High-resolution mtDNA evidence for the late-glacial resettlement of Europe from an Iberian refugium

Detalhes bibliográficos
Autor(a) principal: Pereira, L
Data de Publicação: 2005
Outros Autores: Richards, M, Goios, A, Alonso, A, Albarrán, C, Garcia, O, Behar, DM, Gölge, M, Hatina, J, Al-Gazali, L, Bradley, DG, Macaulay, V, Amorim, A
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10216/109269
Resumo: The advent of complete mitochondrial DNA (mtDNA) sequence data has ushered in a new phase of human evolutionary studies. Even quite limited volumes of complete mtDNA sequence data can now be used to identify the critical polymorphisms that define sub-clades within an mtDNA haplogroup, providing a springboard for large-scale high-resolution screening of human mtDNAs. This strategy has in the past been applied to mtDNA haplogroup V, which represents <5% of European mtDNAs. Here we adopted a similar approach to haplogroup H, by far the most common European haplogroup, which at lower resolution displayed a rather uninformative frequency distribution within Europe. Using polymorphism information derived from the growing complete mtDNA sequence database, we sequenced 1580 base pairs of targeted coding-region segments of the mtDNA genome in 649 individuals harboring mtDNA haplogroup H from populations throughout Europe, the Caucasus, and the Near East. The enhanced genealogical resolution clearly shows that sub-clades of haplogroup H have highly distinctive geographical distributions. The patterns of frequency and diversity suggest that haplogroup H entered Europe from the Near East approximately 20,000-25,000 years ago, around the time of the Last Glacial Maximum (LGM), and some sub-clades re-expanded from an Iberian refugium when the glaciers retreated approximately 15,000 years ago. This shows that a large fraction of the maternal ancestry of modern Europeans traces back to the expansion of hunter-gatherer populations at the end of the last Ice Age.
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spelling High-resolution mtDNA evidence for the late-glacial resettlement of Europe from an Iberian refugiumDNA Mitochondrial/geneticsElectron Transport Complex IV/geneticsEmigration and ImmigrationEuropeEvolution, MolecularGenetics Population/methodsHaplotypes/geneticsHumansMolecular Sequence DataPortugalSpainThe advent of complete mitochondrial DNA (mtDNA) sequence data has ushered in a new phase of human evolutionary studies. Even quite limited volumes of complete mtDNA sequence data can now be used to identify the critical polymorphisms that define sub-clades within an mtDNA haplogroup, providing a springboard for large-scale high-resolution screening of human mtDNAs. This strategy has in the past been applied to mtDNA haplogroup V, which represents <5% of European mtDNAs. Here we adopted a similar approach to haplogroup H, by far the most common European haplogroup, which at lower resolution displayed a rather uninformative frequency distribution within Europe. Using polymorphism information derived from the growing complete mtDNA sequence database, we sequenced 1580 base pairs of targeted coding-region segments of the mtDNA genome in 649 individuals harboring mtDNA haplogroup H from populations throughout Europe, the Caucasus, and the Near East. The enhanced genealogical resolution clearly shows that sub-clades of haplogroup H have highly distinctive geographical distributions. The patterns of frequency and diversity suggest that haplogroup H entered Europe from the Near East approximately 20,000-25,000 years ago, around the time of the Last Glacial Maximum (LGM), and some sub-clades re-expanded from an Iberian refugium when the glaciers retreated approximately 15,000 years ago. This shows that a large fraction of the maternal ancestry of modern Europeans traces back to the expansion of hunter-gatherer populations at the end of the last Ice Age.Cold Spring Harbor Laboratory Press20052005-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10216/109269eng1088-905110.1101/gr.3182305Pereira, LRichards, MGoios, AAlonso, AAlbarrán, CGarcia, OBehar, DMGölge, MHatina, JAl-Gazali, LBradley, DGMacaulay, VAmorim, Ainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T13:00:17Zoai:repositorio-aberto.up.pt:10216/109269Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:31:32.756497Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv High-resolution mtDNA evidence for the late-glacial resettlement of Europe from an Iberian refugium
