Acute haematogenous osteomyelitis in Lisbon

Detalhes bibliográficos
Autor(a) principal: Gouveia, Catarina
Data de Publicação: 2022
Outros Autores: Branco, Joana, Norte, Susana, Arcangelo, Joana, Alves, Pedro, Pinto, Margarida, Tavares, Delfin
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/150092
Resumo: Copyright © 2021. Published by Elsevier España, S.L.U.
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spelling Acute haematogenous osteomyelitis in Lisbonan unexpectedly high association with myositis and arthritisAdolescentArthritis, Infectious/complicationsChildChild, PreschoolFemaleHumansMaleMyositis/complicationsOsteomyelitis/complicationsRetrospective StudiesStaphylococcus aureusCopyright © 2021. Published by Elsevier España, S.L.U.INTRODUCTION: Despite the current trend toward less aggressive therapeutic approaches, acute haematogenous osteomyelitis (AHO) continues to be a challenge and is associated with significant morbidity worldwide. Our aim was to assess whether compliance with the current protocol was achieved in 80% of cases, to identify complications and the associated risk factors, and to analyse trends in the aetiology and management of AHO in the paediatric population. METHODS: We conducted a longitudinal, observational, single-centre study in patients with AHO aged less than 18 years admitted to a paediatric hospital between 2008 and 2018 divided in 2 cohorts (before and after 2014). We analysed data concerning demographic and clinical characteristics and outcomes. RESULTS: The study included 71 children with AHO, 56% male, with a median age of 3 years (interquartile range, 1-11). We found a 1.8-fold increase of cases in the last 5 years. The causative agent was identified in 37% of cases: MSSA (54%), MRSA (4%), S. pyogenes (19%), K. kingae (12%), S. pneumoniae (8%), and N. meningitidis (4%). Complications were identified in 45% of patients and sequelae in 3.6%. In recent years, there was an increase in myositis (30% vs 7%; P=.02), septic arthritis (68 vs 37.2%; p=0.012) and in the proportion of patients treated for less than 4 weeks (37 vs 3.5%; p=0.012), with a similar sequelae rates. The risk factors associated with complications were age 3 or more years, C-reactive protein levels of 20mg/L or higher, time elapsed between onset and admission of 5 or more days and positive culture, although the only factor that continued to be significantly associated in the multivariate analysis was positive culture. The presence of complications was a risk factor for sequelae at 6 months. CONCLUSIONS: Our study confirms that AHO can be aggressive. The identification of risk factors for complications is essential for management.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNGouveia, CatarinaBranco, JoanaNorte, SusanaArcangelo, JoanaAlves, PedroPinto, MargaridaTavares, Delfin2023-03-06T22:22:56Z2022-022022-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/pdfhttp://hdl.handle.net/10362/150092eng2341-2879PURE: 54675342https://doi.org/10.1016/j.anpede.2020.11.003info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:31:56Zoai:run.unl.pt:10362/150092Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:53:56.889023Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Acute haematogenous osteomyelitis in Lisbon
an unexpectedly high association with myositis and arthritis
title Acute haematogenous osteomyelitis in Lisbon
spellingShingle Acute haematogenous osteomyelitis in Lisbon
Gouveia, Catarina
Adolescent
Arthritis, Infectious/complications
Child
Child, Preschool
Female
Humans
Male
Myositis/complications
Osteomyelitis/complications
Retrospective Studies
Staphylococcus aureus
title_short Acute haematogenous osteomyelitis in Lisbon
title_full Acute haematogenous osteomyelitis in Lisbon
title_fullStr Acute haematogenous osteomyelitis in Lisbon
title_full_unstemmed Acute haematogenous osteomyelitis in Lisbon
title_sort Acute haematogenous osteomyelitis in Lisbon
author Gouveia, Catarina
author_facet Gouveia, Catarina
Branco, Joana
Norte, Susana
Arcangelo, Joana
Alves, Pedro
Pinto, Margarida
Tavares, Delfin
author_role author
author2 Branco, Joana
Norte, Susana
Arcangelo, Joana
Alves, Pedro
Pinto, Margarida
Tavares, Delfin
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Gouveia, Catarina
Branco, Joana
Norte, Susana
Arcangelo, Joana
Alves, Pedro
Pinto, Margarida
Tavares, Delfin
dc.subject.por.fl_str_mv Adolescent
Arthritis, Infectious/complications
Child
Child, Preschool
Female
Humans
Male
Myositis/complications
Osteomyelitis/complications
Retrospective Studies
Staphylococcus aureus
topic Adolescent
Arthritis, Infectious/complications
Child
Child, Preschool
Female
Humans
Male
Myositis/complications
Osteomyelitis/complications
Retrospective Studies
Staphylococcus aureus
description Copyright © 2021. Published by Elsevier España, S.L.U.
publishDate 2022
dc.date.none.fl_str_mv 2022-02
2022-02-01T00:00:00Z
2023-03-06T22:22:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/150092
url http://hdl.handle.net/10362/150092
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2341-2879
PURE: 54675342
https://doi.org/10.1016/j.anpede.2020.11.003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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