KRAS as a modulator of the inflammatory tumor microenvironment: therapeutic implications
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/78321 |
Resumo: | KRAS mutations are one of the most frequent oncogenic mutations of all human cancers, being more prevalent in pancreatic, colorectal, and lung cancers. Intensive efforts have been encouraged in order to understand the effect of KRAS mutations, not only on tumor cells but also on the dynamic network composed by the tumor microenvironment (TME). The relevance of the TME in cancer biology has been increasing due to its impact on the modulation of cancer cell activities, which can dictate the success of tumor progression. Here, we aimed to clarify the pro- and anti-inflammatory role of KRAS mutations over the TME, detailing the context and the signaling pathways involved. In this review, we expect to open new avenues for investigating the potential of KRAS mutations on inflammatory TME modulation, opening a different vision of therapeutic combined approaches to overcome KRAS-associated therapy inefficacy and resistance in cancer. |
id |
RCAP_28d00de9b89d3e7262992220a76afbed |
---|---|
oai_identifier_str |
oai:repositorium.sdum.uminho.pt:1822/78321 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
KRAS as a modulator of the inflammatory tumor microenvironment: therapeutic implicationsKRAS mutationstumor microenvironmentinflammationpancreatic cancercolorectal cancerlung cancertherapyCiências Naturais::Ciências BiológicasScience & TechnologyKRAS mutations are one of the most frequent oncogenic mutations of all human cancers, being more prevalent in pancreatic, colorectal, and lung cancers. Intensive efforts have been encouraged in order to understand the effect of KRAS mutations, not only on tumor cells but also on the dynamic network composed by the tumor microenvironment (TME). The relevance of the TME in cancer biology has been increasing due to its impact on the modulation of cancer cell activities, which can dictate the success of tumor progression. Here, we aimed to clarify the pro- and anti-inflammatory role of KRAS mutations over the TME, detailing the context and the signaling pathways involved. In this review, we expect to open new avenues for investigating the potential of KRAS mutations on inflammatory TME modulation, opening a different vision of therapeutic combined approaches to overcome KRAS-associated therapy inefficacy and resistance in cancer.This work was financed by the Portuguese Foundation for Science and Technology (Fundacao para a Ciencia e a Tecnologia, FCT) within the scope of two PhD grants, SFRH/BD/140137/2018 attributed to FP and SFRH/BD/142486/2018 attributed to AF. A.P. acknownledges FCT within the scope of the project PTDC/QUIQIN/28662/2017. A.P. and M.J.S. also acknowledge the support of the CBMA strategic programme "Contrato-Programa" UIDB/04050/2020 funded by national funds through the FCT I.P. C.A.R. acknowledges the project Norte-01-0145-FEDER-000051-"Cancer Research on Therapy Resistance: From Basic Mechanisms to Novel Targets", supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (FEDER). M.J.O. acknowledges FEDER funds through COMPETE 2020-Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, Portuguese funds through FCT/Ministerio da Ciencia, Tecnologia e do Ensino Superior in the framework of the project POCI-01-0145-FEDER-31859/2017.Multidisciplinary Digital Publishing InstituteUniversidade do MinhoPereira, FláviaFerreira, AnabelaReis, Celso AlbuquerqueSousa, Maria JoãoOliveira, Maria JoséPreto, Ana2022-012022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/78321engPereira, F.; Ferreira, A.; Reis, C.A.; Sousa, M.J.; Oliveira, M.J.; Preto, A. KRAS as a Modulator of the Inflammatory Tumor Microenvironment: Therapeutic Implications. Cells 2022, 11, 398. https://doi.org/10.3390/cells110303982073-440910.3390/cells1103039835159208https://www.mdpi.com/2073-4409/11/3/398info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:45:26Zoai:repositorium.sdum.uminho.pt:1822/78321Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:43:17.282293Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
KRAS as a modulator of the inflammatory tumor microenvironment: therapeutic implications |
title |
KRAS as a modulator of the inflammatory tumor microenvironment: therapeutic implications |
spellingShingle |
KRAS as a modulator of the inflammatory tumor microenvironment: therapeutic implications Pereira, Flávia KRAS mutations tumor microenvironment inflammation pancreatic cancer colorectal cancer lung cancer therapy Ciências Naturais::Ciências Biológicas Science & Technology |
title_short |
KRAS as a modulator of the inflammatory tumor microenvironment: therapeutic implications |
title_full |
KRAS as a modulator of the inflammatory tumor microenvironment: therapeutic implications |
title_fullStr |
KRAS as a modulator of the inflammatory tumor microenvironment: therapeutic implications |
title_full_unstemmed |
KRAS as a modulator of the inflammatory tumor microenvironment: therapeutic implications |
title_sort |
KRAS as a modulator of the inflammatory tumor microenvironment: therapeutic implications |
author |
Pereira, Flávia |
author_facet |
Pereira, Flávia Ferreira, Anabela Reis, Celso Albuquerque Sousa, Maria João Oliveira, Maria José Preto, Ana |
author_role |
author |
author2 |
Ferreira, Anabela Reis, Celso Albuquerque Sousa, Maria João Oliveira, Maria José Preto, Ana |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Pereira, Flávia Ferreira, Anabela Reis, Celso Albuquerque Sousa, Maria João Oliveira, Maria José Preto, Ana |
dc.subject.por.fl_str_mv |
KRAS mutations tumor microenvironment inflammation pancreatic cancer colorectal cancer lung cancer therapy Ciências Naturais::Ciências Biológicas Science & Technology |
topic |
KRAS mutations tumor microenvironment inflammation pancreatic cancer colorectal cancer lung cancer therapy Ciências Naturais::Ciências Biológicas Science & Technology |
description |
KRAS mutations are one of the most frequent oncogenic mutations of all human cancers, being more prevalent in pancreatic, colorectal, and lung cancers. Intensive efforts have been encouraged in order to understand the effect of KRAS mutations, not only on tumor cells but also on the dynamic network composed by the tumor microenvironment (TME). The relevance of the TME in cancer biology has been increasing due to its impact on the modulation of cancer cell activities, which can dictate the success of tumor progression. Here, we aimed to clarify the pro- and anti-inflammatory role of KRAS mutations over the TME, detailing the context and the signaling pathways involved. In this review, we expect to open new avenues for investigating the potential of KRAS mutations on inflammatory TME modulation, opening a different vision of therapeutic combined approaches to overcome KRAS-associated therapy inefficacy and resistance in cancer. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01 2022-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/78321 |
url |
https://hdl.handle.net/1822/78321 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pereira, F.; Ferreira, A.; Reis, C.A.; Sousa, M.J.; Oliveira, M.J.; Preto, A. KRAS as a Modulator of the Inflammatory Tumor Microenvironment: Therapeutic Implications. Cells 2022, 11, 398. https://doi.org/10.3390/cells11030398 2073-4409 10.3390/cells11030398 35159208 https://www.mdpi.com/2073-4409/11/3/398 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799132988810723328 |