Predominance of influenza virus A(H3N2) 3C.2a1b and A(H1N1)pdm09 6B.1A5A genetic subclades in the WHO European Region, 2018–2019
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.18/7630 |
Resumo: | Network authors: Portugal - Raquel Guiomar, Pedro Pechirra, National Influenza Reference Laboratory, Infectious Diseases Department, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal |
| id |
RCAP_30e74b484ae5dc5ace9818f242fe1ce9 |
|---|---|
| oai_identifier_str |
oai:repositorio.insa.pt:10400.18/7630 |
| network_acronym_str |
RCAP |
| network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository_id_str |
7160 |
| spelling |
Predominance of influenza virus A(H3N2) 3C.2a1b and A(H1N1)pdm09 6B.1A5A genetic subclades in the WHO European Region, 2018–2019AntigenicEuropeGeneticInfluenzaSurveillanceVaccineInfecções RespiratóriasNetwork authors: Portugal - Raquel Guiomar, Pedro Pechirra, National Influenza Reference Laboratory, Infectious Diseases Department, National Institute of Health Dr. Ricardo Jorge, Lisbon, PortugalBackground: The 2018/2019 influenza season in the WHO European Region was dominated by influenza A (H1N1)pdm09 and (H3N2) viruses, with very few influenza B viruses detected. Methods: Countries in the European Region reported virus characterization data to The European Surveillance System for weeks 40/2018 to 20/2019. These virus antigenic and genetic characterization and haemagglutinin (HA) sequence data were analysed to describe and assess circulating viruses relative to the 2018/2019 vaccine virus components for the northern hemisphere. Results: Thirty countries reported 4776 viruses characterized genetically and 3311 viruses antigenically. All genetically characterized A(H1N1)pdm09 viruses fell in subclade 6B.1A, of which 90% carried the amino acid substitution S183P in the HA gene. Antigenic data indicated that circulating A(H1N1)pdm09 viruses were similar to the 2018/2019 vaccine virus. Genetic data showed that A(H3N2) viruses mostly fell in clade 3C.2a (75%) and 90% of which were subclade 3C.2a1b. A lower proportion fell in clade 3C.3a (23%) and were antigenically distinct from the vaccine virus. All B/Victoria viruses belonged to clade 1A; 30% carried a double amino acid deletion in HA and were genetically and antigenically similar to the vaccine virus component, while 55% carried a triple amino acid deletion or no deletion in HA; these were antigenically distinct from each other and from the vaccine component. All B/Yamagata viruses belonged to clade 3 and were antigenically similar to the virus component in the quadrivalent vaccine for 2018/2019. Conclusions: A simultaneous circulation of genetically and antigenically diverse A(H3N2) and B/Victoria viruses was observed and represented a challenge to vaccine strain selection.Highlights: Co-circulation of different clades/subclades of influenza A viruses in 2018/2019 in the Region; Most circulating A(H1N1)pdm09 viruses (6B.1A) carried S183P in hemagglutinin; Genetically heterogeneous A(H3N2) viruses, with co-circulation of clades 3C.2a and 3C.3a; Antigenically distinct A(H3N2) clade 3C.3a viruses were increasingly detected until 02/2019 and then decreased; Co-circulation of genetically and antigenically diverse A(H3N2) strains challenges vaccine strain selection.Repositório Científico do Instituto Nacional de SaúdeMelidou, AngelikiHungnes, OlavPereyaslov, DmitriyAdlhoch, CorneliaSegaloff, HannahRobesyn, EmmanuelPenttinen, PasiOlsen, Sonja J.Redlberger-Fritz, MonikaPopow-Kraupp, ThereseHasibra, IrisSimaku, ArtanThomas, IsabelleBarbezange, CyrilDedeić-Ljubović, AmelaRodić-Vukmir, NinaKorsun, NeliAngenova, SvetlaDraženović, VladimirKoliou, MariaPieridou, DespoHavlickova, MartinaNagy, AlexanderTrebbien, RamonaGaliano, MonicaThompson, CatherineIkonen, NiinaHaveri, AnuBehillil, SylvieEnouf, VincentValette, MartineLina, BrunoGavashelidze, MariMachablishvili, AnnGioula, GeorgiaExindari, MariaKossyvakis, AthanasiosMentis, AndreasDürrwald, RalfZsuzsanna, MolnarMonika, RozsaLöve, ArthurErna, GudrunDunford, LindaFitzpatrick, SarahCastrucci, Maria