Bioengineered hyaluronan hydrogels for the delivery of molecular and cellular therapies

Detalhes bibliográficos
Autor(a) principal: Silva, J
Data de Publicação: 2023
Outros Autores: Azevedo, HS
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/153469
Resumo: Hyaluronan (HA) is an extracellular matrix (ECM)-based polymer with unique physicochemical properties including biocompatibility, biodegradability, viscoelasticity, and high-water retention. However, its solubility in water drastically reduces its half-life in vivo. Through judicious chemical modifications, its structure is easily crosslinked and can conjugate with numerous therapeutic molecules, extending their therapeutic function. Throughout this review, an overview of crosslinking methods to create HA hydrogels is provided, including covalent (permanent, transient/dynamic) and non-covalent chemistries, as well as the use of non-modified HA in supramolecular hydrogels. HA-based injectable hydrogels are very appealing as a three-dimensional network for the delivery of therapeutic molecules (drugs and biomolecules) and stem cells. HA hydrogels are capable of mimicking important features of the native ECM and can provide spatiotemporal signals to regulate cell fate. The final part of the review also describes the application of HA hydrogels as vehicles for delivering stem cells and therapeutics, capable of modulating cell behavior.
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spelling Bioengineered hyaluronan hydrogels for the delivery of molecular and cellular therapiesHyaluronic acidInjectable hydrogelsTherapeutic moleculeStem cellsHyaluronan (HA) is an extracellular matrix (ECM)-based polymer with unique physicochemical properties including biocompatibility, biodegradability, viscoelasticity, and high-water retention. However, its solubility in water drastically reduces its half-life in vivo. Through judicious chemical modifications, its structure is easily crosslinked and can conjugate with numerous therapeutic molecules, extending their therapeutic function. Throughout this review, an overview of crosslinking methods to create HA hydrogels is provided, including covalent (permanent, transient/dynamic) and non-covalent chemistries, as well as the use of non-modified HA in supramolecular hydrogels. HA-based injectable hydrogels are very appealing as a three-dimensional network for the delivery of therapeutic molecules (drugs and biomolecules) and stem cells. HA hydrogels are capable of mimicking important features of the native ECM and can provide spatiotemporal signals to regulate cell fate. The final part of the review also describes the application of HA hydrogels as vehicles for delivering stem cells and therapeutics, capable of modulating cell behavior.Wiley2023-09-112023-09-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/153469eng2366-398710.1002/adtp.202300182Silva, JAzevedo, HSinfo:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T13:31:35Zoai:repositorio-aberto.up.pt:10216/153469Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:41:55.574261Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Bioengineered hyaluronan hydrogels for the delivery of molecular and cellular therapies
title Bioengineered hyaluronan hydrogels for the delivery of molecular and cellular therapies
spellingShingle Bioengineered hyaluronan hydrogels for the delivery of molecular and cellular therapies
Silva, J
Hyaluronic acid
Injectable hydrogels
Therapeutic molecule
Stem cells
title_short Bioengineered hyaluronan hydrogels for the delivery of molecular and cellular therapies
title_full Bioengineered hyaluronan hydrogels for the delivery of molecular and cellular therapies
title_fullStr Bioengineered hyaluronan hydrogels for the delivery of molecular and cellular therapies
title_full_unstemmed Bioengineered hyaluronan hydrogels for the delivery of molecular and cellular therapies
title_sort Bioengineered hyaluronan hydrogels for the delivery of molecular and cellular therapies
author Silva, J
author_facet Silva, J
Azevedo, HS
author_role author
author2 Azevedo, HS
author2_role author
dc.contributor.author.fl_str_mv Silva, J
Azevedo, HS
dc.subject.por.fl_str_mv Hyaluronic acid
Injectable hydrogels
Therapeutic molecule
Stem cells
topic Hyaluronic acid
Injectable hydrogels
Therapeutic molecule
Stem cells
description Hyaluronan (HA) is an extracellular matrix (ECM)-based polymer with unique physicochemical properties including biocompatibility, biodegradability, viscoelasticity, and high-water retention. However, its solubility in water drastically reduces its half-life in vivo. Through judicious chemical modifications, its structure is easily crosslinked and can conjugate with numerous therapeutic molecules, extending their therapeutic function. Throughout this review, an overview of crosslinking methods to create HA hydrogels is provided, including covalent (permanent, transient/dynamic) and non-covalent chemistries, as well as the use of non-modified HA in supramolecular hydrogels. HA-based injectable hydrogels are very appealing as a three-dimensional network for the delivery of therapeutic molecules (drugs and biomolecules) and stem cells. HA hydrogels are capable of mimicking important features of the native ECM and can provide spatiotemporal signals to regulate cell fate. The final part of the review also describes the application of HA hydrogels as vehicles for delivering stem cells and therapeutics, capable of modulating cell behavior.
publishDate 2023
dc.date.none.fl_str_mv 2023-09-11
2023-09-11T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/153469
url https://hdl.handle.net/10216/153469
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2366-3987
10.1002/adtp.202300182
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
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dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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