Kidney transplantation in a patient with preformed and exclusively anti-HLA-Cw donor specific antibody
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.16/2245 |
Resumo: | We report a patient who had received a first kidney transplant and had preformed DSA anti-HLA-Cw, developing AMR C4d+ soon after transplant. Classically anti-HLA-Cw are considered less immunogenic and are not considered in many organ allocation systems or immunologic risk stratification algorithms, including in Portugal. However, data from literature confirms that their presence is as deleterious as DSA anti-HLA A/B/DR/DQ. Thus we should take HLA-C typing and respective antibody identification into account in sensitized patients, in order to access risk stratification and establish the need for correct induction or desensitization therapies. |
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Kidney transplantation in a patient with preformed and exclusively anti-HLA-Cw donor specific antibodyDonor-specific antibodies (DSA)Anti-HLA-Cw antibodiesAntibody-mediated rejection (AMR)We report a patient who had received a first kidney transplant and had preformed DSA anti-HLA-Cw, developing AMR C4d+ soon after transplant. Classically anti-HLA-Cw are considered less immunogenic and are not considered in many organ allocation systems or immunologic risk stratification algorithms, including in Portugal. However, data from literature confirms that their presence is as deleterious as DSA anti-HLA A/B/DR/DQ. Thus we should take HLA-C typing and respective antibody identification into account in sensitized patients, in order to access risk stratification and establish the need for correct induction or desensitization therapies.Sociedade Portuguesa de NefrologiaRepositório Científico do Centro Hospitalar Universitário de Santo AntónioSantos, S.Castro, A.Campos, A.Pedroso, S.Dias, L.Castro-Henriques, A.2018-10-30T12:25:20Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/2245engPort J Nephrol Hypert 2017; 31(1): 50-532183-1289info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-20T10:59:44Zoai:repositorio.chporto.pt:10400.16/2245Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:38:28.077827Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Kidney transplantation in a patient with preformed and exclusively anti-HLA-Cw donor specific antibody |
title |
Kidney transplantation in a patient with preformed and exclusively anti-HLA-Cw donor specific antibody |
spellingShingle |
Kidney transplantation in a patient with preformed and exclusively anti-HLA-Cw donor specific antibody Santos, S. Donor-specific antibodies (DSA) Anti-HLA-Cw antibodies Antibody-mediated rejection (AMR) |
title_short |
Kidney transplantation in a patient with preformed and exclusively anti-HLA-Cw donor specific antibody |
title_full |
Kidney transplantation in a patient with preformed and exclusively anti-HLA-Cw donor specific antibody |
title_fullStr |
Kidney transplantation in a patient with preformed and exclusively anti-HLA-Cw donor specific antibody |
title_full_unstemmed |
Kidney transplantation in a patient with preformed and exclusively anti-HLA-Cw donor specific antibody |
title_sort |
Kidney transplantation in a patient with preformed and exclusively anti-HLA-Cw donor specific antibody |
author |
Santos, S. |
author_facet |
Santos, S. Castro, A. Campos, A. Pedroso, S. Dias, L. Castro-Henriques, A. |
author_role |
author |
author2 |
Castro, A. Campos, A. Pedroso, S. Dias, L. Castro-Henriques, A. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Centro Hospitalar Universitário de Santo António |
dc.contributor.author.fl_str_mv |
Santos, S. Castro, A. Campos, A. Pedroso, S. Dias, L. Castro-Henriques, A. |
dc.subject.por.fl_str_mv |
Donor-specific antibodies (DSA) Anti-HLA-Cw antibodies Antibody-mediated rejection (AMR) |
topic |
Donor-specific antibodies (DSA) Anti-HLA-Cw antibodies Antibody-mediated rejection (AMR) |
description |
We report a patient who had received a first kidney transplant and had preformed DSA anti-HLA-Cw, developing AMR C4d+ soon after transplant. Classically anti-HLA-Cw are considered less immunogenic and are not considered in many organ allocation systems or immunologic risk stratification algorithms, including in Portugal. However, data from literature confirms that their presence is as deleterious as DSA anti-HLA A/B/DR/DQ. Thus we should take HLA-C typing and respective antibody identification into account in sensitized patients, in order to access risk stratification and establish the need for correct induction or desensitization therapies. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z 2018-10-30T12:25:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.16/2245 |
url |
http://hdl.handle.net/10400.16/2245 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Port J Nephrol Hypert 2017; 31(1): 50-53 2183-1289 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Nefrologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Nefrologia |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133645736247296 |