Electrochemical and spectrophotometric characterisation of protein kinase inhibitor and anticancer drug danusertib

Detalhes bibliográficos
Autor(a) principal: Popa, Oana M.
Data de Publicação: 2013
Outros Autores: Diculescu, Victor C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/27388
https://doi.org/10.1016/j.electacta.2013.09.017
Resumo: The electrochemical oxidation mechanism of the anti-cancer drug and kinases inhibitor danusertib was studied by cyclic, differential pulse, square wave voltammetry and a glassy carbon electrode. Danusertib undergoes oxidation in a cascade mechanism and depending on the pH of the supporting electrolyte several oxidation peaks were observed. The number of electrons and protons involved in each oxidation step as well as the pKa ∼ 10.0 were determined. The analytical determination of danusertib was carried out in pH = 7.0 by square wave voltammetry with LOD = 27.4 nM and UV–VIS spectrophotometry with LOD = 0.5 μM. Different electroactive centres of danusertib were identified through comparative studies with similar compounds such as imatinib and piperazine, and an oxidation mechanism of danusertib proposed.
id RCAP_353e4d59b0dcf5044c072a2ca79de08a
oai_identifier_str oai:estudogeral.uc.pt:10316/27388
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str
spelling Electrochemical and spectrophotometric characterisation of protein kinase inhibitor and anticancer drug danusertibDanusertibKinase inhibitorGlassy carbonRedox mechanismAnalytical determinationThe electrochemical oxidation mechanism of the anti-cancer drug and kinases inhibitor danusertib was studied by cyclic, differential pulse, square wave voltammetry and a glassy carbon electrode. Danusertib undergoes oxidation in a cascade mechanism and depending on the pH of the supporting electrolyte several oxidation peaks were observed. The number of electrons and protons involved in each oxidation step as well as the pKa ∼ 10.0 were determined. The analytical determination of danusertib was carried out in pH = 7.0 by square wave voltammetry with LOD = 27.4 nM and UV–VIS spectrophotometry with LOD = 0.5 μM. Different electroactive centres of danusertib were identified through comparative studies with similar compounds such as imatinib and piperazine, and an oxidation mechanism of danusertib proposed.Elsevier2013-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/27388http://hdl.handle.net/10316/27388https://doi.org/10.1016/j.electacta.2013.09.017engPOPA, Oana M.; DICULESCU, Victor C. - Electrochemical and spectrophotometric characterisation of protein kinase inhibitor and anticancer drug danusertib. "Electrochimica Acta". ISSN 0013-4686. Vol. 112 (2013) p. 486-4920013-4686http://www.sciencedirect.com/science/article/pii/S0013468613017398Popa, Oana M.Diculescu, Victor C.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-02-20T11:15:10ZPortal AgregadorONG
dc.title.none.fl_str_mv Electrochemical and spectrophotometric characterisation of protein kinase inhibitor and anticancer drug danusertib
title Electrochemical and spectrophotometric characterisation of protein kinase inhibitor and anticancer drug danusertib
spellingShingle Electrochemical and spectrophotometric characterisation of protein kinase inhibitor and anticancer drug danusertib
Popa, Oana M.
Danusertib
Kinase inhibitor
Glassy carbon
Redox mechanism
Analytical determination
title_short Electrochemical and spectrophotometric characterisation of protein kinase inhibitor and anticancer drug danusertib
title_full Electrochemical and spectrophotometric characterisation of protein kinase inhibitor and anticancer drug danusertib
title_fullStr Electrochemical and spectrophotometric characterisation of protein kinase inhibitor and anticancer drug danusertib
title_full_unstemmed Electrochemical and spectrophotometric characterisation of protein kinase inhibitor and anticancer drug danusertib
title_sort Electrochemical and spectrophotometric characterisation of protein kinase inhibitor and anticancer drug danusertib
author Popa, Oana M.
author_facet Popa, Oana M.
Diculescu, Victor C.
author_role author
author2 Diculescu, Victor C.
author2_role author
dc.contributor.author.fl_str_mv Popa, Oana M.
Diculescu, Victor C.
dc.subject.por.fl_str_mv Danusertib
Kinase inhibitor
Glassy carbon
Redox mechanism
Analytical determination
topic Danusertib
Kinase inhibitor
Glassy carbon
Redox mechanism
Analytical determination
description The electrochemical oxidation mechanism of the anti-cancer drug and kinases inhibitor danusertib was studied by cyclic, differential pulse, square wave voltammetry and a glassy carbon electrode. Danusertib undergoes oxidation in a cascade mechanism and depending on the pH of the supporting electrolyte several oxidation peaks were observed. The number of electrons and protons involved in each oxidation step as well as the pKa ∼ 10.0 were determined. The analytical determination of danusertib was carried out in pH = 7.0 by square wave voltammetry with LOD = 27.4 nM and UV–VIS spectrophotometry with LOD = 0.5 μM. Different electroactive centres of danusertib were identified through comparative studies with similar compounds such as imatinib and piperazine, and an oxidation mechanism of danusertib proposed.
publishDate 2013
dc.date.none.fl_str_mv 2013-12-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/27388
http://hdl.handle.net/10316/27388
https://doi.org/10.1016/j.electacta.2013.09.017
url http://hdl.handle.net/10316/27388
https://doi.org/10.1016/j.electacta.2013.09.017
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv POPA, Oana M.; DICULESCU, Victor C. - Electrochemical and spectrophotometric characterisation of protein kinase inhibitor and anticancer drug danusertib. "Electrochimica Acta". ISSN 0013-4686. Vol. 112 (2013) p. 486-492
0013-4686
http://www.sciencedirect.com/science/article/pii/S0013468613017398
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1777302672513171456

Registros relacionados