Usefulness of TNFR1 As Biomarker of Intracranial Aneurysm in Patients with Spontaneous Subarachnoid Hemorrhage

Detalhes bibliográficos
Autor(a) principal: Torres, R
Data de Publicação: 2019
Outros Autores: Mancha, F, Bustamante, A, Canhao, P, Fragata, I, Montaner, J
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.17/3399
Resumo: Aim: To determine the utility of TNF-α receptor (TNFR1) as a biomarker for the presence of aneurysms in patients with acute subarachnoid hemorrhage (SAH). Patient & methods: This is a prospective study in patients with acute spontaneous SAH. Arterial blood from catheter near aneurysm and peripheral venous blood samples are collected. TNFR1 levels were analyzed in patients with and without aneurysm. Results: 80 patients were included, 58 were analyzed. 41 patients (70.7%) had an aneurysm. Venous TNFR1 levels >1658 pg/ml had 46.3% sensitivity and 94.1% specificity for aneurysms presence. TNFR1 >1658 pg/ml was also an independent predictor for its presence (odds ratio = 12.03 [1.13-128.16]; p = 0.039). Conclusion: High levels of TNFR1 in peripheral venous blood are associated with the presence of aneurysm in patients with acute SAH.
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spelling Usefulness of TNFR1 As Biomarker of Intracranial Aneurysm in Patients with Spontaneous Subarachnoid HemorrhageCHLC NRADAneurysmBiomarkerSpontaneous Subarachnoid HemorrhageStrokeTNFR1Aim: To determine the utility of TNF-α receptor (TNFR1) as a biomarker for the presence of aneurysms in patients with acute subarachnoid hemorrhage (SAH). Patient & methods: This is a prospective study in patients with acute spontaneous SAH. Arterial blood from catheter near aneurysm and peripheral venous blood samples are collected. TNFR1 levels were analyzed in patients with and without aneurysm. Results: 80 patients were included, 58 were analyzed. 41 patients (70.7%) had an aneurysm. Venous TNFR1 levels >1658 pg/ml had 46.3% sensitivity and 94.1% specificity for aneurysms presence. TNFR1 >1658 pg/ml was also an independent predictor for its presence (odds ratio = 12.03 [1.13-128.16]; p = 0.039). Conclusion: High levels of TNFR1 in peripheral venous blood are associated with the presence of aneurysm in patients with acute SAH.Future ScienceRepositório do Centro Hospitalar Universitário de Lisboa Central, EPETorres, RMancha, FBustamante, ACanhao, PFragata, IMontaner, J2020-01-14T15:50:23Z2019-11-052019-11-05T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/3399engFuture Sci OA. 2019 Nov 5;6(1):FSO431.10.2144/fsoa-2019-0090info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:42:48ZPortal AgregadorONG
dc.title.none.fl_str_mv Usefulness of TNFR1 As Biomarker of Intracranial Aneurysm in Patients with Spontaneous Subarachnoid Hemorrhage
title Usefulness of TNFR1 As Biomarker of Intracranial Aneurysm in Patients with Spontaneous Subarachnoid Hemorrhage
spellingShingle Usefulness of TNFR1 As Biomarker of Intracranial Aneurysm in Patients with Spontaneous Subarachnoid Hemorrhage
Torres, R
CHLC NRAD
Aneurysm
Biomarker
Spontaneous Subarachnoid Hemorrhage
Stroke
TNFR1
title_short Usefulness of TNFR1 As Biomarker of Intracranial Aneurysm in Patients with Spontaneous Subarachnoid Hemorrhage
title_full Usefulness of TNFR1 As Biomarker of Intracranial Aneurysm in Patients with Spontaneous Subarachnoid Hemorrhage
title_fullStr Usefulness of TNFR1 As Biomarker of Intracranial Aneurysm in Patients with Spontaneous Subarachnoid Hemorrhage
title_full_unstemmed Usefulness of TNFR1 As Biomarker of Intracranial Aneurysm in Patients with Spontaneous Subarachnoid Hemorrhage
title_sort Usefulness of TNFR1 As Biomarker of Intracranial Aneurysm in Patients with Spontaneous Subarachnoid Hemorrhage
author Torres, R
author_facet Torres, R
Mancha, F
Bustamante, A
Canhao, P
Fragata, I
Montaner, J
author_role author
author2 Mancha, F
Bustamante, A
Canhao, P
Fragata, I
Montaner, J
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE
dc.contributor.author.fl_str_mv Torres, R
Mancha, F
Bustamante, A
Canhao, P
Fragata, I
Montaner, J
dc.subject.por.fl_str_mv CHLC NRAD
Aneurysm
Biomarker
Spontaneous Subarachnoid Hemorrhage
Stroke
TNFR1
topic CHLC NRAD
Aneurysm
Biomarker
Spontaneous Subarachnoid Hemorrhage
Stroke
TNFR1
description Aim: To determine the utility of TNF-α receptor (TNFR1) as a biomarker for the presence of aneurysms in patients with acute subarachnoid hemorrhage (SAH). Patient & methods: This is a prospective study in patients with acute spontaneous SAH. Arterial blood from catheter near aneurysm and peripheral venous blood samples are collected. TNFR1 levels were analyzed in patients with and without aneurysm. Results: 80 patients were included, 58 were analyzed. 41 patients (70.7%) had an aneurysm. Venous TNFR1 levels >1658 pg/ml had 46.3% sensitivity and 94.1% specificity for aneurysms presence. TNFR1 >1658 pg/ml was also an independent predictor for its presence (odds ratio = 12.03 [1.13-128.16]; p = 0.039). Conclusion: High levels of TNFR1 in peripheral venous blood are associated with the presence of aneurysm in patients with acute SAH.
publishDate 2019
dc.date.none.fl_str_mv 2019-11-05
2019-11-05T00:00:00Z
2020-01-14T15:50:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/3399
url http://hdl.handle.net/10400.17/3399
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Future Sci OA. 2019 Nov 5;6(1):FSO431.
10.2144/fsoa-2019-0090
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Future Science
publisher.none.fl_str_mv Future Science
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.mail.fl_str_mv
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