Genetic diversity, transmission dynamics and drug resistance of Mycobacterium tuberculosis in Angola

Detalhes bibliográficos
Autor(a) principal: Perdigão, João
Data de Publicação: 2017
Outros Autores: Clemente, Sofia, Ramos, Jorge, Masakidi, Pedro, Machado, Diana, Silva, Carla, Couto, Isabel, Viveiros, Miguel, Taveira, Nuno, Portugal, Isabel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.26/18162
Resumo: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
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spelling Genetic diversity, transmission dynamics and drug resistance of Mycobacterium tuberculosis in AngolaClinical microbiologyTuberculosisMycobacterium tuberculosisAngolaThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/"Tuberculosis (TB) poses a serious public health problem in Angola. No surveillance data on drug resistance is available and nothing is known regarding the genetic diversity and population structure of circulating Mycobacterium tuberculosis strains. Here, we have genotyped and evaluated drug susceptibility of 89 Mycobacterium tuberculosis clinical isolates from Luanda. Thirty-three different spoligotype profiles corresponding to 24 different Shared International Types (SIT) and 9 orphan profiles were detected. SIT 20 (LAM1) was the most prevalent (n = 16, 18.2%) followed by SIT 42 (LAM9; n = 15, 17.1%). Overall, the M. tuberculosis population structure in this sample was dominated by LAM (64.8%) and T (33.0%) strains. Twenty-four-loci MIRU-VNTR analysis revealed that a total of 13 isolates were grouped in 5 distinct clusters. Drug susceptibility data showed that 22 (24.7%) of the 89 clinical isolates were resistant to one or more antibacillary drugs of which 4 (4.5%) were multidrug resistant. In conclusion, this study demonstrates a high predominance of LAM strains circulating in the Luanda setting and the presence of recent transmission events. The rate and the emergence dynamics of drug resistant TB found in this sample are significant and highlight the need of further studies specifically focused on MDR-TB transmission."Springer NatureRepositório ComumPerdigão, JoãoClemente, SofiaRamos, JorgeMasakidi, PedroMachado, DianaSilva, CarlaCouto, IsabelViveiros, MiguelTaveira, NunoPortugal, Isabel2017-04-06T13:05:34Z2017-02-01T00:00:00Z2017-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/18162engPerdigão, J. et al. Genetic diversity, transmission dynamics and drug resistance of Mycobacterium tuberculosis in Angola. Sci. Rep. 7, 42814; doi: 10.1038/srep42814 (2017).2045-232210.1038/srep42814info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-06T14:52:48Zoai:comum.rcaap.pt:10400.26/18162Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:08:50.023045Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Genetic diversity, transmission dynamics and drug resistance of Mycobacterium tuberculosis in Angola
title Genetic diversity, transmission dynamics and drug resistance of Mycobacterium tuberculosis in Angola
spellingShingle Genetic diversity, transmission dynamics and drug resistance of Mycobacterium tuberculosis in Angola
Perdigão, João
Clinical microbiology
Tuberculosis
Mycobacterium tuberculosis
Angola
title_short Genetic diversity, transmission dynamics and drug resistance of Mycobacterium tuberculosis in Angola
title_full Genetic diversity, transmission dynamics and drug resistance of Mycobacterium tuberculosis in Angola
title_fullStr Genetic diversity, transmission dynamics and drug resistance of Mycobacterium tuberculosis in Angola
title_full_unstemmed Genetic diversity, transmission dynamics and drug resistance of Mycobacterium tuberculosis in Angola
title_sort Genetic diversity, transmission dynamics and drug resistance of Mycobacterium tuberculosis in Angola
author Perdigão, João
author_facet Perdigão, João
Clemente, Sofia
Ramos, Jorge
Masakidi, Pedro
Machado, Diana
Silva, Carla
Couto, Isabel
Viveiros, Miguel
Taveira, Nuno
Portugal, Isabel
author_role author
author2 Clemente, Sofia
Ramos, Jorge
Masakidi, Pedro
Machado, Diana
Silva, Carla
Couto, Isabel
Viveiros, Miguel
Taveira, Nuno
Portugal, Isabel
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Perdigão, João
Clemente, Sofia
Ramos, Jorge
Masakidi, Pedro
Machado, Diana
Silva, Carla
Couto, Isabel
Viveiros, Miguel
Taveira, Nuno
Portugal, Isabel
dc.subject.por.fl_str_mv Clinical microbiology
Tuberculosis
Mycobacterium tuberculosis
Angola
topic Clinical microbiology
Tuberculosis
Mycobacterium tuberculosis
Angola
description This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
publishDate 2017
dc.date.none.fl_str_mv 2017-04-06T13:05:34Z
2017-02-01T00:00:00Z
2017-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/18162
url http://hdl.handle.net/10400.26/18162
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Perdigão, J. et al. Genetic diversity, transmission dynamics and drug resistance of Mycobacterium tuberculosis in Angola. Sci. Rep. 7, 42814; doi: 10.1038/srep42814 (2017).
2045-2322
10.1038/srep42814
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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