Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis

• Autor(a) principal: Carvalho, Agostinho
• Data de Publicação: 2008
• Outros Autores: Pasqualotto, A. C., Pitzurra, L., Romani, L, Denning, D. W., Rodrigues, Fernando José dos Santos
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/1822/61456
• topic: Aged; Aspergillosis; Aspergillosis, Allergic Bronchopulmonary; Aspergillus fumigatus; Case-Control Studies; Cohort Studies; Female; Humans; Lung Diseases, Fungal; Male; Middle Aged; Polymorphism, Single Nucleotide; Toll-Like Receptor 2; Toll-Like Receptor 4; Toll-Like Receptor 9; Science & Technology

Toll-like receptors (TLRs) are important components of innate immunity. We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46; P =.003). Susceptibility to allergic bronchopulmonary aspergillosis was associated with allele C on T-1237C (TLR9) (OR, 2.49; P =. 043). No particular polymorphism was associated with severe asthma with fungal sensitization. These findings reinforce the importance of innate immunity in the pathogenesis of different forms of aspergillosis.