The Dark Side of the Light: Mechanisms of Photocarcinogenesis

Detalhes bibliográficos
Autor(a) principal: Valejo Coelho, M
Data de Publicação: 2016
Outros Autores: Matos, T, Apetato, M
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.17/2717
Resumo: Ultraviolet radiation (UVR) can have a beneficial biologic impact on skin, but it is also the most significant environmental risk factor for skin cancer development. Photocarcinogenesis comprises a complex interplay between the carcinogenic UVR, skin, and the immune system. UVB is absorbed by the superficial skin layers and is mainly responsible for direct DNA damage, which, if unrepaired, can lead to mutations in key cancer genes. UVA is less carcinogenic, penetrates deeper in the dermis, and mainly causes indirect oxidative damage to cellular DNA, proteins, and lipids, via photosensitized reactions. UVR not only induces mutagenesis, altering proliferation and differentiation of skin cells, but also has several immunosuppressive effects that compromise tumor immunosurveillance by impairing antigen presentation, inducing suppressive cells, and modulating the cytokine environment. This review focuses upon molecular and cellular effects of UVR, regarding its role in skin cancer development.
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spelling The Dark Side of the Light: Mechanisms of PhotocarcinogenesisAntigen PresentationCarcinogenesisCytokinesDNA DamageHumansImmune ToleranceMutagenesisOxidative StressSkinSkin DiseasesSkin NeoplasmsT-Lymphocytes, RegulatoryUltraviolet TherapyNeoplasms, Radiation-InducedCHLC DERUltraviolet radiation (UVR) can have a beneficial biologic impact on skin, but it is also the most significant environmental risk factor for skin cancer development. Photocarcinogenesis comprises a complex interplay between the carcinogenic UVR, skin, and the immune system. UVB is absorbed by the superficial skin layers and is mainly responsible for direct DNA damage, which, if unrepaired, can lead to mutations in key cancer genes. UVA is less carcinogenic, penetrates deeper in the dermis, and mainly causes indirect oxidative damage to cellular DNA, proteins, and lipids, via photosensitized reactions. UVR not only induces mutagenesis, altering proliferation and differentiation of skin cells, but also has several immunosuppressive effects that compromise tumor immunosurveillance by impairing antigen presentation, inducing suppressive cells, and modulating the cytokine environment. This review focuses upon molecular and cellular effects of UVR, regarding its role in skin cancer development.ElsevierRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEValejo Coelho, MMatos, TApetato, M2017-06-30T15:16:23Z20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/2717engClin Dermatol. 2016 Sep-Oct;34(5):563-7010.1016/j.clindermatol.2016.05.022info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:39:18Zoai:repositorio.chlc.min-saude.pt:10400.17/2717Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:20:03.230907Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The Dark Side of the Light: Mechanisms of Photocarcinogenesis
title The Dark Side of the Light: Mechanisms of Photocarcinogenesis
spellingShingle The Dark Side of the Light: Mechanisms of Photocarcinogenesis
Valejo Coelho, M
Antigen Presentation
Carcinogenesis
Cytokines
DNA Damage
Humans
Immune Tolerance
Mutagenesis
Oxidative Stress
Skin
Skin Diseases
Skin Neoplasms
T-Lymphocytes, Regulatory
Ultraviolet Therapy
Neoplasms, Radiation-Induced
CHLC DER
title_short The Dark Side of the Light: Mechanisms of Photocarcinogenesis
title_full The Dark Side of the Light: Mechanisms of Photocarcinogenesis
title_fullStr The Dark Side of the Light: Mechanisms of Photocarcinogenesis
title_full_unstemmed The Dark Side of the Light: Mechanisms of Photocarcinogenesis
title_sort The Dark Side of the Light: Mechanisms of Photocarcinogenesis
author Valejo Coelho, M
author_facet Valejo Coelho, M
Matos, T
Apetato, M
author_role author
author2 Matos, T
Apetato, M
author2_role author
author
dc.contributor.none.fl_str_mv Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE
dc.contributor.author.fl_str_mv Valejo Coelho, M
Matos, T
Apetato, M
dc.subject.por.fl_str_mv Antigen Presentation
Carcinogenesis
Cytokines
DNA Damage
Humans
Immune Tolerance
Mutagenesis
Oxidative Stress
Skin
Skin Diseases
Skin Neoplasms
T-Lymphocytes, Regulatory
Ultraviolet Therapy
Neoplasms, Radiation-Induced
CHLC DER
topic Antigen Presentation
Carcinogenesis
Cytokines
DNA Damage
Humans
Immune Tolerance
Mutagenesis
Oxidative Stress
Skin
Skin Diseases
Skin Neoplasms
T-Lymphocytes, Regulatory
Ultraviolet Therapy
Neoplasms, Radiation-Induced
CHLC DER
description Ultraviolet radiation (UVR) can have a beneficial biologic impact on skin, but it is also the most significant environmental risk factor for skin cancer development. Photocarcinogenesis comprises a complex interplay between the carcinogenic UVR, skin, and the immune system. UVB is absorbed by the superficial skin layers and is mainly responsible for direct DNA damage, which, if unrepaired, can lead to mutations in key cancer genes. UVA is less carcinogenic, penetrates deeper in the dermis, and mainly causes indirect oxidative damage to cellular DNA, proteins, and lipids, via photosensitized reactions. UVR not only induces mutagenesis, altering proliferation and differentiation of skin cells, but also has several immunosuppressive effects that compromise tumor immunosurveillance by impairing antigen presentation, inducing suppressive cells, and modulating the cytokine environment. This review focuses upon molecular and cellular effects of UVR, regarding its role in skin cancer development.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01T00:00:00Z
2017-06-30T15:16:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/2717
url http://hdl.handle.net/10400.17/2717
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clin Dermatol. 2016 Sep-Oct;34(5):563-70
10.1016/j.clindermatol.2016.05.022
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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