Fever and Generalised Lymphadenopathy in an HIV-Positive Patient: a Diagnostic Challenge
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/2747 |
Resumo: | Fever and generalised lymphadenopathy is a common presentation of a variety of diseases and a thorough investigation is often necessary for appropriate diagnosis.We present a 53-year-old male patient admitted with fever, weight loss of 15 kg in 3 months and abdominal discomfort. Examination was only remarkable for axillary and inguinal lymphadenopathy. Blood tests showed normocytic normochromic anaemia, cholestasis and a previously unknown HIV-1 infection with lymphocyte CD4 +count of 239 cells/mm(3) and viral load 3.172.370 copies/mL. A body CT scan showed multiple axillary, mediastinal, lumbar, aortic, iliac and pelvic lymphadenopathy as well as hepatosplenomegaly. An excisional biopsy of the left axillary lymphadenopathy was performed and histology ultimately revealed multicentric Castleman's disease associated with Human Herpes Virus-8. After initiation of antiretroviral therapy, rituximab was given and progressive clinical improvement occurred. |
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Fever and Generalised Lymphadenopathy in an HIV-Positive Patient: a Diagnostic ChallengeCHLC ANPATCastleman Disease/complicationsCastleman Disease/diagnosisCastleman Disease/diagnostic imagingDiagnosis, DifferentialFever/etiologyHIV InfectionsLymphadenopathy/etiologyViral LoadFever and generalised lymphadenopathy is a common presentation of a variety of diseases and a thorough investigation is often necessary for appropriate diagnosis.We present a 53-year-old male patient admitted with fever, weight loss of 15 kg in 3 months and abdominal discomfort. Examination was only remarkable for axillary and inguinal lymphadenopathy. Blood tests showed normocytic normochromic anaemia, cholestasis and a previously unknown HIV-1 infection with lymphocyte CD4 +count of 239 cells/mm(3) and viral load 3.172.370 copies/mL. A body CT scan showed multiple axillary, mediastinal, lumbar, aortic, iliac and pelvic lymphadenopathy as well as hepatosplenomegaly. An excisional biopsy of the left axillary lymphadenopathy was performed and histology ultimately revealed multicentric Castleman's disease associated with Human Herpes Virus-8. After initiation of antiretroviral therapy, rituximab was given and progressive clinical improvement occurred.BMJ Publishing GroupRepositório do Centro Hospitalar Universitário de Lisboa Central, EPENeves, BRaimundo, PFarinha, P2017-09-15T14:36:43Z2017-08-162017-08-16T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/2747engBMJ Case Rep. 2017 Aug 16;2017. pii: bcr-2017-220740.10.1136/bcr-2017-220740info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:39:25Zoai:repositorio.chlc.min-saude.pt:10400.17/2747Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:20:04.826559Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Fever and Generalised Lymphadenopathy in an HIV-Positive Patient: a Diagnostic Challenge |
title |
Fever and Generalised Lymphadenopathy in an HIV-Positive Patient: a Diagnostic Challenge |
spellingShingle |
Fever and Generalised Lymphadenopathy in an HIV-Positive Patient: a Diagnostic Challenge Neves, B CHLC ANPAT Castleman Disease/complications Castleman Disease/diagnosis Castleman Disease/diagnostic imaging Diagnosis, Differential Fever/etiology HIV Infections Lymphadenopathy/etiology Viral Load |
title_short |
Fever and Generalised Lymphadenopathy in an HIV-Positive Patient: a Diagnostic Challenge |
title_full |
Fever and Generalised Lymphadenopathy in an HIV-Positive Patient: a Diagnostic Challenge |
title_fullStr |
Fever and Generalised Lymphadenopathy in an HIV-Positive Patient: a Diagnostic Challenge |
title_full_unstemmed |
Fever and Generalised Lymphadenopathy in an HIV-Positive Patient: a Diagnostic Challenge |
title_sort |
Fever and Generalised Lymphadenopathy in an HIV-Positive Patient: a Diagnostic Challenge |
author |
Neves, B |
author_facet |
Neves, B Raimundo, P Farinha, P |
author_role |
author |
author2 |
Raimundo, P Farinha, P |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Neves, B Raimundo, P Farinha, P |
dc.subject.por.fl_str_mv |
CHLC ANPAT Castleman Disease/complications Castleman Disease/diagnosis Castleman Disease/diagnostic imaging Diagnosis, Differential Fever/etiology HIV Infections Lymphadenopathy/etiology Viral Load |
topic |
CHLC ANPAT Castleman Disease/complications Castleman Disease/diagnosis Castleman Disease/diagnostic imaging Diagnosis, Differential Fever/etiology HIV Infections Lymphadenopathy/etiology Viral Load |
description |
Fever and generalised lymphadenopathy is a common presentation of a variety of diseases and a thorough investigation is often necessary for appropriate diagnosis.We present a 53-year-old male patient admitted with fever, weight loss of 15 kg in 3 months and abdominal discomfort. Examination was only remarkable for axillary and inguinal lymphadenopathy. Blood tests showed normocytic normochromic anaemia, cholestasis and a previously unknown HIV-1 infection with lymphocyte CD4 +count of 239 cells/mm(3) and viral load 3.172.370 copies/mL. A body CT scan showed multiple axillary, mediastinal, lumbar, aortic, iliac and pelvic lymphadenopathy as well as hepatosplenomegaly. An excisional biopsy of the left axillary lymphadenopathy was performed and histology ultimately revealed multicentric Castleman's disease associated with Human Herpes Virus-8. After initiation of antiretroviral therapy, rituximab was given and progressive clinical improvement occurred. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-09-15T14:36:43Z 2017-08-16 2017-08-16T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/2747 |
url |
http://hdl.handle.net/10400.17/2747 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
BMJ Case Rep. 2017 Aug 16;2017. pii: bcr-2017-220740. 10.1136/bcr-2017-220740 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
BMJ Publishing Group |
publisher.none.fl_str_mv |
BMJ Publishing Group |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799131297043447808 |