Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patients

Bibliographic Details
Main Author: Martinho, Olga
Publication Date: 2013
Other Authors: Longatto Filho, Adhemar, Reis, R. M., Simões, Kleber, Jacob, Carlos Eduardo, Zilberstein, Bruno, Bresciani, Cláudio, Rodrigues, Joaquim Gama, Cecconello, Ivan, Alves, Venâncio Avancini Ferreira
Format: Article
Language: eng
Source: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Download full: http://hdl.handle.net/1822/24906
Summary: Gastric cancer is a leading cause of cancer-related mortality, and the presence of lymph node metastasis an important prognostic factor. Downregulation of RKIP has been associated with tumor progression and metastasis in several types of neoplasms, being currently categorized as a metastasis suppressor gene. Our aim was to determine the expression levels of RKIP in gastric tissues and to evaluate its impact in the clinical outcome of gastric carcinoma patients. RKIP expression levels were studied by immunohistochemistry in a series of gastric tissues. Overall, we analysed 222 non-neoplastic gastric tissues, 152 primary tumors and 42 lymph node metastasis samples. We observed that RKIP was highly expressed in ~83% of non-neoplastic tissues (including normal tissue and metaplasia), was lost in ~56% of primary tumors and in ~90% of lymph node metastasis samples. Loss of RKIP expression was significantly associated with several markers of poor clinical outcome, including the presence of lymph node metastasis. Furthermore, the absence of RKIP protein constitutes an independent prognostic marker for these patients. In conclusion, RKIP expression is significantly lost during gastric carcinoma progression being almost absent in lymph node metastasis samples. Of note, we showed that the absence of RKIP expression is associated with poor outcome features of gastric cancer patients, this being also an independent prognostic marker.
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spelling Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patientsRKIPgastric carcinomasprognosisScience & TechnologyGastric cancer is a leading cause of cancer-related mortality, and the presence of lymph node metastasis an important prognostic factor. Downregulation of RKIP has been associated with tumor progression and metastasis in several types of neoplasms, being currently categorized as a metastasis suppressor gene. Our aim was to determine the expression levels of RKIP in gastric tissues and to evaluate its impact in the clinical outcome of gastric carcinoma patients. RKIP expression levels were studied by immunohistochemistry in a series of gastric tissues. Overall, we analysed 222 non-neoplastic gastric tissues, 152 primary tumors and 42 lymph node metastasis samples. We observed that RKIP was highly expressed in ~83% of non-neoplastic tissues (including normal tissue and metaplasia), was lost in ~56% of primary tumors and in ~90% of lymph node metastasis samples. Loss of RKIP expression was significantly associated with several markers of poor clinical outcome, including the presence of lymph node metastasis. Furthermore, the absence of RKIP protein constitutes an independent prognostic marker for these patients. In conclusion, RKIP expression is significantly lost during gastric carcinoma progression being almost absent in lymph node metastasis samples. Of note, we showed that the absence of RKIP expression is associated with poor outcome features of gastric cancer patients, this being also an independent prognostic marker.Olga Martinho was recipient of a PhD fellowship (SFRH/BD/36463/2007) from Fundacao para a Ciencia e Tecnologia (FCT), Portugal.Spandidos PublicationsUniversidade do MinhoMartinho, OlgaLongatto Filho, AdhemarReis, R. M.Simões, KleberJacob, Carlos EduardoZilberstein, BrunoBresciani, CláudioRodrigues, Joaquim GamaCecconello, IvanAlves, Venâncio Avancini Ferreira20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/24906eng1021-335X10.3892/or.2012.217923232914http://www.spandidos-publications.com/or/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:25:26Zoai:repositorium.sdum.uminho.pt:1822/24906Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:19:39.995326Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patients
title Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patients
spellingShingle Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patients
Martinho, Olga
RKIP
gastric carcinomas
prognosis
Science & Technology
title_short Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patients
title_full Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patients
title_fullStr Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patients
title_full_unstemmed Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patients
title_sort Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patients
author Martinho, Olga
author_facet Martinho, Olga
Longatto Filho, Adhemar
Reis, R. M.
Simões, Kleber
Jacob, Carlos Eduardo
Zilberstein, Bruno
Bresciani, Cláudio
Rodrigues, Joaquim Gama
Cecconello, Ivan
Alves, Venâncio Avancini Ferreira
author_role author
author2 Longatto Filho, Adhemar
Reis, R. M.
Simões, Kleber
Jacob, Carlos Eduardo
Zilberstein, Bruno
Bresciani, Cláudio
Rodrigues, Joaquim Gama
Cecconello, Ivan
Alves, Venâncio Avancini Ferreira
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Martinho, Olga
Longatto Filho, Adhemar
Reis, R. M.
Simões, Kleber
Jacob, Carlos Eduardo
Zilberstein, Bruno
Bresciani, Cláudio
Rodrigues, Joaquim Gama
Cecconello, Ivan
Alves, Venâncio Avancini Ferreira
dc.subject.por.fl_str_mv RKIP
gastric carcinomas
prognosis
Science & Technology
topic RKIP
gastric carcinomas
prognosis
Science & Technology
description Gastric cancer is a leading cause of cancer-related mortality, and the presence of lymph node metastasis an important prognostic factor. Downregulation of RKIP has been associated with tumor progression and metastasis in several types of neoplasms, being currently categorized as a metastasis suppressor gene. Our aim was to determine the expression levels of RKIP in gastric tissues and to evaluate its impact in the clinical outcome of gastric carcinoma patients. RKIP expression levels were studied by immunohistochemistry in a series of gastric tissues. Overall, we analysed 222 non-neoplastic gastric tissues, 152 primary tumors and 42 lymph node metastasis samples. We observed that RKIP was highly expressed in ~83% of non-neoplastic tissues (including normal tissue and metaplasia), was lost in ~56% of primary tumors and in ~90% of lymph node metastasis samples. Loss of RKIP expression was significantly associated with several markers of poor clinical outcome, including the presence of lymph node metastasis. Furthermore, the absence of RKIP protein constitutes an independent prognostic marker for these patients. In conclusion, RKIP expression is significantly lost during gastric carcinoma progression being almost absent in lymph node metastasis samples. Of note, we showed that the absence of RKIP expression is associated with poor outcome features of gastric cancer patients, this being also an independent prognostic marker.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/24906
url http://hdl.handle.net/1822/24906
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1021-335X
10.3892/or.2012.2179
23232914
http://www.spandidos-publications.com/or/
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eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Spandidos Publications
publisher.none.fl_str_mv Spandidos Publications
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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