Preserved monocyte-derived dendritic cell differentiation and maturation in the presence of HIV-2 envelope

Detalhes bibliográficos
Autor(a) principal: Cavaleiro, R.
Data de Publicação: 2009
Outros Autores: Baptista, A. P., Foxall, R. B., Victorino, R. M., Sousa, A. E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/18440
Resumo: © 2012 Mary Ann Liebert, Inc. publishers. All rights reserved, USA and worldwide.
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spelling Preserved monocyte-derived dendritic cell differentiation and maturation in the presence of HIV-2 envelopeHIV-2HIV envelope proteinsgp105HIV immunopathogenesisDendritic cells© 2012 Mary Ann Liebert, Inc. publishers. All rights reserved, USA and worldwide.Dendritic cells (DCs) are fundamental for the initiation of immune responses and are important players in AIDS immunopathogenesis. Impairment of DC function may result from bystander effects of HIV-1 envelope proteins independently of direct HIV-1 infection. HIV-2 envelope proteins are thought to interact with a broader range of receptors than those of HIV-1, and have been shown to have T cell immunosuppressive properties mediated by monocytes. The effects of HIV-2 envelope on DC differentiation and maturation were investigated. The modulatory properties of the HIV-2 envelope on DC generated from monocytes were assessed using both recombinant proteins (HIV-2(ROD) and HIV-2(ALI)) and whole chemically inactivated virus (aldrithiol-2-treated HIV-2(ROD)). DC phenotype was assessed by flow cytometry and DC function by their ability to stimulate allogeneic T cells and to produce cytokines. We demonstrate that HIV-2 Env had no effects upon DC differentiation and maturation despite its broad receptor usage and ability to modulate monocyte function. It is plausible to speculate that a reduced ability of the HIV-2 Env to impair myeloid DC function could represent a contributory factor to the relatively benign course of HIV-2 disease.This work was supported by grants from “Fundação para a Ciência e a Tecnologia” (FCT) and by “Programa Operacional Ciência e Inovação 2010” (POCI2010) to AES. RC and RBF received scholarships from FCT co-financed by POCI 2010 and FSE, and AB from GlaxoSmithKline.Mary Ann LiebertRepositório da Universidade de LisboaCavaleiro, R.Baptista, A. P.Foxall, R. B.Victorino, R. M.Sousa, A. E.2015-07-14T14:19:37Z20092009-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/18440engAIDS Research and Human Retroviruses. April 2009, 25(4): 425-4310889-2229http://dx.doi.org/ 10.1089/aid.2008.0247info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:04:32Zoai:repositorio.ul.pt:10451/18440Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:37:54.656203Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Preserved monocyte-derived dendritic cell differentiation and maturation in the presence of HIV-2 envelope
title Preserved monocyte-derived dendritic cell differentiation and maturation in the presence of HIV-2 envelope
spellingShingle Preserved monocyte-derived dendritic cell differentiation and maturation in the presence of HIV-2 envelope
Cavaleiro, R.
HIV-2
HIV envelope proteins
gp105
HIV immunopathogenesis
Dendritic cells
title_short Preserved monocyte-derived dendritic cell differentiation and maturation in the presence of HIV-2 envelope
title_full Preserved monocyte-derived dendritic cell differentiation and maturation in the presence of HIV-2 envelope
title_fullStr Preserved monocyte-derived dendritic cell differentiation and maturation in the presence of HIV-2 envelope
title_full_unstemmed Preserved monocyte-derived dendritic cell differentiation and maturation in the presence of HIV-2 envelope
title_sort Preserved monocyte-derived dendritic cell differentiation and maturation in the presence of HIV-2 envelope
author Cavaleiro, R.
author_facet Cavaleiro, R.
Baptista, A. P.
Foxall, R. B.
Victorino, R. M.
Sousa, A. E.
author_role author
author2 Baptista, A. P.
Foxall, R. B.
Victorino, R. M.
Sousa, A. E.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Cavaleiro, R.
Baptista, A. P.
Foxall, R. B.
Victorino, R. M.
Sousa, A. E.
dc.subject.por.fl_str_mv HIV-2
HIV envelope proteins
gp105
HIV immunopathogenesis
Dendritic cells
topic HIV-2
HIV envelope proteins
gp105
HIV immunopathogenesis
Dendritic cells
description © 2012 Mary Ann Liebert, Inc. publishers. All rights reserved, USA and worldwide.
publishDate 2009
dc.date.none.fl_str_mv 2009
2009-01-01T00:00:00Z
2015-07-14T14:19:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/18440
url http://hdl.handle.net/10451/18440
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv AIDS Research and Human Retroviruses. April 2009, 25(4): 425-431
0889-2229
http://dx.doi.org/ 10.1089/aid.2008.0247
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Mary Ann Liebert
publisher.none.fl_str_mv Mary Ann Liebert
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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