Comparative study of the prevalence, clinical features, sensitisation profiles and risk factors for bronchial asthma between elderly and young adults in Cova da Beira
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Tipo de documento: | Dissertação |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.6/803 |
Resumo: | Background: Bronchial asthma is one of the most common allergic diseases worldwide. Very few studies have analysed whether the prevalence of asthma decreases with age. Therefore, the aim of the present study was to compare the prevalence, pattern of aeroallergen sensitization and clinical features of bronchial asthma between elderly and young adults. In addition, we also wanted to analyse possible risk factors for the development of asthma. Methods: This study followed a cross-sectional design. A standardised allergy and asthma questionnaire and skin prick tests (SPT) were carried out in all volunteers. The study population included two groups of individuals: elderly (aged 65 years and older) and young adults (aged between 18-35 years) from Beira Interior. The sample was selected by simple randomization, after calculating a confidence interval of 95% and an estimated error below 5%. Statistical analysis was carried out using Chi-square tests, Mann-Whitney U test, univariate regression analysis, binary logistic regression analysis and Odds Ratio. A p value less than 0.05 was considered statistically significant. All patients signed a written informed consent and the study was approved by the Regional Health Authority Ethics Committee. Results: A total sample of 1460 volunteers was included. Thus far, we have analyzed a total of 27.6% of elderly volunteers in the Health Care Centre (median age = 73 years; 41.5% males) and 14.1% of the young group (median age = 28 years; 44.2% males). A short questionnaire was applied by telephone to 11% of the total sample. We found significant differences in the prevalence of bronchial asthma between elderly and young adults (19.7% vs 29.4%, respectively; p=0.02; Chi-square test). In addition, the prevalence of atopic bronchial asthma was also significantly lower in elderly than in young adult patients (32.1% vs 57.1%, respectively; p=0.02, Chi-square test). Both groups were mostly sensitised to Dermatophagoides pteronyssinus and Dermatophagoides farinae. Significant differences were found in terms of sensitisation to grass pollens amongst elderly and young patients (11.8% vs 70.8%, respectively; p=0.0006, Chi-square test). The majority of the asthmatic patients were sensitised to more than one allergen. Finally, differences were observed in terms of risk factors for bronchial asthma between both groups, with gender as a significant risk factor in elderly patients and concomitant rhinitis in young patients. The presence of rhinitis augmented the risk of having asthma 3.2 times, in the group of young adults. |
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Comparative study of the prevalence, clinical features, sensitisation profiles and risk factors for bronchial asthma between elderly and young adults in Cova da BeiraAsma brônquicaAsma brônquica - IdososAsma brônquica - JovensAtopiaAsma brônquica - Testes cutâneosBackground: Bronchial asthma is one of the most common allergic diseases worldwide. Very few studies have analysed whether the prevalence of asthma decreases with age. Therefore, the aim of the present study was to compare the prevalence, pattern of aeroallergen sensitization and clinical features of bronchial asthma between elderly and young adults. In addition, we also wanted to analyse possible risk factors for the development of asthma. Methods: This study followed a cross-sectional design. A standardised allergy and asthma questionnaire and skin prick tests (SPT) were carried out in all volunteers. The study population included two groups of individuals: elderly (aged 65 years and older) and young adults (aged between 18-35 years) from Beira Interior. The sample was selected by simple randomization, after calculating a confidence interval of 95% and an estimated error below 5%. Statistical analysis was carried out using Chi-square tests, Mann-Whitney U test, univariate regression analysis, binary logistic regression analysis and Odds Ratio. A p value less than 0.05 was considered statistically significant. All patients signed a written informed consent and the study was approved by the Regional Health Authority Ethics Committee. Results: A total sample of 1460 volunteers was included. Thus far, we have analyzed a total of 27.6% of elderly volunteers in the Health Care Centre (median age = 73 years; 