |
Resumo: | Knowledge about human papillomaviruses (HPV) types involved in anal cancers in some world regions is scanty. Here, we describe the HPV DNA prevalence and type distribution in a series of invasive anal cancers and anal intraepithelial neoplasias (AIN) grades 2/3 from 24 countries. We analyzed 43 AIN 2/3 cases and 496 anal cancers diagnosed from 1986 to 2011. After histopathological evaluation of formalin-fixed paraffin-embedded samples, HPV DNA detection and genotyping was performed using SPF-10/DEIA/LiPA25 system (version 1). A subset of 116 cancers was further tested for p16INK4a expression, a cellular surrogate marker for HPV-associated transformation. Prevalence ratios were estimated using multivariate Poisson regression with robust variance in the anal cancer data set. HPV DNA was detected in 88.3% of anal cancers (95% confidence interval [CI]: 85.1-91.0%) and in 95.3% of AIN 2/3 (95% CI: 84.2-99.4%). Among cancers, the highest prevalence was observed in warty-basaloid subtype of squamous cell carcinomas, in younger patients and in North American geographical region. There were no statistically significant differences in prevalence by gender. HPV16 was the most frequent HPV type detected in both cancers (80.7%) and AIN 2/3 lesions (75.4%). HPV18 was the second most common type in invasive cancers (3.6%). p16INK4a overexpression was found in 95% of HPV DNA-positive anal cancers. In view of the results of HPV DNA and high proportion of p16INK4a overexpression, infection by HPV is most likely to be a necessary cause for anal cancers in both men and women. The large contribution of HPV16 reinforces the potential impact of HPV vaccines in the prevention of these lesions. What's new? Human papillomavirus (HPV) is linked to anal cancer through high HPV DNA-detection rates. Here, in one of the largest international studies to date, HPV DNA was detected in more than 88% of anal cancers and more than 95% of anal intraepithelial neoplasias grades 2/3. HPV16 was the most frequently detected virus type, followed by HPV18. Overexpression of p16INK4a, a surrogate marker for HPV-associated transformation, was found in 95% of HPV-positive anal cancers. The data implicate HPV as a causative factor in anal cancer. |
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Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwideanal cancerhuman papillomavirusvaccineOncologyCancer ResearchSDG 3 - Good Health and Well-beingKnowledge about human papillomaviruses (HPV) types involved in anal cancers in some world regions is scanty. Here, we describe the HPV DNA prevalence and type distribution in a series of invasive anal cancers and anal intraepithelial neoplasias (AIN) grades 2/3 from 24 countries. We analyzed 43 AIN 2/3 cases and 496 anal cancers diagnosed from 1986 to 2011. After histopathological evaluation of formalin-fixed paraffin-embedded samples, HPV DNA detection and genotyping was performed using SPF-10/DEIA/LiPA25 system (version 1). A subset of 116 cancers was further tested for p16INK4a expression, a cellular surrogate marker for HPV-associated transformation. Prevalence ratios were estimated using multivariate Poisson regression with robust variance in the anal cancer data set. HPV DNA was detected in 88.3% of anal cancers (95% confidence interval [CI]: 85.1-91.0%) and in 95.3% of AIN 2/3 (95% CI: 84.2-99.4%). Among cancers, the highest prevalence was observed in warty-basaloid subtype of squamous cell carcinomas, in younger patients and in North American geographical region. There were no statistically significant differences in prevalence by gender. HPV16 was the most frequent HPV type detected in both cancers (80.7%) and AIN 2/3 lesions (75.4%). HPV18 was the second most common type in invasive cancers (3.6%). p16INK4a overexpression was found in 95% of HPV DNA-positive anal cancers. In view of the results of HPV DNA and high proportion of p16INK4a overexpression, infection by HPV is most likely to be a necessary cause for anal cancers in both men and women. The large contribution of HPV16 reinforces the potential impact of HPV vaccines in the prevention of these lesions. What's new? Human papillomavirus (HPV) is linked to anal cancer through high HPV DNA-detection rates. Here, in one of the largest international studies to date, HPV DNA was detected in more than 88% of anal cancers and more than 95% of anal intraepithelial neoplasias grades 2/3. HPV16 was the most frequently detected virus type, followed by HPV18. Overexpression of p16INK4a, a surrogate marker for HPV-associated transformation, was found in 95% of HPV-positive anal cancers. The data implicate HPV as a causative factor in anal cancer.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNAlemany, LaiaSaunier, MaëlleAlvarado-Cabrero, IsabelQuirõs, BeatrizSalmeron, JorgeShin, Hai RimPirog, Edyta C.Guimerà, NúriaHernandez-Suarez, GustavoFelix, AnaClavero, OmarLloveras, BelenKasamatsu, ElenaGoodman, Marc T.Hernandez, Brenda Y.Laco, JanTinoco, LeopoldoGeraets, Daan T.Lynch, Charles F.Mandys, VaclavPoljak, MarioJach, RobertVerge, JosepClavel, ChristineNdiaye, CathyKlaustermeier, JoellenCubilla, AntonioCastellsagué, XavierBravo, Ignacio G.Pawlita, MichaelQuint, William G.Muñoz, NubiaBosch, Francesc X.De Sanjosé, Silvia2023-05-11T22:08:14Z2015-01-012015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10application/pdfhttp://hdl.handle.net/10362/152631eng0020-7136PURE: 4338955https://doi.org/10.1002/ijc.28963info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:34:56Zoai:run.unl.pt:10362/152631Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:54:59.894103Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide |
