Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/95077 https://doi.org/10.1016/j.bcp.2018.11.020 |
Resumo: | Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by the excessive accumulation of triglycerides in hepatocytes. NAFLD is the most frequent chronic liver disease in developed countries, and is often associated with metabolic disorders such as obesity and type 2 diabetes. NAFLD definition encompasses a spectrum of chronic liver abnormalities, ranging from simple steatosis (NAFL), to steatohepatitis (NASH), significant liver fibrosis, cirrhosis, and hepatocellular carcinoma. NAFLD, therefore, represents a global public health issue. Mitochondrial dysfunction occurs in NAFLD, and contributes to the progression to the necro-inflammatory and fibrotic form (NASH). Disrupted mitochondrial function is associated with a decrease in the energy levels and impaired redox balance, and negatively affects cell survival by altering overall metabolism and subcellular trafficking. Such events reduce the tolerance of hepatocytes towards damaging hits, and favour the injurious effects of extra-cellular factors. Here, we discuss the role of mitochondria in NAFLD and focus on potential therapeutic approaches aimed at preserving mitochondrial function. |
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Targeting mitochondria to oppose the progression of nonalcoholic fatty liver diseaseFatty liver; Mitochondria; Nitrosative stress; Nonalcoholic fatty liver disease; Oxidative stressHepatocytesHumansMitochondria, LiverNon-alcoholic Fatty Liver DiseaseOxidation-ReductionNonalcoholic fatty liver disease (NAFLD) is a condition characterized by the excessive accumulation of triglycerides in hepatocytes. NAFLD is the most frequent chronic liver disease in developed countries, and is often associated with metabolic disorders such as obesity and type 2 diabetes. NAFLD definition encompasses a spectrum of chronic liver abnormalities, ranging from simple steatosis (NAFL), to steatohepatitis (NASH), significant liver fibrosis, cirrhosis, and hepatocellular carcinoma. NAFLD, therefore, represents a global public health issue. Mitochondrial dysfunction occurs in NAFLD, and contributes to the progression to the necro-inflammatory and fibrotic form (NASH). Disrupted mitochondrial function is associated with a decrease in the energy levels and impaired redox balance, and negatively affects cell survival by altering overall metabolism and subcellular trafficking. Such events reduce the tolerance of hepatocytes towards damaging hits, and favour the injurious effects of extra-cellular factors. Here, we discuss the role of mitochondria in NAFLD and focus on potential therapeutic approaches aimed at preserving mitochondrial function.Elsevier2019-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/95077http://hdl.handle.net/10316/95077https://doi.org/10.1016/j.bcp.2018.11.020por00062952https://www.sciencedirect.com/science/article/abs/pii/S0006295218304982?via%3DihubGrattagliano, IgnazioMontezinho, Liliana P.Oliveira, Paulo J.Frühbeck, GemaGómez-Ambrosi, JavierMontecucco, FabrizioCarbone, FedericoWieckowski, Mariusz R.Wang, David Q-HPortincasa, Pieroinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-10-06T10:13:13Zoai:estudogeral.uc.pt:10316/95077Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:13:39.659283Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease |
title |
Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease |
spellingShingle |
Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease Grattagliano, Ignazio Fatty liver; Mitochondria; Nitrosative stress; Nonalcoholic fatty liver disease; Oxidative stress Hepatocytes Humans Mitochondria, Liver Non-alcoholic Fatty Liver Disease Oxidation-Reduction |
title_short |
Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease |
title_full |
Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease |
title_fullStr |
Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease |
title_full_unstemmed |
Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease |
title_sort |
Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease |
author |
Grattagliano, Ignazio |
author_facet |
Grattagliano, Ignazio Montezinho, Liliana P. Oliveira, Paulo J. Frühbeck, Gema Gómez-Ambrosi, Javier Montecucco, Fabrizio Carbone, Federico Wieckowski, Mariusz R. Wang, David Q-H Portincasa, Piero |
author_role |
author |
author2 |
Montezinho, Liliana P. Oliveira, Paulo J. Frühbeck, Gema Gómez-Ambrosi, Javier Montecucco, Fabrizio Carbone, Federico Wieckowski, Mariusz R. Wang, David Q-H Portincasa, Piero |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Grattagliano, Ignazio Montezinho, Liliana P. Oliveira, Paulo J. Frühbeck, Gema Gómez-Ambrosi, Javier Montecucco, Fabrizio Carbone, Federico Wieckowski, Mariusz R. Wang, David Q-H Portincasa, Piero |
dc.subject.por.fl_str_mv |
Fatty liver; Mitochondria; Nitrosative stress; Nonalcoholic fatty liver disease; Oxidative stress Hepatocytes Humans Mitochondria, Liver Non-alcoholic Fatty Liver Disease Oxidation-Reduction |
topic |
Fatty liver; Mitochondria; Nitrosative stress; Nonalcoholic fatty liver disease; Oxidative stress Hepatocytes Humans Mitochondria, Liver Non-alcoholic Fatty Liver Disease Oxidation-Reduction |
description |
Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by the excessive accumulation of triglycerides in hepatocytes. NAFLD is the most frequent chronic liver disease in developed countries, and is often associated with metabolic disorders such as obesity and type 2 diabetes. NAFLD definition encompasses a spectrum of chronic liver abnormalities, ranging from simple steatosis (NAFL), to steatohepatitis (NASH), significant liver fibrosis, cirrhosis, and hepatocellular carcinoma. NAFLD, therefore, represents a global public health issue. Mitochondrial dysfunction occurs in NAFLD, and contributes to the progression to the necro-inflammatory and fibrotic form (NASH). Disrupted mitochondrial function is associated with a decrease in the energy levels and impaired redox balance, and negatively affects cell survival by altering overall metabolism and subcellular trafficking. Such events reduce the tolerance of hepatocytes towards damaging hits, and favour the injurious effects of extra-cellular factors. Here, we discuss the role of mitochondria in NAFLD and focus on potential therapeutic approaches aimed at preserving mitochondrial function. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-02 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/95077 http://hdl.handle.net/10316/95077 https://doi.org/10.1016/j.bcp.2018.11.020 |
url |
http://hdl.handle.net/10316/95077 https://doi.org/10.1016/j.bcp.2018.11.020 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
00062952 https://www.sciencedirect.com/science/article/abs/pii/S0006295218304982?via%3Dihub |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134032316858368 |