Shaping of Hepatic Ischemia/Reperfusion Events: The Crucial Role of Mitochondria

• Autor(a) principal: Teodoro, João S.
• Data de Publicação: 2022
• Outros Autores: Silva, Rui T. da, Machado, Ivo, Panisello-Roselló, Arnau, Roselló-Catafau, Joan, Rolo, Anabela P., Palmeira, Carlos M.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10316/103217; https://doi.org/10.3390/cells11040688
• topic: mitochondria; liver; ischemia/reperfusion; liver surgery; conditioning; Animals; Disease Models, Animal; Ischemia; Mitochondria; Reperfusion; Liver Diseases; Reperfusion Injury

Hepatic ischemia reperfusion injury (HIRI) is a major hurdle in many clinical scenarios, including liver resection and transplantation. Various studies and countless surgical events have led to the observation of a strong correlation between HIRI induced by liver transplantation and early allograft-dysfunction development. The detrimental impact of HIRI has driven the pursuit of new ways to alleviate its adverse effects. At the core of HIRI lies mitochondrial dysfunction. Various studies, from both animal models and in clinical settings, have clearly shown that mitochondrial function is severely hampered by HIRI and that its preservation or restoration is a key indicator of successful organ recovery. Several strategies have been thus implemented throughout the years, targeting mitochondrial function. This work briefly discusses some the most utilized approaches, ranging from surgical practices to pharmacological interventions and highlights how novel strategies can be investigated and implemented by intricately discussing the way mitochondrial function is affected by HIRI.