Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/28396 |
Resumo: | Exposure to a novel environment triggers the response of several brain areas that regulate emotional behaviors. Here, we studied theta oscillations within the hippocampus (HPC)-amygdala (AMY)-medial prefrontal cortex (mPFC) network in exploration of a novel environment and subsequent familiarization through repeated exposures to that same environment; in addition, we assessed how concomitant stress exposure could disrupt this activity and impair both behavioral processes. Local field potentials (LFP) were simultaneously recorded from dorsal and ventral hippocampus (dHPC and vHPC, respectively), basolateral amygdala (BLA) and mPFC in freely behaving rats while they were exposed to a novel environment, then repeatedly re-exposed over the course of 3 weeks to that same environment and, finally, on re-exposure to a novel unfamiliar environment. A longitudinal analysis of theta activity within this circuit revealed a reduction of vHPC and BLA theta power and vHPC-BLA theta coherence through familiarization which was correlated with a return to normal exploratory behavior in control rats. In contrast, a persistent over-activation of the same brain regions was observed in stressed rats that displayed impairments in novel exploration and familiarization processes. Importantly, we show that stress also affected intra-hippocampal synchrony and heightened the coherence between vHPC and BLA. In summary, we demonstrate that modulatory theta activity in the aforementioned circuit, namely in the vHPC and BLA, is correlated with the expression of anxiety in novelty-induced exploration and familiarization in both normal and pathological conditions. |
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Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarizationStressAnxietyLocal field potentialsVentral hippocampusAmygdalaPre-frontal cortexScience & TechnologyExposure to a novel environment triggers the response of several brain areas that regulate emotional behaviors. Here, we studied theta oscillations within the hippocampus (HPC)-amygdala (AMY)-medial prefrontal cortex (mPFC) network in exploration of a novel environment and subsequent familiarization through repeated exposures to that same environment; in addition, we assessed how concomitant stress exposure could disrupt this activity and impair both behavioral processes. Local field potentials (LFP) were simultaneously recorded from dorsal and ventral hippocampus (dHPC and vHPC, respectively), basolateral amygdala (BLA) and mPFC in freely behaving rats while they were exposed to a novel environment, then repeatedly re-exposed over the course of 3 weeks to that same environment and, finally, on re-exposure to a novel unfamiliar environment. A longitudinal analysis of theta activity within this circuit revealed a reduction of vHPC and BLA theta power and vHPC-BLA theta coherence through familiarization which was correlated with a return to normal exploratory behavior in control rats. In contrast, a persistent over-activation of the same brain regions was observed in stressed rats that displayed impairments in novel exploration and familiarization processes. Importantly, we show that stress also affected intra-hippocampal synchrony and heightened the coherence between vHPC and BLA. In summary, we demonstrate that modulatory theta activity in the aforementioned circuit, namely in the vHPC and BLA, is correlated with the expression of anxiety in novelty-induced exploration and familiarization in both normal and pathological conditions.Luis R. Jacinto was supported by the Portuguese Foundation for Science and Technology (FCT) under grant SFRH/BD/40459/2007. This work was supported by FCT and FEDER funds through Programa Operacional Factores de Competitividade (COMPETE) with project references FCOMP-01-0124-FEDER-021145 (FCT/PTDC/SAU-ENB/118383/2010) and FCOMP-01-0124-FEDER-022674; ADI Project "DoIT-Desenvolvimento e Operacionalizacao da Investigacao de Translacao" ("MyHealth-PPS4"; project no 13853); and a BIAL Foundation Grant (138/2008 to Joao J. Cerqueira).Frontiers MediaUniversidade do MinhoJacinto, L. R.Reis, Joana Vanessa Santos dosDias, N. S.Cerqueira, JoãoCorreia, José H.Sousa, Nuno20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/28396eng1662-515310.3389/fnbeh.2013.00127http://www.frontiersin.org/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:31:47ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization |
title |
Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization |
spellingShingle |
Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization Jacinto, L. R. Stress Anxiety Local field potentials Ventral hippocampus Amygdala Pre-frontal cortex Science & Technology |
title_short |
Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization |
title_full |
Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization |
title_fullStr |
Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization |
title_full_unstemmed |
Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization |
title_sort |
Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization |
author |
Jacinto, L. R. |
author_facet |
Jacinto, L. R. Reis, Joana Vanessa Santos dos Dias, N. S. Cerqueira, João Correia, José H. Sousa, Nuno |
author_role |
author |
author2 |
Reis, Joana Vanessa Santos dos Dias, N. S. Cerqueira, João Correia, José H. Sousa, Nuno |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Jacinto, L. R. Reis, Joana Vanessa Santos dos Dias, N. S. Cerqueira, João Correia, José H. Sousa, Nuno |
dc.subject.por.fl_str_mv |
Stress Anxiety Local field potentials Ventral hippocampus Amygdala Pre-frontal cortex Science & Technology |
topic |
Stress Anxiety Local field potentials Ventral hippocampus Amygdala Pre-frontal cortex Science & Technology |
description |
Exposure to a novel environment triggers the response of several brain areas that regulate emotional behaviors. Here, we studied theta oscillations within the hippocampus (HPC)-amygdala (AMY)-medial prefrontal cortex (mPFC) network in exploration of a novel environment and subsequent familiarization through repeated exposures to that same environment; in addition, we assessed how concomitant stress exposure could disrupt this activity and impair both behavioral processes. Local field potentials (LFP) were simultaneously recorded from dorsal and ventral hippocampus (dHPC and vHPC, respectively), basolateral amygdala (BLA) and mPFC in freely behaving rats while they were exposed to a novel environment, then repeatedly re-exposed over the course of 3 weeks to that same environment and, finally, on re-exposure to a novel unfamiliar environment. A longitudinal analysis of theta activity within this circuit revealed a reduction of vHPC and BLA theta power and vHPC-BLA theta coherence through familiarization which was correlated with a return to normal exploratory behavior in control rats. In contrast, a persistent over-activation of the same brain regions was observed in stressed rats that displayed impairments in novel exploration and familiarization processes. Importantly, we show that stress also affected intra-hippocampal synchrony and heightened the coherence between vHPC and BLA. In summary, we demonstrate that modulatory theta activity in the aforementioned circuit, namely in the vHPC and BLA, is correlated with the expression of anxiety in novelty-induced exploration and familiarization in both normal and pathological conditions. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013 2013-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/28396 |
url |
http://hdl.handle.net/1822/28396 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1662-5153 10.3389/fnbeh.2013.00127 http://www.frontiersin.org/ |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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1777303779383705600 |