BorArAm - Catalytic Asymmetric Arylating Cyclizations: A New Route to Chiral Bicyclic Amines

Detalhes bibliográficos
Autor(a) principal: Mendes, Paulo J.
Data de Publicação: 2013
Outros Autores: Viana, H., Marques, C. S., Burke, Anthony J.
Tipo de documento: Artigo de conferência
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10174/8856
Resumo: Nowadays neurodegenerative diseases such as Alzheimer’s disease and Parkinson disease represent a worldwide health threat. Rasagiline is one well-known medication for the treatment of Parkinson's disease, but more and cheaper alternatives are required.1 For this reason, our group is currently investigating a new catalytic asymmetric arylating2 cyclization route - borylation-arylation-amination (BorArAm) (Scheme 1) giving useful potential lead compounds based on the rasagiline core structure for treating these diseases. Our results will be discussed in this communication.
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spelling BorArAm - Catalytic Asymmetric Arylating Cyclizations: A New Route to Chiral Bicyclic AminesAsymmetric CatalysisBicyclic AminesNowadays neurodegenerative diseases such as Alzheimer’s disease and Parkinson disease represent a worldwide health threat. Rasagiline is one well-known medication for the treatment of Parkinson's disease, but more and cheaper alternatives are required.1 For this reason, our group is currently investigating a new catalytic asymmetric arylating2 cyclization route - borylation-arylation-amination (BorArAm) (Scheme 1) giving useful potential lead compounds based on the rasagiline core structure for treating these diseases. Our results will be discussed in this communication.Sociedade Portuguesa de Química2013-10-14T11:43:01Z2013-10-142013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjecthttp://hdl.handle.net/10174/8856http://hdl.handle.net/10174/8856engH. Viana, C. S. Marques, Paulo J. Mendes, Anthony J. Burke, “BorArAm - Catalytic Asymmetric Arylating Cyclizations: A New Route to Chiral Bicyclic Amines”, 10º Encontro Nacional de Química Orgânica, 1º Simpósio Luso-Brasileiro de Química Orgânica, September 4-6, 2013, Lisbon, Portugal, Book of Abstracts PC103http://10enqo.eventos.chemistry.pt/?ver=sprogramnaonaosimQUIpjgm@uevora.ptndndnd307Mendes, Paulo J.Viana, H.Marques, C. S.Burke, Anthony J.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-08T03:59:52ZPortal AgregadorONG
dc.title.none.fl_str_mv BorArAm - Catalytic Asymmetric Arylating Cyclizations: A New Route to Chiral Bicyclic Amines
title BorArAm - Catalytic Asymmetric Arylating Cyclizations: A New Route to Chiral Bicyclic Amines
spellingShingle BorArAm - Catalytic Asymmetric Arylating Cyclizations: A New Route to Chiral Bicyclic Amines
Mendes, Paulo J.
Asymmetric Catalysis
Bicyclic Amines
title_short BorArAm - Catalytic Asymmetric Arylating Cyclizations: A New Route to Chiral Bicyclic Amines
title_full BorArAm - Catalytic Asymmetric Arylating Cyclizations: A New Route to Chiral Bicyclic Amines
title_fullStr BorArAm - Catalytic Asymmetric Arylating Cyclizations: A New Route to Chiral Bicyclic Amines
title_full_unstemmed BorArAm - Catalytic Asymmetric Arylating Cyclizations: A New Route to Chiral Bicyclic Amines
title_sort BorArAm - Catalytic Asymmetric Arylating Cyclizations: A New Route to Chiral Bicyclic Amines
author Mendes, Paulo J.
author_facet Mendes, Paulo J.
Viana, H.
Marques, C. S.
Burke, Anthony J.
author_role author
author2 Viana, H.
Marques, C. S.
Burke, Anthony J.
author2_role author
author
author
dc.contributor.author.fl_str_mv Mendes, Paulo J.
Viana, H.
Marques, C. S.
Burke, Anthony J.
dc.subject.por.fl_str_mv Asymmetric Catalysis
Bicyclic Amines
topic Asymmetric Catalysis
Bicyclic Amines
description Nowadays neurodegenerative diseases such as Alzheimer’s disease and Parkinson disease represent a worldwide health threat. Rasagiline is one well-known medication for the treatment of Parkinson's disease, but more and cheaper alternatives are required.1 For this reason, our group is currently investigating a new catalytic asymmetric arylating2 cyclization route - borylation-arylation-amination (BorArAm) (Scheme 1) giving useful potential lead compounds based on the rasagiline core structure for treating these diseases. Our results will be discussed in this communication.
publishDate 2013
dc.date.none.fl_str_mv 2013-10-14T11:43:01Z
2013-10-14
2013-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/conferenceObject
format conferenceObject
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10174/8856
http://hdl.handle.net/10174/8856
url http://hdl.handle.net/10174/8856
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv H. Viana, C. S. Marques, Paulo J. Mendes, Anthony J. Burke, “BorArAm - Catalytic Asymmetric Arylating Cyclizations: A New Route to Chiral Bicyclic Amines”, 10º Encontro Nacional de Química Orgânica, 1º Simpósio Luso-Brasileiro de Química Orgânica, September 4-6, 2013, Lisbon, Portugal, Book of Abstracts PC103
http://10enqo.eventos.chemistry.pt/?ver=sprogram
nao
nao
sim
QUI
pjgm@uevora.pt
nd
nd
nd
307
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dc.publisher.none.fl_str_mv Sociedade Portuguesa de Química
publisher.none.fl_str_mv Sociedade Portuguesa de Química
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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