Epicardial Adipose Tissue
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/127060 |
Resumo: | Publisher Copyright: © The Author(s) 2021. |
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Epicardial Adipose TissueThe Genetics Behind an Emerging Cardiovascular Risk Markeratherosclerosiscardiovascular risk factorsEpicardial adipose tissuegenetic polymorphismsGenetic Risk ScoreCardiology and Cardiovascular MedicineSDG 3 - Good Health and Well-beingPublisher Copyright: © The Author(s) 2021.Evidence points epicardial adipose tissue (EAT) as an emerging cardiovascular risk marker. Whether genetic polymorphisms linked with atherosclerosis are associated with higher EAT is still unknown. We aim to assess the role of genetic burden of atherosclerosis and its association to EAT in a cohort of asymptomatic individuals without coronary disease. A total of 996 participants were prospectively enrolled in a single Portuguese center. EAT volume was measured by Cardiac Computed Tomography and participants were distributed into 2 groups, above and below median EAT. SNPs were genotyped and linked to their respective pathophysiological axes. A multiplicative genetic risk score (mGRS) was constructed, representing the genetic burden of the studied SNPs. To evaluate the association between genetics and EAT, we compared both groups by global mGRS, mGRS by functional axes, and SNPs individually. Individuals above-median EAT were older, had a higher body mass index (BMI) and higher prevalence of hypertension, metabolic syndrome, diabetes, and dyslipidemia. They presented higher GRS, that remained an independent predictor of higher EAT volumes. The group with more EAT consistently presented higher polymorphic burden across numerous pathways. After adjustment, age, BMI, and mGRS of each functional axis emerged as independently related to higher EAT volumes. Amongst the 33 SNPs, MTHFR677 polymorphism emerged as the only significant and independent predictor of higher EAT volumes. Patients with higher polymorphism burden for atherosclerosis present higher EAT volumes. We present the first study in a Portuguese population, evaluating the genetic profile of EAT through GWAS and GRS, casting further insight into this complicated matter.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNSousa, João AdrianoMendonça, Maria IsabelSerrão, MarcoBorges, SofiaHenriques, EvaFreitas, SóniaTentem, MargaridaSantos, MarinaFreitas, PedroFerreira, AntónioGuerra, GraçaDrumond, AntónioPalma Reis, Roberto2021-11-03T05:02:52Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/127060eng1179-5468PURE: 34296806https://doi.org/10.1177/11795468211029244info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-10T16:03:19ZPortal AgregadorONG |
| dc.title.none.fl_str_mv |
Epicardial Adipose Tissue The Genetics Behind an Emerging Cardiovascular Risk Marker |
| title |
Epicardial Adipose Tissue |
| spellingShingle |
Epicardial Adipose Tissue Sousa, João Adriano atherosclerosis cardiovascular risk factors Epicardial adipose tissue genetic polymorphisms Genetic Risk Score Cardiology and Cardiovascular Medicine SDG 3 - Good Health and Well-being |
| title_short |
Epicardial Adipose Tissue |
| title_full |
Epicardial Adipose Tissue |
| title_fullStr |
Epicardial Adipose Tissue |
| title_full_unstemmed |
Epicardial Adipose Tissue |
| title_sort |
Epicardial Adipose Tissue |
| author |
Sousa, João Adriano |
| author_facet |
Sousa, João Adriano Mendonça, Maria Isabel Serrão, Marco Borges, Sofia Henriques, Eva Freitas, Sónia Tentem, Margarida Santos, Marina Freitas, Pedro Ferreira, António Guerra, Graça Drumond, António Palma Reis, Roberto |
| author_role |
author |
| author2 |
Mendonça, Maria Isabel Serrão, Marco Borges, Sofia Henriques, Eva Freitas, Sónia Tentem, Margarida Santos, Marina Freitas, Pedro Ferreira, António Guerra, Graça Drumond, António Palma Reis, Roberto |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Sousa, João Adriano Mendonça, Maria Isabel Serrão, Marco Borges, Sofia Henriques, Eva Freitas, Sónia Tentem, Margarida Santos, Marina Freitas, Pedro Ferreira, António Guerra, Graça Drumond, António Palma Reis, Roberto |
| dc.subject.por.fl_str_mv |
atherosclerosis cardiovascular risk factors Epicardial adipose tissue genetic polymorphisms Genetic Risk Score Cardiology and Cardiovascular Medicine SDG 3 - Good Health and Well-being |
| topic |
atherosclerosis cardiovascular risk factors Epicardial adipose tissue genetic polymorphisms Genetic Risk Score Cardiology and Cardiovascular Medicine SDG 3 - Good Health and Well-being |
| description |
Publisher Copyright: © The Author(s) 2021. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-11-03T05:02:52Z 2021 2021-01-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/127060 |
| url |
http://hdl.handle.net/10362/127060 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1179-5468 PURE: 34296806 https://doi.org/10.1177/11795468211029244 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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