Stereology in Grading and Prognosis of Canine Cutaneous Mast Cell Tumors
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10174/29328 |
Resumo: | Canine cutaneous mast cell tumors (ccMCTs) are currently graded according to Patnaik and Kiupel grading schemes. The qualitative and semiquantitative parameters applied in these schemes may lead to inter- and intraobserver variability. This study investigates the prognostic value of volume-weighted mean nuclear volume (v v ), a stereological estimation that provides information about nuclear size and its variability. v v of 55 ccMCTs was estimated using the “point-sampled intercept” method and compared with histological grade and clinical outcome. The clinical history of dogs treated with surgical excision alone was available for 30 ccMCTs. Statistical differences in v v were found between grade II ((x =115 + 29 mm)3 and grade III ccMCTs (x ¼ 197+ 63 mm)3, as well as between low-grade (x ¼ 113+ 28 mm)3 and high-grade ccMCTs (x ¼ 184+ 63 mm)3. An optimal cutoff value of v v 150 mm3 and v v 140 mm3 was determined for grade III and high-grade ccMCTs, respectively. In terms of prognosis, v v was not able to predict the clinical outcome in 42% of the cases; however, cases with v v <125 mm3 had a favorable outcome. These results indicate that, despite having limited prognostic value when used as a solitary parameter, v v is highly reproducible and is associated with histological grade as well as with benign behavior. |
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Stereology in Grading and Prognosis of Canine Cutaneous Mast Cell Tumorsdogsmast cell tumormean nuclear volumestereologyskinhistological gradingCanine cutaneous mast cell tumors (ccMCTs) are currently graded according to Patnaik and Kiupel grading schemes. The qualitative and semiquantitative parameters applied in these schemes may lead to inter- and intraobserver variability. This study investigates the prognostic value of volume-weighted mean nuclear volume (v v ), a stereological estimation that provides information about nuclear size and its variability. v v of 55 ccMCTs was estimated using the “point-sampled intercept” method and compared with histological grade and clinical outcome. The clinical history of dogs treated with surgical excision alone was available for 30 ccMCTs. Statistical differences in v v were found between grade II ((x =115 + 29 mm)3 and grade III ccMCTs (x ¼ 197+ 63 mm)3, as well as between low-grade (x ¼ 113+ 28 mm)3 and high-grade ccMCTs (x ¼ 184+ 63 mm)3. An optimal cutoff value of v v 150 mm3 and v v 140 mm3 was determined for grade III and high-grade ccMCTs, respectively. In terms of prognosis, v v was not able to predict the clinical outcome in 42% of the cases; however, cases with v v <125 mm3 had a favorable outcome. These results indicate that, despite having limited prognostic value when used as a solitary parameter, v v is highly reproducible and is associated with histological grade as well as with benign behavior.journals.sagepub.com/home/vet2021-03-23T15:49:33Z2021-03-232021-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/29328http://hdl.handle.net/10174/29328engCasanova M, Branco S, Veiga IB, Barros A, Faísca P. Stereology in Grading and Prognosis of Canine Cutaneous Mast Cell Tumors. Vet Pathol. 2021 Feb 12:300985820985138. doi: 10.1177/0300985820985138. Epub ahead of print. PMID: 33576305.https://journals.sagepub.com/doi/10.1177/0300985820985138ndsmbb@uevora.ptndndndDOI: 10.1177/0300985820985138Casanova, MafaldaBranco, SandraVeiga, Inês BerenguerBarros, AndréFaísca, Pedroinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-08T04:41:51ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Stereology in Grading and Prognosis of Canine Cutaneous Mast Cell Tumors |
title |
Stereology in Grading and Prognosis of Canine Cutaneous Mast Cell Tumors |
spellingShingle |
Stereology in Grading and Prognosis of Canine Cutaneous Mast Cell Tumors Casanova, Mafalda dogs mast cell tumor mean nuclear volume stereology skin histological grading |
title_short |
Stereology in Grading and Prognosis of Canine Cutaneous Mast Cell Tumors |
title_full |
Stereology in Grading and Prognosis of Canine Cutaneous Mast Cell Tumors |
title_fullStr |
Stereology in Grading and Prognosis of Canine Cutaneous Mast Cell Tumors |
title_full_unstemmed |
Stereology in Grading and Prognosis of Canine Cutaneous Mast Cell Tumors |
title_sort |
Stereology in Grading and Prognosis of Canine Cutaneous Mast Cell Tumors |
author |
Casanova, Mafalda |
author_facet |
Casanova, Mafalda Branco, Sandra Veiga, Inês Berenguer Barros, André Faísca, Pedro |
author_role |
author |
author2 |
Branco, Sandra Veiga, Inês Berenguer Barros, André Faísca, Pedro |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Casanova, Mafalda Branco, Sandra Veiga, Inês Berenguer Barros, André Faísca, Pedro |
dc.subject.por.fl_str_mv |
dogs mast cell tumor mean nuclear volume stereology skin histological grading |
topic |
dogs mast cell tumor mean nuclear volume stereology skin histological grading |
description |
Canine cutaneous mast cell tumors (ccMCTs) are currently graded according to Patnaik and Kiupel grading schemes. The qualitative and semiquantitative parameters applied in these schemes may lead to inter- and intraobserver variability. This study investigates the prognostic value of volume-weighted mean nuclear volume (v v ), a stereological estimation that provides information about nuclear size and its variability. v v of 55 ccMCTs was estimated using the “point-sampled intercept” method and compared with histological grade and clinical outcome. The clinical history of dogs treated with surgical excision alone was available for 30 ccMCTs. Statistical differences in v v were found between grade II ((x =115 + 29 mm)3 and grade III ccMCTs (x ¼ 197+ 63 mm)3, as well as between low-grade (x ¼ 113+ 28 mm)3 and high-grade ccMCTs (x ¼ 184+ 63 mm)3. An optimal cutoff value of v v 150 mm3 and v v 140 mm3 was determined for grade III and high-grade ccMCTs, respectively. In terms of prognosis, v v was not able to predict the clinical outcome in 42% of the cases; however, cases with v v <125 mm3 had a favorable outcome. These results indicate that, despite having limited prognostic value when used as a solitary parameter, v v is highly reproducible and is associated with histological grade as well as with benign behavior. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-03-23T15:49:33Z 2021-03-23 2021-02-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10174/29328 http://hdl.handle.net/10174/29328 |
url |
http://hdl.handle.net/10174/29328 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Casanova M, Branco S, Veiga IB, Barros A, Faísca P. Stereology in Grading and Prognosis of Canine Cutaneous Mast Cell Tumors. Vet Pathol. 2021 Feb 12:300985820985138. doi: 10.1177/0300985820985138. Epub ahead of print. PMID: 33576305. https://journals.sagepub.com/doi/10.1177/0300985820985138 nd smbb@uevora.pt nd nd nd DOI: 10.1177/0300985820985138 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
journals.sagepub.com/home/vet |
publisher.none.fl_str_mv |
journals.sagepub.com/home/vet |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
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repository.mail.fl_str_mv |
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1777304654100561920 |