Comprehensive multidimensional liquid chromatography for advancing environmental and natural products research
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/26385 |
Resumo: | Chromatography is the separation method of choice in most laboratories worldwide. Nonetheless, the increasing need to decode complex samples has created a demand for better separation skills. The addition of extra separation dimensions to a conventional liquid chromatography system was one of the ways to answer to this demand. Although very common in proteomics and polymer research, the use of Multidimensional Liquid Chromatography (MDLC) coupled to high-resolution detectors for separation and analysis of environmental and natural products samples has yet to receive the deserved attention. This article presents a critical review on the most prominent of these comprehensive MDLC methods for targeted and untargeted analysis of complex environmental and natural products samples. This article also discusses the practical aspects of applying peak capacity and orthogonality concepts in MDLC analysis of complex matrices. It also addresses the limitations and challenges ahead for advancing environmental and natural products research using comprehensive MDLC. |
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Comprehensive multidimensional liquid chromatography for advancing environmental and natural products researchMultidimensional liquid chromatography2D-LCLC×LCTargeted and untargeted analysisComplex samples profilingSeparation mechanismsNatural organic matterWastewatersTraditional Chinese medicinesHigh resolution detectorsChromatography is the separation method of choice in most laboratories worldwide. Nonetheless, the increasing need to decode complex samples has created a demand for better separation skills. The addition of extra separation dimensions to a conventional liquid chromatography system was one of the ways to answer to this demand. Although very common in proteomics and polymer research, the use of Multidimensional Liquid Chromatography (MDLC) coupled to high-resolution detectors for separation and analysis of environmental and natural products samples has yet to receive the deserved attention. This article presents a critical review on the most prominent of these comprehensive MDLC methods for targeted and untargeted analysis of complex environmental and natural products samples. This article also discusses the practical aspects of applying peak capacity and orthogonality concepts in MDLC analysis of complex matrices. It also addresses the limitations and challenges ahead for advancing environmental and natural products research using comprehensive MDLC.Elsevier2019-072019-07-01T00:00:00Z2020-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/26385eng0165-993610.1016/j.trac.2019.05.016Brandão, Pedro F.Duarte, Armando C.Duarte, Regina M. B. O.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:51:08Zoai:ria.ua.pt:10773/26385Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:59:24.372291Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Comprehensive multidimensional liquid chromatography for advancing environmental and natural products research |
title |
Comprehensive multidimensional liquid chromatography for advancing environmental and natural products research |
spellingShingle |
Comprehensive multidimensional liquid chromatography for advancing environmental and natural products research Brandão, Pedro F. Multidimensional liquid chromatography 2D-LC LC×LC Targeted and untargeted analysis Complex samples profiling Separation mechanisms Natural organic matter Wastewaters Traditional Chinese medicines High resolution detectors |
title_short |
Comprehensive multidimensional liquid chromatography for advancing environmental and natural products research |
title_full |
Comprehensive multidimensional liquid chromatography for advancing environmental and natural products research |
title_fullStr |
Comprehensive multidimensional liquid chromatography for advancing environmental and natural products research |
title_full_unstemmed |
Comprehensive multidimensional liquid chromatography for advancing environmental and natural products research |
title_sort |
Comprehensive multidimensional liquid chromatography for advancing environmental and natural products research |
author |
Brandão, Pedro F. |
author_facet |
Brandão, Pedro F. Duarte, Armando C. Duarte, Regina M. B. O. |
author_role |
author |
author2 |
Duarte, Armando C. Duarte, Regina M. B. O. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Brandão, Pedro F. Duarte, Armando C. Duarte, Regina M. B. O. |
dc.subject.por.fl_str_mv |
Multidimensional liquid chromatography 2D-LC LC×LC Targeted and untargeted analysis Complex samples profiling Separation mechanisms Natural organic matter Wastewaters Traditional Chinese medicines High resolution detectors |
topic |
Multidimensional liquid chromatography 2D-LC LC×LC Targeted and untargeted analysis Complex samples profiling Separation mechanisms Natural organic matter Wastewaters Traditional Chinese medicines High resolution detectors |
description |
Chromatography is the separation method of choice in most laboratories worldwide. Nonetheless, the increasing need to decode complex samples has created a demand for better separation skills. The addition of extra separation dimensions to a conventional liquid chromatography system was one of the ways to answer to this demand. Although very common in proteomics and polymer research, the use of Multidimensional Liquid Chromatography (MDLC) coupled to high-resolution detectors for separation and analysis of environmental and natural products samples has yet to receive the deserved attention. This article presents a critical review on the most prominent of these comprehensive MDLC methods for targeted and untargeted analysis of complex environmental and natural products samples. This article also discusses the practical aspects of applying peak capacity and orthogonality concepts in MDLC analysis of complex matrices. It also addresses the limitations and challenges ahead for advancing environmental and natural products research using comprehensive MDLC. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-07 2019-07-01T00:00:00Z 2020-07-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/26385 |
url |
http://hdl.handle.net/10773/26385 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0165-9936 10.1016/j.trac.2019.05.016 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137648356360192 |