41.5% males) and 14.1% of the young group (median age = 28 years; 44.2% males). A short questionnaire was applied by telephone to 11% of the total sample. We found significant differences in the prevalence of bronchial asthma between elderly and young adults (19.7% vs 29.4%, respectively; p=0.02; Chi-square test). In addition, the prevalence of atopic bronchial asthma was also significantly lower in elderly than in young adult patients (32.1% vs 57.1%, respectively; p=0.02, Chi-square test). Both groups were mostly sensitised to Dermatophagoides pteronyssinus and Dermatophagoides farinae. Significant differences were found in terms of sensitisation to grass pollens amongst elderly and young patients (11.8% vs 70.8%, respectively; p=0.0006, Chi-square test). The majority of the asthmatic patients were sensitised to more than one allergen. Finally, differences were observed in terms of risk factors for bronchial asthma between both groups, with gender as a significant risk factor in elderly patients and concomitant rhinitis in young patients. The presence of rhinitis augmented the risk of having asthma 3.2 times, in the group of young adults.Introdução: A asma brônquica é uma das doenças mais comuns a nível mundial. Poucos estudos analisaram se a sua prevalência diminui com a idade. Assim sendo, o principal objectivo deste estudo foi comparar a prevalência, perfil de sensibilização, características clínicas e possíveis factores de risco para o desenvolvimento da asma em idosos e adultos jovens. Métodos: Estudo transversal que implicou a realização de questionário padrão sobre alergia e asma, bem como realização de testes cutâneos de alergia (TCA) a todos os voluntários. A população do estudo abrangeu dois grupos de indivíduos: idosos (com idade igual ou superior a 65 anos de idade) e adultos jovens (com idades compreendidas entre 18 e 35 anos) da Beira Interior. A amostra foi calculada através de randomização simples. A análise estatística consistiu na aplicação dos testes de Qui-quadrado, MannWhitney U, análise de regressão univariável, análise de regressão logística binária e Odds Ratio. Um valor de p abaixo de 0,05 foi considerado estatisticamente significativo. Todos os voluntários que participaram nesta investigação assinaram consentimento informado e o estudo foi aprovado pelo Comité de Ética da Autoridade Regional de Saúde. Resultados: A população do estudo consistiu em 1460 voluntários. Contudo, até ao momento, apenas analisámos um total de 27,6% de idosos no centro de saúde (idade média = 73 anos; 41,5% sexo masculino) e 14,1% do grupo de jovens (idade média 28; 44,2% sexo masculino). Foi aplicado um questionário simples por telefone a 11% do total da amostra. Encontrámos diferenças significativas relativas à prevalência da asma entre idosos e adultos jovens (19,7% vs 29,4%, respectivamente; p = 0,02; teste do Quiquadrado). Para além disto, a prevalência de asma brônquica atópica foi significativamente menor em idosos que em adultos jovens (32,1% vs 57,1%, respectivamente p=0,02). Ambos os grupos de doentes asmáticos demonstraram elevada sensibilização para Dermatophagoides pteronyssinus e Dermatophagoides farinae. Encontrámos diferenças significativas na sensibilização dos idosos e jovens para pólenes de ervas (11,8% vs 70,8%, respectivamente; p=0,0006, teste do Qui-quadrado). A maioria dos doentes asmáticos estava sensibilizada a mais de um alergéneo. Finalmente, foram constatadas diferenças relativamente aos factores de risco para desenvolvimento de asma nos diferentes grupos, sendo o sexo significativo no caso dos idosos e a concomitância de rinite nos jovens. A presença de rinite aumentou em 3,2 vezes a probabilidade de desenvolver asma nos adultos jovens.Universidade da Beira InteriorBarata, Luís Manuel TabordaFonseca, Ana Mafalda LoureirouBibliorumMoreira, Sónia Manuela Rodrigues2012-12-07T12:45:33Z2010-062010-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10400.6/803enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-15T09:36:10Zoai:ubibliorum.ubi.pt:10400.6/803Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:42:48.162467Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Comparative study of the prevalence, clinical features, sensitisation profiles and risk factors for bronchial asthma between elderly and young adults in Cova da Beira |
title |
Comparative study of the prevalence, clinical features, sensitisation profiles and risk factors for bronchial asthma between elderly and young adults in Cova da Beira |
spellingShingle |
