Bilirubin dependent on UGT1A1 polymorphisms, hemoglobin, fasting time and body mass index

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Carina
Data de Publicação: 2011
Outros Autores: Costa, Elísio, Vieira, Emília, Carvalho, João, Santos, Rosário, Rocha-Pereira, Petronila, Santos-Silva, Alice, Bronze-da-Rocha, Elsa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10198/6145
Resumo: In Press
id RCAP_43f50774eb58c415c922bfa3373381fa
oai_identifier_str oai:bibliotecadigital.ipb.pt:10198/6145
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Bilirubin dependent on UGT1A1 polymorphisms, hemoglobin, fasting time and body mass indexBilirubin levelsUGT1A1Genetic and nongenetic factors hemoglobinGilbert’s syndromeIn PressIn humans, bilirubin levels are influenced by different factors. This study aims to evaluate the influence of several nongenetic factors (hematologic data, smoking status, alcohol intake, fasting time, physical activity, oral contraceptive therapy and caloric intake) and the genetic contribution of UGT1A1 polymorphisms for the bilirubin levels, in a cohort of young women. Hematologic data, bilirubin and screening of TA duplication in the TATA box region of the UGT1A1 gene were performed in 146 young white women. Body mass index (BMI) and body fat were determined, and a questionnaire about fasting time, smoking habits, oral contraceptive therapy, caloric intake and physical activity was performed. Participants were divided into 3 groups according to the tertiles of bilirubin levels. Subjects from the second and third tertile had significant increases in hemoglobin (Hb) concentration, hematocrit, mean cell Hb and mean cell Hb concentration compared with those in the first tertile. Red blood cell count was significantly increased in subjects in the third tertile. A significant increased frequency was found for the c.-41_-40dupTA allele in homozygosity for both second and third tertiles. Multiple linear regression analysis showed that the c.-41_-40dupTA allele, Hb, BMI and fasting hours were independent variables associated with bilirubin serum levels. Hb concentration, fasting time and BMI were identified as nongenetic causes, together with the genetic UGT1A1 polymorphisms, as the main factors associated with variations in bilirubin levels in a healthy female population.Bolsa de doutoramento SFRH/BD/42791/2007 da Fundação para a Ciência e Tecnologia (FCT) e Fundo Social Europeu.Lippincott Williams & Wilkins,Biblioteca Digital do IPBRodrigues, CarinaCosta, ElísioVieira, EmíliaCarvalho, JoãoSantos, RosárioRocha-Pereira, PetronilaSantos-Silva, AliceBronze-da-Rocha, Elsa2011-09-16T14:00:46Z20112011-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/6145engRodrigues, Carina; Costa, Elísio; Vieira, Emília; Carvalho, João; Santos, Rosário; Rocha-Pereira, Petronila; Santos-Silva, Alice; Bronze-da-Rocha, Elsa; (2011). Bilirubin dependent on UGT1A1 polymorphisms,hemoglobin, fasting time and body mass índex. American Journal of the Medical Sciences. ISSN 0002-9629. 343:2, p. 114-118.0002-9629doi: 10.1097/MAJ.0b013e318223460f10.1097/MAJ.0b013e318223460finfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:15:38Zoai:bibliotecadigital.ipb.pt:10198/6145Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:58:14.344163Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Bilirubin dependent on UGT1A1 polymorphisms, hemoglobin, fasting time and body mass index
title Bilirubin dependent on UGT1A1 polymorphisms, hemoglobin, fasting time and body mass index
spellingShingle Bilirubin dependent on UGT1A1 polymorphisms, hemoglobin, fasting time and body mass index
Rodrigues, Carina
Bilirubin levels
UGT1A1
Genetic and nongenetic factors hemoglobin
Gilbert’s syndrome
title_short Bilirubin dependent on UGT1A1 polymorphisms, hemoglobin, fasting time and body mass index
title_full Bilirubin dependent on UGT1A1 polymorphisms, hemoglobin, fasting time and body mass index
title_fullStr Bilirubin dependent on UGT1A1 polymorphisms, hemoglobin, fasting time and body mass index
title_full_unstemmed Bilirubin dependent on UGT1A1 polymorphisms, hemoglobin, fasting time and body mass index
title_sort Bilirubin dependent on UGT1A1 polymorphisms, hemoglobin, fasting time and body mass index
author Rodrigues, Carina
author_facet Rodrigues, Carina
Costa, Elísio
Vieira, Emília
Carvalho, João
Santos, Rosário
Rocha-Pereira, Petronila
Santos-Silva, Alice
Bronze-da-Rocha, Elsa
author_role author
author2 Costa, Elísio
Vieira, Emília
Carvalho, João
Santos, Rosário
Rocha-Pereira, Petronila
Santos-Silva, Alice
Bronze-da-Rocha, Elsa
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Biblioteca Digital do IPB
dc.contributor.author.fl_str_mv Rodrigues, Carina
Costa, Elísio
Vieira, Emília
Carvalho, João
Santos, Rosário
Rocha-Pereira, Petronila
Santos-Silva, Alice
Bronze-da-Rocha, Elsa
dc.subject.por.fl_str_mv Bilirubin levels
UGT1A1
Genetic and nongenetic factors hemoglobin
Gilbert’s syndrome
topic Bilirubin levels
UGT1A1
Genetic and nongenetic factors hemoglobin
Gilbert’s syndrome
description In Press
publishDate 2011
dc.date.none.fl_str_mv 2011-09-16T14:00:46Z
2011
2011-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10198/6145
url http://hdl.handle.net/10198/6145
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Rodrigues, Carina; Costa, Elísio; Vieira, Emília; Carvalho, João; Santos, Rosário; Rocha-Pereira, Petronila; Santos-Silva, Alice; Bronze-da-Rocha, Elsa; (2011). Bilirubin dependent on UGT1A1 polymorphisms,hemoglobin, fasting time and body mass índex. American Journal of the Medical Sciences. ISSN 0002-9629. 343:2, p. 114-118.
0002-9629
doi: 10.1097/MAJ.0b013e318223460f
10.1097/MAJ.0b013e318223460f
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams & Wilkins,
publisher.none.fl_str_mv Lippincott Williams & Wilkins,
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799135200819544064

Registros relacionados