title |
Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide |
spellingShingle |
Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide Alemany, Laia anal cancer human papillomavirus vaccine Oncology Cancer Research SDG 3 - Good Health and Well-being |
title_short |
Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide |
title_full |
Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide |
title_fullStr |
Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide |
title_full_unstemmed |
Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide |
title_sort |
Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide |
author |
Alemany, Laia |
author_facet |
Alemany, Laia Saunier, Maëlle Alvarado-Cabrero, Isabel Quirõs, Beatriz Salmeron, Jorge Shin, Hai Rim Pirog, Edyta C. Guimerà, Núria Hernandez-Suarez, Gustavo Felix, Ana Clavero, Omar Lloveras, Belen Kasamatsu, Elena Goodman, Marc T. Hernandez, Brenda Y. Laco, Jan Tinoco, Leopoldo Geraets, Daan T. Lynch, Charles F. Mandys, Vaclav Poljak, Mario Jach, Robert Verge, Josep Clavel, Christine Ndiaye, Cathy Klaustermeier, Joellen Cubilla, Antonio Castellsagué, Xavier Bravo, Ignacio G. Pawlita, Michael Quint, William G. Muñoz, Nubia Bosch, Francesc X. De Sanjosé, Silvia |
author_role |
author |
author2 |
Saunier, Maëlle Alvarado-Cabrero, Isabel Quirõs, Beatriz Salmeron, Jorge Shin, Hai Rim Pirog, Edyta C. Guimerà, Núria Hernandez-Suarez, Gustavo Felix, Ana Clavero, Omar Lloveras, Belen Kasamatsu, Elena Goodman, Marc T. Hernandez, Brenda Y. Laco, Jan Tinoco, Leopoldo Geraets, Daan T. Lynch, Charles F. Mandys, Vaclav Poljak, Mario Jach, Robert Verge, Josep Clavel, Christine Ndiaye, Cathy Klaustermeier, Joellen Cubilla, Antonio Castellsagué, Xavier Bravo, Ignacio G. Pawlita, Michael Quint, William G. Muñoz, Nubia Bosch, Francesc X. De Sanjosé, Silvia |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Centro de Estudos de Doenças Crónicas (CEDOC) RUN |
dc.contributor.author.fl_str_mv |
Alemany, Laia Saunier, Maëlle Alvarado-Cabrero, Isabel Quirõs, Beatriz Salmeron, Jorge Shin, Hai Rim Pirog, Edyta C. Guimerà, Núria Hernandez-Suarez, Gustavo Felix, Ana Clavero, Omar Lloveras, Belen Kasamatsu, Elena Goodman, Marc T. Hernandez, Brenda Y. Laco, Jan Tinoco, Leopoldo Geraets, Daan T. Lynch, Charles F. Mandys, Vaclav Poljak, Mario Jach, Robert Verge, Josep Clavel, Christine Ndiaye, Cathy Klaustermeier, Joellen Cubilla, Antonio Castellsagué, Xavier Bravo, Ignacio G. Pawlita, Michael Quint, William G. Muñoz, Nubia Bosch, Francesc X. De Sanjosé, Silvia |
dc.subject.por.fl_str_mv |
anal cancer human papillomavirus vaccine Oncology Cancer Research SDG 3 - Good Health and Well-being |
topic |
anal cancer human papillomavirus vaccine Oncology Cancer Research SDG 3 - Good Health and Well-being |
description |
Knowledge about human papillomaviruses (HPV) types involved in anal cancers in some world regions is scanty. Here, we describe the HPV DNA prevalence and type distribution in a series of invasive anal cancers and anal intraepithelial neoplasias (AIN) grades 2/3 from 24 countries. We analyzed 43 AIN 2/3 cases and 496 anal cancers diagnosed from 1986 to 2011. After histopathological evaluation of formalin-fixed paraffin-embedded samples, HPV DNA detection and genotyping was performed using SPF-10/DEIA/LiPA25 system (version 1). A subset of 116 cancers was further tested for p16INK4a expression, a cellular surrogate marker for HPV-associated transformation. Prevalence ratios were estimated using multivariate Poisson regression with robust variance in the anal cancer data set. HPV DNA was detected in 88.3% of anal cancers (95% confidence interval [CI]: 85.1-91.0%) and in 95.3% of AIN 2/3 (95% CI: 84.2-99.4%). Among cancers, the highest prevalence was observed in warty-basaloid subtype of squamous cell carcinomas, in younger patients and in North American geographical region. There were no statistically significant differences in prevalence by gender. HPV16 was the most frequent HPV type detected in both cancers (80.7%) and AIN 2/3 lesions (75.4%). HPV18 was the second most common type in invasive cancers (3.6%). p16INK4a overexpression was found in 95% of HPV DNA-positive anal cancers. In view of the results of HPV DNA and high proportion of p16INK4a overexpression, infection by HPV is most likely to be a necessary cause for anal cancers in both men and women. The large contribution of HPV16 reinforces the potential impact of HPV vaccines in the prevention of these lesions. What's new? Human papillomavirus (HPV) is linked to anal cancer through high HPV DNA-detection rates. Here, in one of the largest international studies to date, HPV DNA was detected in more than 88% of anal cancers and more than 95% of anal intraepithelial neoplasias grades 2/3. HPV16 was the most frequently detected virus type, followed by HPV18. Overexpression of p16INK4a, a surrogate marker for HPV-associated transformation, was found in 95% of HPV-positive anal cancers. The data implicate HPV as a causative factor in anal cancer. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-01-01 2015-01-01T00:00:00Z 2023-05-11T22:08:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/152631 |
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http://hdl.handle.net/10362/152631 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0020-7136 PURE: 4338955 https://doi.org/10.1002/ijc.28963 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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10 application/pdf |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799138137974243328 |