RitaPuzelli, SimonaSagymbay, AltynayNussupbayeva, GaukharZamjatina, NatalijaPakarna, GatisGriskevičius, AlgirdasSkrickiene, AstaFournier, GuillaumeMossong, JoelMelillo, JackieZahra, GraziellaMeijer, AdamFouchier, RonMcCaughey, ConallO'Doherty, MarkBragstad, KarolineGuiomar, RaquelPechirra, PedroApostol, MarianaAlina, DrucLazar, MihaelaMaria, Cherciu CarmenKomissarov, AndreyBurtseva, ElenaGunson, Rory N.Shepherd, SamanthaTichá, ElenaStaronova, EditaProsenc, KatarinaBerginc, NatašaPozo, FranciscoCasas, InmaculadaBrytting, MiaWiman, ÅsaGonçalves, Ana RitaDemchyshyna, IrynaMironenko, AllaMoore, CatherineCottrell, SimonEuropean Region influenza surveillance network2021-04-02T16:36:46Z2020-07-312020-07-31T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/7630engVaccine. 2020 Jul 31;38(35):5707-5717. doi: 10.1016/j.vaccine.2020.06.031. Epub 2020 Jul 3.0264-410X10.1016/j.vaccine.2020.06.031info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:07Zoai:repositorio.insa.pt:10400.18/7630Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:42:15.927974Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Predominance of influenza virus A(H3N2) 3C.2a1b and A(H1N1)pdm09 6B.1A5A genetic subclades in the WHO European Region, 2018–2019 |
| title |
Predominance of influenza virus A(H3N2) 3C.2a1b and A(H1N1)pdm09 6B.1A5A genetic subclades in the WHO European Region, 2018–2019 |
| spellingShingle |
Predominance of influenza virus A(H3N2) 3C.2a1b and A(H1N1)pdm09 6B.1A5A genetic subclades in the WHO European Region, 2018–2019 Melidou, Angeliki Antigenic Europe Genetic Influenza Surveillance Vaccine Infecções Respiratórias |
| title_short |
Predominance of influenza virus A(H3N2) 3C.2a1b and A(H1N1)pdm09 6B.1A5A genetic subclades in the WHO European Region, 2018–2019 |
| title_full |
Predominance of influenza virus A(H3N2) 3C.2a1b and A(H1N1)pdm09 6B.1A5A genetic subclades in the WHO European Region, 2018–2019 |
| title_fullStr |
Predominance of influenza virus A(H3N2) 3C.2a1b and A(H1N1)pdm09 6B.1A5A genetic subclades in the WHO European Region, 2018–2019 |
| title_full_unstemmed |
Predominance of influenza virus A(H3N2) 3C.2a1b and A(H1N1)pdm09 6B.1A5A genetic subclades in the WHO European Region, 2018–2019 |
| title_sort |
Predominance of influenza virus A(H3N2) 3C.2a1b and A(H1N1)pdm09 6B.1A5A genetic subclades in the WHO European Region, 2018–2019 |
| author |
Melidou, Angeliki |
| author_facet |
Melidou, Angeliki Hungnes, Olav Pereyaslov, Dmitriy Adlhoch, Cornelia Segaloff, Hannah Robesyn, Emmanuel Penttinen, Pasi Olsen, Sonja J. Redlberger-Fritz, Monika Popow-Kraupp, Therese Hasibra, Iris Simaku, Artan Thomas, Isabelle Barbezange, Cyril Dedeić-Ljubović, Amela Rodić-Vukmir, Nina Korsun, Neli Angenova, Svetla Draženović, Vladimir Koliou, Maria Pieridou, Despo Havlickova, Martina Nagy, Alexander Trebbien, Ramona Galiano, Monica Thompson, Catherine Ikonen, Niina Haveri, Anu Behillil, Sylvie Enouf, Vincent Valette, Martine Lina, Bruno Gavashelidze, Mari Machablishvili, Ann Gioula, Georgia Exindari, Maria Kossyvakis, Athanasios Mentis, Andreas Dürrwald, Ralf Zsuzsanna, Molnar Monika, Rozsa Löve, Arthur Erna, Gudrun Dunford, Linda Fitzpatrick, Sarah Castrucci, Maria Rita Puzelli, Simona Sagymbay, Altynay Nussupbayeva, Gaukhar Zamjatina, Natalija Pakarna, Gatis Griskevičius, Algirdas Skrickiene, Asta Fournier, Guillaume Mossong, Joel Melillo, Jackie Zahra, Graziella Meijer, Adam Fouchier, Ron McCaughey, Conall O'Doherty, Mark Bragstad, Karoline Guiomar, Raquel Pechirra, Pedro Apostol, Mariana Alina, Druc Lazar, Mihaela Maria, Cherciu Carmen Komissarov, Andrey Burtseva, Elena Gunson, Rory N. Shepherd, Samantha Tichá, Elena Staronova, Edita Prosenc, Katarina Berginc, Nataša Pozo, Francisco Casas, Inmaculada Brytting, Mia Wiman, Åsa Gonçalves, Ana Rita Demchyshyna, Iryna Mironenko, Alla Moore, Catherine Cottrell, Simon European Region influenza surveillance network |
| author_role |
author |
