Germline Genetic Variants of the Renin-Angiotensin System, Hypoxia and Angiogenesis in Non-Small Cell Lung Cancer Progression: Discovery and Validation Studies

Detalhes bibliográficos
Autor(a) principal: Catarata, Maria Joana
Data de Publicação: 2020
Outros Autores: Medeiros, Rui, Oliveira, Maria José, Pêgo, Alice, Frade, João Gonçalo, Martins, Maria de Fátima, Cordeiro, Carlos Robalo, Herth, Felix J. F., Thomas, Michael, Kriegsmann, Mark, Meister, Michael, Schneider, Marc A, Muley, Thomas, Ribeiro, Ricardo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/105854
https://doi.org/10.3390/cancers12123834
Resumo: The renin-angiotensin system (RAS) is involved in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. Our aim was to study the association of putatively functional genetic polymorphisms in genes coding for proteins involved in RAS, hypoxia and angiogenesis with non-small cell lung cancer (NSCLC) prognosis.
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spelling Germline Genetic Variants of the Renin-Angiotensin System, Hypoxia and Angiogenesis in Non-Small Cell Lung Cancer Progression: Discovery and Validation Studiesgenetic polymorphismslung cancerrenin–angiotensinhypoxiaangiogenesisThe renin-angiotensin system (RAS) is involved in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. Our aim was to study the association of putatively functional genetic polymorphisms in genes coding for proteins involved in RAS, hypoxia and angiogenesis with non-small cell lung cancer (NSCLC) prognosis.MDPI2020-12-18info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/105854http://hdl.handle.net/10316/105854https://doi.org/10.3390/cancers12123834eng2072-6694Catarata, Maria JoanaMedeiros, RuiOliveira, Maria JoséPêgo, AliceFrade, João GonçaloMartins, Maria de FátimaCordeiro, Carlos RobaloHerth, Felix J. F.Thomas, MichaelKriegsmann, MarkMeister, MichaelSchneider, Marc AMuley, ThomasRibeiro, Ricardoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T21:31:30ZPortal AgregadorONG
dc.title.none.fl_str_mv Germline Genetic Variants of the Renin-Angiotensin System, Hypoxia and Angiogenesis in Non-Small Cell Lung Cancer Progression: Discovery and Validation Studies
title Germline Genetic Variants of the Renin-Angiotensin System, Hypoxia and Angiogenesis in Non-Small Cell Lung Cancer Progression: Discovery and Validation Studies
spellingShingle Germline Genetic Variants of the Renin-Angiotensin System, Hypoxia and Angiogenesis in Non-Small Cell Lung Cancer Progression: Discovery and Validation Studies
Catarata, Maria Joana
genetic polymorphisms
lung cancer
renin–angiotensin
hypoxia
angiogenesis
title_short Germline Genetic Variants of the Renin-Angiotensin System, Hypoxia and Angiogenesis in Non-Small Cell Lung Cancer Progression: Discovery and Validation Studies
title_full Germline Genetic Variants of the Renin-Angiotensin System, Hypoxia and Angiogenesis in Non-Small Cell Lung Cancer Progression: Discovery and Validation Studies
title_fullStr Germline Genetic Variants of the Renin-Angiotensin System, Hypoxia and Angiogenesis in Non-Small Cell Lung Cancer Progression: Discovery and Validation Studies
title_full_unstemmed Germline Genetic Variants of the Renin-Angiotensin System, Hypoxia and Angiogenesis in Non-Small Cell Lung Cancer Progression: Discovery and Validation Studies
title_sort Germline Genetic Variants of the Renin-Angiotensin System, Hypoxia and Angiogenesis in Non-Small Cell Lung Cancer Progression: Discovery and Validation Studies
author Catarata, Maria Joana
author_facet Catarata, Maria Joana
Medeiros, Rui
Oliveira, Maria José
Pêgo, Alice
Frade, João Gonçalo
Martins, Maria de Fátima
Cordeiro, Carlos Robalo
Herth, Felix J. F.
Thomas, Michael
Kriegsmann, Mark
Meister, Michael
Schneider, Marc A
Muley, Thomas
Ribeiro, Ricardo
author_role author
author2 Medeiros, Rui
Oliveira, Maria José
Pêgo, Alice
Frade, João Gonçalo
Martins, Maria de Fátima
Cordeiro, Carlos Robalo
Herth, Felix J. F.
Thomas, Michael
Kriegsmann, Mark
Meister, Michael
Schneider, Marc A
Muley, Thomas
Ribeiro, Ricardo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Catarata, Maria Joana
Medeiros, Rui
Oliveira, Maria José
Pêgo, Alice
Frade, João Gonçalo
Martins, Maria de Fátima
Cordeiro, Carlos Robalo
Herth, Felix J. F.
Thomas, Michael
Kriegsmann, Mark
Meister, Michael
Schneider, Marc A
Muley, Thomas
Ribeiro, Ricardo
dc.subject.por.fl_str_mv genetic polymorphisms
lung cancer
renin–angiotensin
hypoxia
angiogenesis
topic genetic polymorphisms
lung cancer
renin–angiotensin
hypoxia
angiogenesis
description The renin-angiotensin system (RAS) is involved in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. Our aim was to study the association of putatively functional genetic polymorphisms in genes coding for proteins involved in RAS, hypoxia and angiogenesis with non-small cell lung cancer (NSCLC) prognosis.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-18
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/105854
http://hdl.handle.net/10316/105854
https://doi.org/10.3390/cancers12123834
url http://hdl.handle.net/10316/105854
https://doi.org/10.3390/cancers12123834
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2072-6694
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.mail.fl_str_mv
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