Comparative study of the prevalence, clinical features, sensitisation profiles and risk factors for bronchial asthma between elderly and young adults in Cova da Beira Moreira, Sónia Manuela Rodrigues Asma brônquica Asma brônquica - Idosos Asma brônquica - Jovens Atopia Asma brônquica - Testes cutâneos |
title_short |
Comparative study of the prevalence, clinical features, sensitisation profiles and risk factors for bronchial asthma between elderly and young adults in Cova da Beira |
title_full |
Comparative study of the prevalence, clinical features, sensitisation profiles and risk factors for bronchial asthma between elderly and young adults in Cova da Beira |
title_fullStr |
Comparative study of the prevalence, clinical features, sensitisation profiles and risk factors for bronchial asthma between elderly and young adults in Cova da Beira |
title_full_unstemmed |
Comparative study of the prevalence, clinical features, sensitisation profiles and risk factors for bronchial asthma between elderly and young adults in Cova da Beira |
title_sort |
Comparative study of the prevalence, clinical features, sensitisation profiles and risk factors for bronchial asthma between elderly and young adults in Cova da Beira |
author |
Moreira, Sónia Manuela Rodrigues |
author_facet |
Moreira, Sónia Manuela Rodrigues |
author_role |
author |
dc.contributor.none.fl_str_mv |
Barata, Luís Manuel Taborda Fonseca, Ana Mafalda Loureiro uBibliorum |
dc.contributor.author.fl_str_mv |
Moreira, Sónia Manuela Rodrigues |
dc.subject.por.fl_str_mv |
Asma brônquica Asma brônquica - Idosos Asma brônquica - Jovens Atopia Asma brônquica - Testes cutâneos |
topic |
Asma brônquica Asma brônquica - Idosos Asma brônquica - Jovens Atopia Asma brônquica - Testes cutâneos |
description |
Background: Bronchial asthma is one of the most common allergic diseases worldwide. Very few studies have analysed whether the prevalence of asthma decreases with age. Therefore, the aim of the present study was to compare the prevalence, pattern of aeroallergen sensitization and clinical features of bronchial asthma between elderly and young adults. In addition, we also wanted to analyse possible risk factors for the development of asthma. Methods: This study followed a cross-sectional design. A standardised allergy and asthma questionnaire and skin prick tests (SPT) were carried out in all volunteers. The study population included two groups of individuals: elderly (aged 65 years and older) and young adults (aged between 18-35 years) from Beira Interior. The sample was selected by simple randomization, after calculating a confidence interval of 95% and an estimated error below 5%. Statistical analysis was carried out using Chi-square tests, Mann-Whitney U test, univariate regression analysis, binary logistic regression analysis and Odds Ratio. A p value less than 0.05 was considered statistically significant. All patients signed a written informed consent and the study was approved by the Regional Health Authority Ethics Committee. Results: A total sample of 1460 volunteers was included. Thus far, we have analyzed a total of 27.6% of elderly volunteers in the Health Care Centre (median age = 73 years; 41.5% males) and 14.1% of the young group (median age = 28 years; 44.2% males). A short questionnaire was applied by telephone to 11% of the total sample. We found significant differences in the prevalence of bronchial asthma between elderly and young adults (19.7% vs 29.4%, respectively; p=0.02; Chi-square test). In addition, the prevalence of atopic bronchial asthma was also significantly lower in elderly than in young adult patients (32.1% vs 57.1%, respectively; p=0.02, Chi-square test). Both groups were mostly sensitised to Dermatophagoides pteronyssinus and Dermatophagoides farinae. Significant differences were found in terms of sensitisation to grass pollens amongst elderly and young patients (11.8% vs 70.8%, respectively; p=0.0006, Chi-square test). The majority of the asthmatic patients were sensitised to more than one allergen. Finally, differences were observed in terms of risk factors for bronchial asthma between both groups, with gender as a significant risk factor in elderly patients and concomitant rhinitis in young patients. The presence of rhinitis augmented the risk of having asthma 3.2 times, in the group of young adults. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-06 2010-06-01T00:00:00Z 2012-12-07T12:45:33Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.6/803 |
url |
http://hdl.handle.net/10400.6/803 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade da Beira Interior |
publisher.none.fl_str_mv |
Universidade da Beira Interior |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799136328024064000 |