Numerical modelling of the hypothalamus under impact
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Tipo de documento: | Dissertação |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/35945 |
Resumo: | Traumatic brain injuries (TBI) are a leading cause of death and disability. This type of injury occurs when a load exceeds the tolerance level of brain tissue and can cause specific damage to the hypothalamus and hippocampus. Injuries present a major cause of long-term disability among survivors. One of the UN Sustainable Development Goals for 2030 is to ensure a healthy life and promote well-being for one and all, at all ages. Computational modelling has been widely used in order to investigate the mechanisms of traumatic injuries. The work developed in this dissertation aims to create a detailed 3D model of the brain structure, Female Finite Element Head Model (FeFEHM), providing a model of the hypothalamus, in order to simulate the impact and evaluate the injuries that occur. Medical images were used to create the 3D model. The material properties were validated according to the study by Menichetti et al.(2020) Two simulations were performed: one according to the study by Alshareef et al.(2018), where a pure coronal rotation was applied and the brain displacement was verified, and a second one that allowed to evaluate the stresses and strains taking into account data from the study by Hernandez et al.(2015). Both simulations showed satisfactory results and good indications for future work. |
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Numerical modelling of the hypothalamus under impactTraumatic brain injuryFinite element analysisHypothalamusPituitary glandBrain modellingWomenTraumatic brain injuries (TBI) are a leading cause of death and disability. This type of injury occurs when a load exceeds the tolerance level of brain tissue and can cause specific damage to the hypothalamus and hippocampus. Injuries present a major cause of long-term disability among survivors. One of the UN Sustainable Development Goals for 2030 is to ensure a healthy life and promote well-being for one and all, at all ages. Computational modelling has been widely used in order to investigate the mechanisms of traumatic injuries. The work developed in this dissertation aims to create a detailed 3D model of the brain structure, Female Finite Element Head Model (FeFEHM), providing a model of the hypothalamus, in order to simulate the impact and evaluate the injuries that occur. Medical images were used to create the 3D model. The material properties were validated according to the study by Menichetti et al.(2020) Two simulations were performed: one according to the study by Alshareef et al.(2018), where a pure coronal rotation was applied and the brain displacement was verified, and a second one that allowed to evaluate the stresses and strains taking into account data from the study by Hernandez et al.(2015). Both simulations showed satisfactory results and good indications for future work.As lesões traumáticas cerebrais são uma das principais causas de morte e incapacidade. Este tipo de lesão ocorre quando uma carga excede o nível de tolerância do tecido cerebral e pode causar danos específicos no hipotálamo e no hipocampo. As lesões apresentam uma causa importante de deficiência a longo prazo entre os sobreviventes. Um dos objetivos de desenvolvimento sustentável para 2030 da ONU é assegurar uma vida saudável e promover o bem-estar para todas e todos, em todas as idades. A modelação computacional tem sido amplamente utilizada a fim de investigar os mecanismos de lesões traumáticas. O trabalho desenvolvido nesta dissertação tem como objetivo criar um modelo detalhado em 3D do estrutura cerebral, Modelo Feminino de Cabeça de Elemento Finito (FeFEHM), fornecendo um modelo do hipotálamo, a fim de simular o impacto e avaliar as lesões que ocorrem. Foram utilizadas imagens médicas para criação do modelo 3D. As propriedades materiais foram validadas de acordo com o estudo de Menichetti et al. (2020). Foram feitas duas simulações: uma de acordo com o estudo de Alshareef et al. (2018), onde se aplicou uma rotação pura coronal e se verificou o deslocamento cerebral e uma segunda que permitiu avaliar as tensões e deformações tendo em conta dados do estudo de Hernandez et al. (2015). Ambas as simulações mostraram resultados satisfatórias e boas indicações para futuros trabalhos.2023-01-23T13:06:08Z2022-11-08T00:00:00Z2022-11-08info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10773/35945engCorreia, Ana Rita Fariainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:09:28Zoai:ria.ua.pt:10773/35945Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:06:57.478790Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Numerical modelling of the hypothalamus under impact |
title |
Numerical modelling of the hypothalamus under impact |
spellingShingle |
Numerical modelling of the hypothalamus under impact Correia, Ana Rita Faria Traumatic brain injury Finite element analysis Hypothalamus Pituitary gland Brain modelling Women |
title_short |
Numerical modelling of the hypothalamus under impact |
title_full |
Numerical modelling of the hypothalamus under impact |
title_fullStr |
Numerical modelling of the hypothalamus under impact |
title_full_unstemmed |
Numerical modelling of the hypothalamus under impact |
title_sort |
Numerical modelling of the hypothalamus under impact |
author |
Correia, Ana Rita Faria |
author_facet |
Correia, Ana Rita Faria |
author_role |
author |
dc.contributor.author.fl_str_mv |
Correia, Ana Rita Faria |
dc.subject.por.fl_str_mv |
Traumatic brain injury Finite element analysis Hypothalamus Pituitary gland Brain modelling Women |
topic |
Traumatic brain injury Finite element analysis Hypothalamus Pituitary gland Brain modelling Women |
description |
Traumatic brain injuries (TBI) are a leading cause of death and disability. This type of injury occurs when a load exceeds the tolerance level of brain tissue and can cause specific damage to the hypothalamus and hippocampus. Injuries present a major cause of long-term disability among survivors. One of the UN Sustainable Development Goals for 2030 is to ensure a healthy life and promote well-being for one and all, at all ages. Computational modelling has been widely used in order to investigate the mechanisms of traumatic injuries. The work developed in this dissertation aims to create a detailed 3D model of the brain structure, Female Finite Element Head Model (FeFEHM), providing a model of the hypothalamus, in order to simulate the impact and evaluate the injuries that occur. Medical images were used to create the 3D model. The material properties were validated according to the study by Menichetti et al.(2020) Two simulations were performed: one according to the study by Alshareef et al.(2018), where a pure coronal rotation was applied and the brain displacement was verified, and a second one that allowed to evaluate the stresses and strains taking into account data from the study by Hernandez et al.(2015). Both simulations showed satisfactory results and good indications for future work. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-11-08T00:00:00Z 2022-11-08 2023-01-23T13:06:08Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/35945 |
url |
http://hdl.handle.net/10773/35945 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137724921282560 |