Swine enteric colibacillosis: Current treatment avenues and future directions

Detalhes bibliográficos
Autor(a) principal: Castro, Joana
Data de Publicação: 2022
Outros Autores: Barros, Maria Margarida, Araújo, Daniela, Campos, Ana Maria, Oliveira, Ricardo, Silva, Sónia Carina, Almeida, Carina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/82632
Resumo: The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fvets.2022.981207/full#supplementary-material
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spelling Swine enteric colibacillosis: Current treatment avenues and future directionsenteric colibacillosispost-weaning diarrheagutmicrobiomeantibiotic therapyzinc oxidenovel antimicrobial approachesThe Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fvets.2022.981207/full#supplementary-materialEnteric colibacillosis is a common disease in nursing and weanling pigs. It is caused by the colonization of the small intestine by enterotoxigenic strains of Escherichia coli (ETEC) that make use of specific fimbria or pili to adhere to the absorptive epithelial cells of the jejunum and ileum. Once attached, and when both the immunological systems and the gut microbiota are poorly developed, ETEC produce one or more enterotoxins that can have local and, further on, systemic effects. These enterotoxins cause fluid and electrolytes to be secreted into the intestinal lumen of animals, which results in diarrhea, dehydration, and acidosis. From the diversity of control strategies, antibiotics and zinc oxide are the ones that have contributed more significantly to mitigating post-weaning diarrhea (PWD) economic losses. However, concerns about antibiotic resistance determined the restriction on the use of critically important antimicrobials in food-producing animals and the prohibition of their use as growth promoters. As such, it is important now to begin the transition from these preventive/control measures to other, more sustainable, approaches. This review provides a quick synopsis of the currently approved and available therapies for PWD treatment while presenting an overview of novel antimicrobial strategies that are being explored for the control and treatment of this infection, including, prebiotics, probiotics, synbiotics, organic acids, bacteriophages, spray-dried plasma, antibodies, phytogenic substances, antisense oligonucleotides, and aptamers.Research in swine colibacillosis in CA Laboratory was supported by funding from the Fundação para a Ciência e a Tecnologia (FCT) Strategic Project Unit PTDC/CVT-CVT/4620/2021. It was also partially funded by LA/P/0045/2020 (ALiCE), UIDB/00511/2020 and UIDP/00511/2020 (LEPABE), funded by national funds through FCT/MCTES (PIDDAC), by FCT under the scope of the strategic funding of UIDB/04469/2020 unit (CEB), and by LABBELS-Associate Laboratory in Biotechnology, Bioengineering, and Microelectromechnaical Systems, LA/P/0029/2020.info:eu-repo/semantics/publishedVersionFrontiers Media S.A.Universidade do MinhoCastro, JoanaBarros, Maria MargaridaAraújo, DanielaCampos, Ana MariaOliveira, RicardoSilva, Sónia CarinaAlmeida, Carina2022-10-282022-10-28T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/82632engCastro, J., Barros, M. M., Araújo, D., Campos, A. M., Oliveira, R., Silva, S., & Almeida, C. (2022, October 28). Swine enteric colibacillosis: Current treatment avenues and future directions. Frontiers in Veterinary Science. Frontiers Media SA. http://doi.org/10.3389/fvets.2022.9812072297-176910.3389/fvets.2022.981207981207https://www.frontiersin.org/articles/10.3389/fvets.2022.981207/fullinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-30T01:24:17Zoai:repositorium.sdum.uminho.pt:1822/82632Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:04:24.176897Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Swine enteric colibacillosis: Current treatment avenues and future directions
title Swine enteric colibacillosis: Current treatment avenues and future directions
spellingShingle Swine enteric colibacillosis: Current treatment avenues and future directions
Castro, Joana
enteric colibacillosis
post-weaning diarrhea
gutmicrobiome
antibiotic therapy
zinc oxide
novel antimicrobial approaches
title_short Swine enteric colibacillosis: Current treatment avenues and future directions
title_full Swine enteric colibacillosis: Current treatment avenues and future directions
title_fullStr Swine enteric colibacillosis: Current treatment avenues and future directions
title_full_unstemmed Swine enteric colibacillosis: Current treatment avenues and future directions
title_sort Swine enteric colibacillosis: Current treatment avenues and future directions
author Castro, Joana
author_facet Castro, Joana
Barros, Maria Margarida
Araújo, Daniela
Campos, Ana Maria
Oliveira, Ricardo
Silva, Sónia Carina
Almeida, Carina
author_role author
author2 Barros, Maria Margarida
Araújo, Daniela
Campos, Ana Maria
Oliveira, Ricardo
Silva, Sónia Carina
Almeida, Carina
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Castro, Joana
Barros, Maria Margarida
Araújo, Daniela
Campos, Ana Maria
Oliveira, Ricardo
Silva, Sónia Carina
Almeida, Carina
dc.subject.por.fl_str_mv enteric colibacillosis
post-weaning diarrhea
gutmicrobiome
antibiotic therapy
zinc oxide
novel antimicrobial approaches
topic enteric colibacillosis
post-weaning diarrhea
gutmicrobiome
antibiotic therapy
zinc oxide
novel antimicrobial approaches
description The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fvets.2022.981207/full#supplementary-material
publishDate 2022
dc.date.none.fl_str_mv 2022-10-28
2022-10-28T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/82632
url https://hdl.handle.net/1822/82632
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Castro, J., Barros, M. M., Araújo, D., Campos, A. M., Oliveira, R., Silva, S., & Almeida, C. (2022, October 28). Swine enteric colibacillosis: Current treatment avenues and future directions. Frontiers in Veterinary Science. Frontiers Media SA. http://doi.org/10.3389/fvets.2022.981207
2297-1769
10.3389/fvets.2022.981207
981207
https://www.frontiersin.org/articles/10.3389/fvets.2022.981207/full
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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