Bottom-up microwave-assisted seed-mediated synthesis of gold nanoparticles onto nanocellulose to boost stability and high performance for SERS applications
Main Author: | |
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Publication Date: | 2021 |
Other Authors: | , , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Download full: | http://hdl.handle.net/1822/72619 |
Summary: | The development of accurate, reliable, inexpensive and fully recyclable analytical platforms is of utmost relevance to several fields from medical diagnosis to environmental screening. Surface-enhanced Raman spectroscopy (SERS) is a compelling detection method with high specificity and sensitivity. In this work, a microwave-assisted synthesis method was used for fast and uniform in situ growth of gold nanoparticles (AuNPs) onto nanocellulose (NC) membranes, through a seedmediated process. The as-prepared membranes were fully optimized and its application as SERS platforms was demonstrated. A direct comparison with other cellulose-based substrates showed the superior characteristics of NC such as high mechanical strength, high surface area and lower porous content. An Enhancement Factor (EF) up to 106 was obtained using rhodamine 6G (R6G) 10-6 M as probe molecule and a remarkable shelf life of at least 7 months was achieved, with no special storage required. Preliminary results on the detection of label-free spike protein present in SARSCoV-2 virus are shown, through direct measurements on the optimized SERS membrane. We believe that this work evidences the effectiveness of in situ seed-mediated microwave-assisted synthesis as a fabrication method, the high stability of AuNPs and the superior characteristics of NC substrates to be used as SERS platforms. |
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Bottom-up microwave-assisted seed-mediated synthesis of gold nanoparticles onto nanocellulose to boost stability and high performance for SERS applicationsMicrowave-assisted synthesisGold nanoparticlesNanocelluloseSERS: Point-of-care biosensorsCOVID-19SERSPoint-of-care biosensorsScience & TechnologyThe development of accurate, reliable, inexpensive and fully recyclable analytical platforms is of utmost relevance to several fields from medical diagnosis to environmental screening. Surface-enhanced Raman spectroscopy (SERS) is a compelling detection method with high specificity and sensitivity. In this work, a microwave-assisted synthesis method was used for fast and uniform in situ growth of gold nanoparticles (AuNPs) onto nanocellulose (NC) membranes, through a seedmediated process. The as-prepared membranes were fully optimized and its application as SERS platforms was demonstrated. A direct comparison with other cellulose-based substrates showed the superior characteristics of NC such as high mechanical strength, high surface area and lower porous content. An Enhancement Factor (EF) up to 106 was obtained using rhodamine 6G (R6G) 10-6 M as probe molecule and a remarkable shelf life of at least 7 months was achieved, with no special storage required. Preliminary results on the detection of label-free spike protein present in SARSCoV-2 virus are shown, through direct measurements on the optimized SERS membrane. We believe that this work evidences the effectiveness of in situ seed-mediated microwave-assisted synthesis as a fabrication method, the high stability of AuNPs and the superior characteristics of NC substrates to be used as SERS platforms.This work is funded by National Funds through FCT I.P., under the scope of the project UIDB/50025/2020-2023. The authors acknowledge the ERC AdG project DIGISMART ref. 787410 and EC project SYNERGY H2020-WIDESPREAD-2020-5, CSA, proposal n° 952169. Also, the authors thank funding co-financed by the Operational Programme for Competitiveness and Internationalisation (COMPETE 2020) and Lisbon Regional Operational Programme (Lisboa 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) under the projects ECO2COVID ref. 68174 and TecniCOV ref. 69745. A. C. Marques acknowledges funding from FCT I.P., through the PhD Grant SFRH/BD/115173/2016. The authors acknowledge Professor Pedro Costa from KAUST for the TEM imaging.info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoMarques, A. C.Pinheiro, T.Morais, M.Martins, C.Andrade, A. F.Martins, R.Sales, M. G. F.Fortunato, E.2021-05-092021-05-09T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/72619engMarques, A. C.; Pinheiro, T.; Morais, M.; Martins, C.; Andrade, A. F.; Martins, R.; Sales, M. G. F.; Fortunato, E., Bottom-up microwave-assisted seed-mediated synthesis of gold nanoparticles onto nanocellulose to boost stability and high performance for SERS applications. Applied Surface Science, No. 150060, 20210169-433210.1016/j.apsusc.2021.150060150060https://www.sciencedirect.com/science/article/abs/pii/S0169433221011363info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:14:57Zoai:repositorium.sdum.uminho.pt:1822/72619Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:07:19.225357Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Bottom-up microwave-assisted seed-mediated synthesis of gold nanoparticles onto nanocellulose to boost stability and high performance for SERS applications |
