Controlled delivery of gold nanoparticle-coupled miRNA therapeutics via an injectable self-healing hydrogel

• Autor(a) principal: van der Ven, Casper F T
• Data de Publicação: 2021
• Outros Autores: Tibbitt, Mark W, Conde, João, van Mil, Alain, Hjortnaes, Jesper, Doevendans, Pieter A, Sluijter, Joost P G, Aikawa, Elena, Langer, Robert S
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10362/128611
• topic: SDG 3 - Good Health and Well-being

This research was funded by the National Institutes of Health (NIH) R01 grants R01HL 141719, R01HL136431 and R01HL147095 (E.A.); the National Institutes of Health grant EB000244 (to R.L.); the Netherlands CardioVascular Research Initiative (CVON: The Dutch Heart Foundation, Dutch Federation of University Medical Centers, the Netherlands Organization for Health Research and Development, and the Royal Netherlands Academy of Science) and Vrienden UMC Utrecht (C.V., J.S.); an unrestricted grant from CELLINK to Vrienden UMC Utrecht (C.V., J.S.); the Harvard Catalyst Advanced Microscopy Pilot grants (C.V., E.A.); and the NIH Ruth L. Kirschstein National Research Service Award F32HL122009 (M.W.T.). J.C. acknowledges the European Research Council Starting Grant (ERC-StG-2019-848325). This work was conducted with support from Harvard Catalyst | The Harvard Clinical and Translational Science Center (National Center for Advancing Translational Sciences, National Institutes of Health Award UL1 TR001102) and financial contributions from Harvard University and its affiliated academic healthcare centers. We thank the Harvard Center for Biological Imaging for infrastructure and support, in particular Dr D. Richardson and S. Terclavers. The authors would like to thank Elia Guzzi for assistance with hydrogel preparation.