title High-resolution mtDNA evidence for the late-glacial resettlement of Europe from an Iberian refugium
spellingShingle High-resolution mtDNA evidence for the late-glacial resettlement of Europe from an Iberian refugium
Pereira, L
DNA Mitochondrial/genetics
Electron Transport Complex IV/genetics
Emigration and Immigration
Europe
Evolution, Molecular
Genetics Population/methods
Haplotypes/genetics
Humans
Molecular Sequence Data
Portugal
Spain
title_short High-resolution mtDNA evidence for the late-glacial resettlement of Europe from an Iberian refugium
title_full High-resolution mtDNA evidence for the late-glacial resettlement of Europe from an Iberian refugium
title_fullStr High-resolution mtDNA evidence for the late-glacial resettlement of Europe from an Iberian refugium
title_full_unstemmed High-resolution mtDNA evidence for the late-glacial resettlement of Europe from an Iberian refugium
title_sort High-resolution mtDNA evidence for the late-glacial resettlement of Europe from an Iberian refugium
author Pereira, L
author_facet Pereira, L
Richards, M
Goios, A
Alonso, A
Albarrán, C
Garcia, O
Behar, DM
Gölge, M
Hatina, J
Al-Gazali, L
Bradley, DG
Macaulay, V
Amorim, A
author_role author
author2 Richards, M
Goios, A
Alonso, A
Albarrán, C
Garcia, O
Behar, DM
Gölge, M
Hatina, J
Al-Gazali, L
Bradley, DG
Macaulay, V
Amorim, A
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pereira, L
Richards, M
Goios, A
Alonso, A
Albarrán, C
Garcia, O
Behar, DM
Gölge, M
Hatina, J
Al-Gazali, L
Bradley, DG
Macaulay, V
Amorim, A
dc.subject.por.fl_str_mv DNA Mitochondrial/genetics
Electron Transport Complex IV/genetics
Emigration and Immigration
Europe
Evolution, Molecular
Genetics Population/methods
Haplotypes/genetics
Humans
Molecular Sequence Data
Portugal
Spain
topic DNA Mitochondrial/genetics
Electron Transport Complex IV/genetics
Emigration and Immigration
Europe
Evolution, Molecular
Genetics Population/methods
Haplotypes/genetics
Humans
Molecular Sequence Data
Portugal
Spain
description The advent of complete mitochondrial DNA (mtDNA) sequence data has ushered in a new phase of human evolutionary studies. Even quite limited volumes of complete mtDNA sequence data can now be used to identify the critical polymorphisms that define sub-clades within an mtDNA haplogroup, providing a springboard for large-scale high-resolution screening of human mtDNAs. This strategy has in the past been applied to mtDNA haplogroup V, which represents <5% of European mtDNAs. Here we adopted a similar approach to haplogroup H, by far the most common European haplogroup, which at lower resolution displayed a rather uninformative frequency distribution within Europe. Using polymorphism information derived from the growing complete mtDNA sequence database, we sequenced 1580 base pairs of targeted coding-region segments of the mtDNA genome in 649 individuals harboring mtDNA haplogroup H from populations throughout Europe, the Caucasus, and the Near East. The enhanced genealogical resolution clearly shows that sub-clades of haplogroup H have highly distinctive geographical distributions. The patterns of frequency and diversity suggest that haplogroup H entered Europe from the Near East approximately 20,000-25,000 years ago, around the time of the Last Glacial Maximum (LGM), and some sub-clades re-expanded from an Iberian refugium when the glaciers retreated approximately 15,000 years ago. This shows that a large fraction of the maternal ancestry of modern Europeans traces back to the expansion of hunter-gatherer populations at the end of the last Ice Age.
publishDate 2005
dc.date.none.fl_str_mv 2005
2005-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10216/109269
url http://hdl.handle.net/10216/109269
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1088-9051
10.1101/gr.3182305
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Cold Spring Harbor Laboratory Press
publisher.none.fl_str_mv Cold Spring Harbor Laboratory Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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