title |
Bottom-up microwave-assisted seed-mediated synthesis of gold nanoparticles onto nanocellulose to boost stability and high performance for SERS applications |
spellingShingle |
Bottom-up microwave-assisted seed-mediated synthesis of gold nanoparticles onto nanocellulose to boost stability and high performance for SERS applications Marques, A. C. Microwave-assisted synthesis Gold nanoparticles Nanocellulose SERS: Point-of-care biosensors COVID-19 SERS Point-of-care biosensors Science & Technology |
title_short |
Bottom-up microwave-assisted seed-mediated synthesis of gold nanoparticles onto nanocellulose to boost stability and high performance for SERS applications |
title_full |
Bottom-up microwave-assisted seed-mediated synthesis of gold nanoparticles onto nanocellulose to boost stability and high performance for SERS applications |
title_fullStr |
Bottom-up microwave-assisted seed-mediated synthesis of gold nanoparticles onto nanocellulose to boost stability and high performance for SERS applications |
title_full_unstemmed |
Bottom-up microwave-assisted seed-mediated synthesis of gold nanoparticles onto nanocellulose to boost stability and high performance for SERS applications |
title_sort |
Bottom-up microwave-assisted seed-mediated synthesis of gold nanoparticles onto nanocellulose to boost stability and high performance for SERS applications |
author |
Marques, A. C. |
author_facet |
Marques, A. C. Pinheiro, T. Morais, M. Martins, C. Andrade, A. F. Martins, R. Sales, M. G. F. Fortunato, E. |
author_role |
author |
author2 |
Pinheiro, T. Morais, M. Martins, C. Andrade, A. F. Martins, R. Sales, M. G. F. Fortunato, E. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Marques, A. C. Pinheiro, T. Morais, M. Martins, C. Andrade, A. F. Martins, R. Sales, M. G. F. Fortunato, E. |
dc.subject.por.fl_str_mv |
Microwave-assisted synthesis Gold nanoparticles Nanocellulose SERS: Point-of-care biosensors COVID-19 SERS Point-of-care biosensors Science & Technology |
topic |
Microwave-assisted synthesis Gold nanoparticles Nanocellulose SERS: Point-of-care biosensors COVID-19 SERS Point-of-care biosensors Science & Technology |
description |
The development of accurate, reliable, inexpensive and fully recyclable analytical platforms is of utmost relevance to several fields from medical diagnosis to environmental screening. Surface-enhanced Raman spectroscopy (SERS) is a compelling detection method with high specificity and sensitivity. In this work, a microwave-assisted synthesis method was used for fast and uniform in situ growth of gold nanoparticles (AuNPs) onto nanocellulose (NC) membranes, through a seedmediated process. The as-prepared membranes were fully optimized and its application as SERS platforms was demonstrated. A direct comparison with other cellulose-based substrates showed the superior characteristics of NC such as high mechanical strength, high surface area and lower porous content. An Enhancement Factor (EF) up to 106 was obtained using rhodamine 6G (R6G) 10-6 M as probe molecule and a remarkable shelf life of at least 7 months was achieved, with no special storage required. Preliminary results on the detection of label-free spike protein present in SARSCoV-2 virus are shown, through direct measurements on the optimized SERS membrane. We believe that this work evidences the effectiveness of in situ seed-mediated microwave-assisted synthesis as a fabrication method, the high stability of AuNPs and the superior characteristics of NC substrates to be used as SERS platforms. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-05-09 2021-05-09T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/72619 |
url |
http://hdl.handle.net/1822/72619 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Marques, A. C.; Pinheiro, T.; Morais, M.; Martins, C.; Andrade, A. F.; Martins, R.; Sales, M. G. F.; Fortunato, E., Bottom-up microwave-assisted seed-mediated synthesis of gold nanoparticles onto nanocellulose to boost stability and high performance for SERS applications. Applied Surface Science, No. 150060, 2021 0169-4332 10.1016/j.apsusc.2021.150060 150060 https://www.sciencedirect.com/science/article/abs/pii/S0169433221011363 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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