Nanocellulose-based antifungal nanocomposites against the polymorphic fungus Candida albicans
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/37412 |
Resumo: | The design of functional materials capable of fighting fungal infections is of paramount importance given the intricate problem of multidrug-resistant pathogenic fungi. Herein, nanocomposites consisting of cross-linked poly([2-(methacryloyloxy)ethyl]trimethylammonium chloride) (PMETAC) and bacterial nanocellulose (BNC) were prepared, characterized and tested towards the polymorphic fungus Candida albicans. The BNC three-dimensional network enabled the in-situ polymerization of the non-toxic and bioactive quaternary-ammonium monomer, which originated transparent nanocomposites containing 10 and 40 wt.% of cross-linked PMETAC. Furthermore, the nanocomposites exhibit UV-A and UV-B blocking properties, high water-uptake capacity, thermal stability up to 200 °C, good viscoelastic (storage modulus > 1.7 GPa) and mechanical (Young's modulus ≥2.4 GPa) properties and are non-cytotoxic to human keratinocytes (HaCaT cells). The fungal inactivation reached a 4.4 ± 0.14-log CFU reduction for the nanocomposite containing only 10 wt.% of cross-linked PMETAC. Hence, these bioactive and non-cytotoxic materials can constitute potentially effective systems for the treatment of C. albicans infections. |
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Nanocellulose-based antifungal nanocomposites against the polymorphic fungus Candida albicansAntifungal activityBacterial nanocelluloseCandida albicansCutaneous treatmentIn-situpolymerizationPoly([2-(methacryloyloxy)ethyl]trimethylammonium chloride)The design of functional materials capable of fighting fungal infections is of paramount importance given the intricate problem of multidrug-resistant pathogenic fungi. Herein, nanocomposites consisting of cross-linked poly([2-(methacryloyloxy)ethyl]trimethylammonium chloride) (PMETAC) and bacterial nanocellulose (BNC) were prepared, characterized and tested towards the polymorphic fungus Candida albicans. The BNC three-dimensional network enabled the in-situ polymerization of the non-toxic and bioactive quaternary-ammonium monomer, which originated transparent nanocomposites containing 10 and 40 wt.% of cross-linked PMETAC. Furthermore, the nanocomposites exhibit UV-A and UV-B blocking properties, high water-uptake capacity, thermal stability up to 200 °C, good viscoelastic (storage modulus > 1.7 GPa) and mechanical (Young's modulus ≥2.4 GPa) properties and are non-cytotoxic to human keratinocytes (HaCaT cells). The fungal inactivation reached a 4.4 ± 0.14-log CFU reduction for the nanocomposite containing only 10 wt.% of cross-linked PMETAC. Hence, these bioactive and non-cytotoxic materials can constitute potentially effective systems for the treatment of C. albicans infections.Elsevier2023-04-27T13:28:57Z2019-08-01T00:00:00Z2019-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/37412eng0144-861710.1016/j.carbpol.2019.04.046Vilela, CarlaOliveira, HelenaAlmeida, AdelaideSilvestre, Armando J. D.Freire, Carmen S. R.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:12:12Zoai:ria.ua.pt:10773/37412Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:08:00.994209Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Nanocellulose-based antifungal nanocomposites against the polymorphic fungus Candida albicans |
title |
Nanocellulose-based antifungal nanocomposites against the polymorphic fungus Candida albicans |
spellingShingle |
Nanocellulose-based antifungal nanocomposites against the polymorphic fungus Candida albicans Vilela, Carla Antifungal activity Bacterial nanocellulose Candida albicans Cutaneous treatment In-situpolymerization Poly([2-(methacryloyloxy)ethyl]trimethylammonium chloride) |
title_short |
Nanocellulose-based antifungal nanocomposites against the polymorphic fungus Candida albicans |
title_full |
Nanocellulose-based antifungal nanocomposites against the polymorphic fungus Candida albicans |
title_fullStr |
Nanocellulose-based antifungal nanocomposites against the polymorphic fungus Candida albicans |
title_full_unstemmed |
Nanocellulose-based antifungal nanocomposites against the polymorphic fungus Candida albicans |
title_sort |
Nanocellulose-based antifungal nanocomposites against the polymorphic fungus Candida albicans |
author |
Vilela, Carla |
author_facet |
Vilela, Carla Oliveira, Helena Almeida, Adelaide Silvestre, Armando J. D. Freire, Carmen S. R. |
author_role |
author |
author2 |
Oliveira, Helena Almeida, Adelaide Silvestre, Armando J. D. Freire, Carmen S. R. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Vilela, Carla Oliveira, Helena Almeida, Adelaide Silvestre, Armando J. D. Freire, Carmen S. R. |
dc.subject.por.fl_str_mv |
Antifungal activity Bacterial nanocellulose Candida albicans Cutaneous treatment In-situpolymerization Poly([2-(methacryloyloxy)ethyl]trimethylammonium chloride) |
topic |
Antifungal activity Bacterial nanocellulose Candida albicans Cutaneous treatment In-situpolymerization Poly([2-(methacryloyloxy)ethyl]trimethylammonium chloride) |
description |
The design of functional materials capable of fighting fungal infections is of paramount importance given the intricate problem of multidrug-resistant pathogenic fungi. Herein, nanocomposites consisting of cross-linked poly([2-(methacryloyloxy)ethyl]trimethylammonium chloride) (PMETAC) and bacterial nanocellulose (BNC) were prepared, characterized and tested towards the polymorphic fungus Candida albicans. The BNC three-dimensional network enabled the in-situ polymerization of the non-toxic and bioactive quaternary-ammonium monomer, which originated transparent nanocomposites containing 10 and 40 wt.% of cross-linked PMETAC. Furthermore, the nanocomposites exhibit UV-A and UV-B blocking properties, high water-uptake capacity, thermal stability up to 200 °C, good viscoelastic (storage modulus > 1.7 GPa) and mechanical (Young's modulus ≥2.4 GPa) properties and are non-cytotoxic to human keratinocytes (HaCaT cells). The fungal inactivation reached a 4.4 ± 0.14-log CFU reduction for the nanocomposite containing only 10 wt.% of cross-linked PMETAC. Hence, these bioactive and non-cytotoxic materials can constitute potentially effective systems for the treatment of C. albicans infections. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-08-01T00:00:00Z 2019-08-01 2023-04-27T13:28:57Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/37412 |
url |
http://hdl.handle.net/10773/37412 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0144-8617 10.1016/j.carbpol.2019.04.046 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799137733904433152 |