Bacterial vaginosis biofilms: challenges to current therapies and emerging solutions
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/40150 |
Resumo: | Bacterial vaginosis (BV) is the most common genital tract infection in women during their reproductive years and it has been associated with serious health complications, such as preterm delivery and acquisition or transmission of several sexually transmitted agents. BV is characterized by a reduction of beneficial lactobacilli and a significant increase in number of anaerobic bacteria, including Gardnerella vaginalis, Atopobium vaginae, Mobiluncus spp., Bacteroides spp. and Prevotella spp.. Being polymicrobial in nature, BV etiology remains unclear. However, it is certain that BV involves the presence of a thick vaginal multi-species biofilm, where G. vaginalis is the predominant species. Similar to what happens in many other biofilm-related infections, standard antibiotics, like metronidazole, are unable to fully eradicate the vaginal biofilm, which can explain the high recurrence rates of BV. Furthermore, antibiotic therapy can also cause a negative impact on the healthy vaginal microflora. These issues sparked the interest in developing alternative therapeutic strategies. This review provides a quick synopsis of the currently approved and available antibiotics for BV treatment while presenting an overview of novel strategies that are being explored for the treatment of this disorder, with special focus on natural compounds that are able to overcome biofilm-associated antibiotic resistance. |
id |
RCAP_2763f36952cf13c45890faca609f58a4 |
---|---|
oai_identifier_str |
oai:repositorium.sdum.uminho.pt:1822/40150 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Bacterial vaginosis biofilms: challenges to current therapies and emerging solutionsBacterial vaginosisBiofilmsGardnerella vaginalisAntibioticsEmerging therapiesScience & TechnologyBacterial vaginosis (BV) is the most common genital tract infection in women during their reproductive years and it has been associated with serious health complications, such as preterm delivery and acquisition or transmission of several sexually transmitted agents. BV is characterized by a reduction of beneficial lactobacilli and a significant increase in number of anaerobic bacteria, including Gardnerella vaginalis, Atopobium vaginae, Mobiluncus spp., Bacteroides spp. and Prevotella spp.. Being polymicrobial in nature, BV etiology remains unclear. However, it is certain that BV involves the presence of a thick vaginal multi-species biofilm, where G. vaginalis is the predominant species. Similar to what happens in many other biofilm-related infections, standard antibiotics, like metronidazole, are unable to fully eradicate the vaginal biofilm, which can explain the high recurrence rates of BV. Furthermore, antibiotic therapy can also cause a negative impact on the healthy vaginal microflora. These issues sparked the interest in developing alternative therapeutic strategies. This review provides a quick synopsis of the currently approved and available antibiotics for BV treatment while presenting an overview of novel strategies that are being explored for the treatment of this disorder, with special focus on natural compounds that are able to overcome biofilm-associated antibiotic resistance.Research on BV biofilms in NC laboratory is supported by funding from the Fundação para a Ciência e a Tecnologia (FCT) strategic project of unit UID/BIO/04469/2013. DM and JC acknowledge the FCT fellowships SFRH/BD/87569/2012 and SFRH/BD/93963/2013 respectively. NC is an Investigador FCT.Frontiers MediaUniversidade do MinhoMachado, D.Castro, J.Oliveira, Ana Palmeira deOliveira, José Martinez deCerca, Nuno2016-01-202016-01-20T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/40150engMachado, D.; Castro, J.; Palmeira-de-Oliveira, Ana; Martinez-de-Oliveira, José; Cerca N, Bacterial vaginosis biofilms: challenges to current therapies and emerging solutions. Frontiers in Microbiology, 6(1528), 1-13, 20161664-302X1664-302X10.3389/fmicb.2015.01528http://journal.frontiersin.org/journal/microbiologyinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:42:08Zoai:repositorium.sdum.uminho.pt:1822/40150Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:39:18.895477Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Bacterial vaginosis biofilms: challenges to current therapies and emerging solutions |
title |
Bacterial vaginosis biofilms: challenges to current therapies and emerging solutions |
spellingShingle |
Bacterial vaginosis biofilms: challenges to current therapies and emerging solutions Machado, D. Bacterial vaginosis Biofilms Gardnerella vaginalis Antibiotics Emerging therapies Science & Technology |
title_short |
Bacterial vaginosis biofilms: challenges to current therapies and emerging solutions |
title_full |
Bacterial vaginosis biofilms: challenges to current therapies and emerging solutions |
title_fullStr |
Bacterial vaginosis biofilms: challenges to current therapies and emerging solutions |
title_full_unstemmed |
Bacterial vaginosis biofilms: challenges to current therapies and emerging solutions |
title_sort |
Bacterial vaginosis biofilms: challenges to current therapies and emerging solutions |
author |
Machado, D. |
author_facet |
Machado, D. Castro, J. Oliveira, Ana Palmeira de Oliveira, José Martinez de Cerca, Nuno |
author_role |
author |
author2 |
Castro, J. Oliveira, Ana Palmeira de Oliveira, José Martinez de Cerca, Nuno |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Machado, D. Castro, J. Oliveira, Ana Palmeira de Oliveira, José Martinez de Cerca, Nuno |
dc.subject.por.fl_str_mv |
Bacterial vaginosis Biofilms Gardnerella vaginalis Antibiotics Emerging therapies Science & Technology |
topic |
Bacterial vaginosis Biofilms Gardnerella vaginalis Antibiotics Emerging therapies Science & Technology |
description |
Bacterial vaginosis (BV) is the most common genital tract infection in women during their reproductive years and it has been associated with serious health complications, such as preterm delivery and acquisition or transmission of several sexually transmitted agents. BV is characterized by a reduction of beneficial lactobacilli and a significant increase in number of anaerobic bacteria, including Gardnerella vaginalis, Atopobium vaginae, Mobiluncus spp., Bacteroides spp. and Prevotella spp.. Being polymicrobial in nature, BV etiology remains unclear. However, it is certain that BV involves the presence of a thick vaginal multi-species biofilm, where G. vaginalis is the predominant species. Similar to what happens in many other biofilm-related infections, standard antibiotics, like metronidazole, are unable to fully eradicate the vaginal biofilm, which can explain the high recurrence rates of BV. Furthermore, antibiotic therapy can also cause a negative impact on the healthy vaginal microflora. These issues sparked the interest in developing alternative therapeutic strategies. This review provides a quick synopsis of the currently approved and available antibiotics for BV treatment while presenting an overview of novel strategies that are being explored for the treatment of this disorder, with special focus on natural compounds that are able to overcome biofilm-associated antibiotic resistance. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-20 2016-01-20T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/40150 |
url |
http://hdl.handle.net/1822/40150 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Machado, D.; Castro, J.; Palmeira-de-Oliveira, Ana; Martinez-de-Oliveira, José; Cerca N, Bacterial vaginosis biofilms: challenges to current therapies and emerging solutions. Frontiers in Microbiology, 6(1528), 1-13, 2016 1664-302X 1664-302X 10.3389/fmicb.2015.01528 http://journal.frontiersin.org/journal/microbiology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799132933395578880 |