Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patients
Main Author: | |
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Publication Date: | 2013 |
Other Authors: | , , , , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Download full: | http://hdl.handle.net/1822/24906 |
Summary: | Gastric cancer is a leading cause of cancer-related mortality, and the presence of lymph node metastasis an important prognostic factor. Downregulation of RKIP has been associated with tumor progression and metastasis in several types of neoplasms, being currently categorized as a metastasis suppressor gene. Our aim was to determine the expression levels of RKIP in gastric tissues and to evaluate its impact in the clinical outcome of gastric carcinoma patients. RKIP expression levels were studied by immunohistochemistry in a series of gastric tissues. Overall, we analysed 222 non-neoplastic gastric tissues, 152 primary tumors and 42 lymph node metastasis samples. We observed that RKIP was highly expressed in ~83% of non-neoplastic tissues (including normal tissue and metaplasia), was lost in ~56% of primary tumors and in ~90% of lymph node metastasis samples. Loss of RKIP expression was significantly associated with several markers of poor clinical outcome, including the presence of lymph node metastasis. Furthermore, the absence of RKIP protein constitutes an independent prognostic marker for these patients. In conclusion, RKIP expression is significantly lost during gastric carcinoma progression being almost absent in lymph node metastasis samples. Of note, we showed that the absence of RKIP expression is associated with poor outcome features of gastric cancer patients, this being also an independent prognostic marker. |
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Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patientsRKIPgastric carcinomasprognosisScience & TechnologyGastric cancer is a leading cause of cancer-related mortality, and the presence of lymph node metastasis an important prognostic factor. Downregulation of RKIP has been associated with tumor progression and metastasis in several types of neoplasms, being currently categorized as a metastasis suppressor gene. Our aim was to determine the expression levels of RKIP in gastric tissues and to evaluate its impact in the clinical outcome of gastric carcinoma patients. RKIP expression levels were studied by immunohistochemistry in a series of gastric tissues. Overall, we analysed 222 non-neoplastic gastric tissues, 152 primary tumors and 42 lymph node metastasis samples. We observed that RKIP was highly expressed in ~83% of non-neoplastic tissues (including normal tissue and metaplasia), was lost in ~56% of primary tumors and in ~90% of lymph node metastasis samples. Loss of RKIP expression was significantly associated with several markers of poor clinical outcome, including the presence of lymph node metastasis. Furthermore, the absence of RKIP protein constitutes an independent prognostic marker for these patients. In conclusion, RKIP expression is significantly lost during gastric carcinoma progression being almost absent in lymph node metastasis samples. Of note, we showed that the absence of RKIP expression is associated with poor outcome features of gastric cancer patients, this being also an independent prognostic marker.Olga Martinho was recipient of a PhD fellowship (SFRH/BD/36463/2007) from Fundacao para a Ciencia e Tecnologia (FCT), Portugal.Spandidos PublicationsUniversidade do MinhoMartinho, OlgaLongatto Filho, AdhemarReis, R. M.Simões, KleberJacob, Carlos EduardoZilberstein, BrunoBresciani, CláudioRodrigues, Joaquim GamaCecconello, IvanAlves, Venâncio Avancini Ferreira20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/24906eng1021-335X10.3892/or.2012.217923232914http://www.spandidos-publications.com/or/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:25:26Zoai:repositorium.sdum.uminho.pt:1822/24906Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:19:39.995326Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patients |
title |
Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patients |
spellingShingle |
Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patients Martinho, Olga RKIP gastric carcinomas prognosis Science & Technology |
title_short |
Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patients |
title_full |
Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patients |
title_fullStr |
Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patients |
title_full_unstemmed |
Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patients |
title_sort |
Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patients |
author |
Martinho, Olga |
author_facet |
Martinho, Olga Longatto Filho, Adhemar Reis, R. M. Simões, Kleber Jacob, Carlos Eduardo Zilberstein, Bruno Bresciani, Cláudio Rodrigues, Joaquim Gama Cecconello, Ivan Alves, Venâncio Avancini Ferreira |
author_role |
author |
author2 |
Longatto Filho, Adhemar Reis, R. M. Simões, Kleber Jacob, Carlos Eduardo Zilberstein, Bruno Bresciani, Cláudio Rodrigues, Joaquim Gama Cecconello, Ivan Alves, Venâncio Avancini Ferreira |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Martinho, Olga Longatto Filho, Adhemar Reis, R. M. Simões, Kleber Jacob, Carlos Eduardo Zilberstein, Bruno Bresciani, Cláudio Rodrigues, Joaquim Gama Cecconello, Ivan Alves, Venâncio Avancini Ferreira |
dc.subject.por.fl_str_mv |
RKIP gastric carcinomas prognosis Science & Technology |
topic |
RKIP gastric carcinomas prognosis Science & Technology |
description |
Gastric cancer is a leading cause of cancer-related mortality, and the presence of lymph node metastasis an important prognostic factor. Downregulation of RKIP has been associated with tumor progression and metastasis in several types of neoplasms, being currently categorized as a metastasis suppressor gene. Our aim was to determine the expression levels of RKIP in gastric tissues and to evaluate its impact in the clinical outcome of gastric carcinoma patients. RKIP expression levels were studied by immunohistochemistry in a series of gastric tissues. Overall, we analysed 222 non-neoplastic gastric tissues, 152 primary tumors and 42 lymph node metastasis samples. We observed that RKIP was highly expressed in ~83% of non-neoplastic tissues (including normal tissue and metaplasia), was lost in ~56% of primary tumors and in ~90% of lymph node metastasis samples. Loss of RKIP expression was significantly associated with several markers of poor clinical outcome, including the presence of lymph node metastasis. Furthermore, the absence of RKIP protein constitutes an independent prognostic marker for these patients. In conclusion, RKIP expression is significantly lost during gastric carcinoma progression being almost absent in lymph node metastasis samples. Of note, we showed that the absence of RKIP expression is associated with poor outcome features of gastric cancer patients, this being also an independent prognostic marker. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013 2013-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/24906 |
url |
http://hdl.handle.net/1822/24906 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1021-335X 10.3892/or.2012.2179 23232914 http://www.spandidos-publications.com/or/ |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Spandidos Publications |
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Spandidos Publications |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132657122017280 |