| author2 |
Hungnes, Olav Pereyaslov, Dmitriy Adlhoch, Cornelia Segaloff, Hannah Robesyn, Emmanuel Penttinen, Pasi Olsen, Sonja J. Redlberger-Fritz, Monika Popow-Kraupp, Therese Hasibra, Iris Simaku, Artan Thomas, Isabelle Barbezange, Cyril Dedeić-Ljubović, Amela Rodić-Vukmir, Nina Korsun, Neli Angenova, Svetla Draženović, Vladimir Koliou, Maria Pieridou, Despo Havlickova, Martina Nagy, Alexander Trebbien, Ramona Galiano, Monica Thompson, Catherine Ikonen, Niina Haveri, Anu Behillil, Sylvie Enouf, Vincent Valette, Martine Lina, Bruno Gavashelidze, Mari Machablishvili, Ann Gioula, Georgia Exindari, Maria Kossyvakis, Athanasios Mentis, Andreas Dürrwald, Ralf Zsuzsanna, Molnar Monika, Rozsa Löve, Arthur Erna, Gudrun Dunford, Linda Fitzpatrick, Sarah Castrucci, Maria Rita Puzelli, Simona Sagymbay, Altynay Nussupbayeva, Gaukhar Zamjatina, Natalija Pakarna, Gatis Griskevičius, Algirdas Skrickiene, Asta Fournier, Guillaume Mossong, Joel Melillo, Jackie Zahra, Graziella Meijer, Adam Fouchier, Ron McCaughey, Conall O'Doherty, Mark Bragstad, Karoline Guiomar, Raquel Pechirra, Pedro Apostol, Mariana Alina, Druc Lazar, Mihaela Maria, Cherciu Carmen Komissarov, Andrey Burtseva, Elena Gunson, Rory N. Shepherd, Samantha Tichá, Elena Staronova, Edita Prosenc, Katarina Berginc, Nataša Pozo, Francisco Casas, Inmaculada Brytting, Mia Wiman, Åsa Gonçalves, Ana Rita Demchyshyna, Iryna Mironenko, Alla Moore, Catherine Cottrell, Simon European Region influenza surveillance network |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
Melidou, Angeliki Hungnes, Olav Pereyaslov, Dmitriy Adlhoch, Cornelia Segaloff, Hannah Robesyn, Emmanuel Penttinen, Pasi Olsen, Sonja J. Redlberger-Fritz, Monika Popow-Kraupp, Therese Hasibra, Iris Simaku, Artan Thomas, Isabelle Barbezange, Cyril Dedeić-Ljubović, Amela Rodić-Vukmir, Nina Korsun, Neli Angenova, Svetla Draženović, Vladimir Koliou, Maria Pieridou, Despo Havlickova, Martina Nagy, Alexander Trebbien, Ramona Galiano, Monica Thompson, Catherine Ikonen, Niina Haveri, Anu Behillil, Sylvie Enouf, Vincent Valette, Martine Lina, Bruno Gavashelidze, Mari Machablishvili, Ann Gioula, Georgia Exindari, Maria Kossyvakis, Athanasios Mentis, Andreas Dürrwald, Ralf Zsuzsanna, Molnar Monika, Rozsa Löve, Arthur Erna, Gudrun Dunford, Linda Fitzpatrick, Sarah Castrucci, Maria Rita Puzelli, Simona Sagymbay, Altynay Nussupbayeva, Gaukhar Zamjatina, Natalija Pakarna, Gatis Griskevičius, Algirdas Skrickiene, Asta Fournier, Guillaume Mossong, Joel Melillo, Jackie Zahra, Graziella Meijer, Adam Fouchier, Ron McCaughey, Conall O'Doherty, Mark Bragstad, Karoline Guiomar, Raquel Pechirra, Pedro Apostol, Mariana Alina, Druc Lazar, Mihaela Maria, Cherciu Carmen Komissarov, Andrey Burtseva, Elena Gunson, Rory N. Shepherd, Samantha Tichá, Elena Staronova, Edita Prosenc, Katarina Berginc, Nataša Pozo, Francisco Casas, Inmaculada Brytting, Mia Wiman, Åsa Gonçalves, Ana Rita Demchyshyna, Iryna Mironenko, Alla Moore, Catherine Cottrell, Simon European Region influenza surveillance network |
| dc.subject.por.fl_str_mv |
Antigenic Europe Genetic Influenza Surveillance Vaccine Infecções Respiratórias |
| topic |
Antigenic Europe Genetic Influenza Surveillance Vaccine Infecções Respiratórias |
| description |
Network authors: Portugal - Raquel Guiomar, Pedro Pechirra, National Influenza Reference Laboratory, Infectious Diseases Department, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-07-31 2020-07-31T00:00:00Z 2021-04-02T16:36:46Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/7630 |
| url |
http://hdl.handle.net/10400.18/7630 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Vaccine. 2020 Jul 31;38(35):5707-5717. doi: 10.1016/j.vaccine.2020.06.031. Epub 2020 Jul 3. 0264-410X 10.1016/j.vaccine.2020.06.031 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
| instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| instacron_str |
RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| repository.mail.fl_str_mv |
|
| _version_ |
1799132167296516096 |