Phylogenetic Evidence for the Existence of Multiple Strains of Rickettsia parkeri in the New World

Detalhes bibliográficos
Autor(a) principal: Nieri-Bastos, F.A.
Data de Publicação: 2018
Outros Autores: Marcili, A., de Sousa, R., Paddock, C.D., Labruna, M.B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/6053
Resumo: Free PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881050/
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spelling Phylogenetic Evidence for the Existence of Multiple Strains of Rickettsia parkeri in the New WorldRickettsiaAmblyommaNew WorldRickettsia ParkeriSpotted Fever GroupTick-borne DiseasesInfecções Sistémicas e ZoonosesFree PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881050/The bacterium Rickettsia parkeri has been reported to infect ticks of the "Amblyomma maculatum species complex" in the New World, where it causes spotted fever illness in humans. In South America, three additional rickettsial strains, namely, Atlantic rainforest, NOD, and Parvitarsum, have been isolated from the ticks Amblyomma ovale, Amblyomma nodosum, and Amblyomma parvitarsum, respectively. These three strains are phylogenetically closely related to R. parkeri, Rickettsia africae, and Rickettsia sibirica Herein, we performed a robust phylogenetic analysis encompassing 5 genes (gltA, ompA, virB4, dnaA, and dnaK) and 3 intergenic spacers (mppE-pur, rrl-rrf-ITS, and rpmE-tRNAfMet) from 41 rickettsial isolates, including different isolates of R. parkeri, R. africae, R. sibirica, Rickettsia conorii, and strains Atlantic rainforest, NOD, and Parvitarsum. In our phylogenetic analyses, all New World isolates grouped in a major clade distinct from the Old World Rickettsia species (R. conorii, R. sibirica, and R. africae). This New World clade was subdivided into the following 4 clades: the R. parkerisensu stricto clade, comprising the type strain Maculatum 20 and all other isolates of R. parkeri from North and South America, associated with ticks of the A. maculatum species complex; the strain NOD clade, comprising two South American isolates from A. nodosum ticks; the Parvitarsum clade, comprising two South American isolates from A. parvitarsum ticks; and the strain Atlantic rainforest clade, comprising six South American isolates from the A. ovale species complex (A. ovale or Amblyomma aureolatum). Under such evidences, we propose that strains Atlantic rainforest, NOD, and Parvitarsum are South American strains of R. parkeriIMPORTANCE Since the description of Rickettsia parkeri infecting ticks of the "Amblyomma maculatum species complex" and humans in the New World, three novel phylogenetic close-related rickettsial isolates were reported in South America. Herein, we provide genetic evidence that these novel isolates, namely, strains Atlantic rainforest, NOD, and Parvitarsum, are South American strains of R. parkeri. Interestingly, each of these R. parkeri strains seems to be primarily associated with a tick species group, namely, R. parkerisensu stricto with the "Amblyomma maculatum species group," R. parkeri strain NOD with Amblyomma nodosum, R. parkeri strain Parvitarsum with Amblyomma parvitarsum, and R. parkeri strain Atlantic rainforest with the "Amblyomma ovale species group." Such rickettsial strain-tick species specificity suggests a coevolution of each tick-strain association. Finally, because R. parkerisensu stricto and R. parkeri strain Atlantic rainforest are human pathogens, the potential of R. parkeri strains NOD and Parvitarsum to be human pathogens cannot be discarded.This work was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (grant 2011/51979-1 to F.A.N.-B.) and by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior CAPES/PROEX 1841/2016.American Society for MicrobiologyRepositório Científico do Instituto Nacional de SaúdeNieri-Bastos, F.A.Marcili, A.de Sousa, R.Paddock, C.D.Labruna, M.B.2019-03-04T15:38:40Z2018-04-022018-04-02T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/6053engAppl Environ Microbiol. 2018 Apr 2;84(8). pii: e02872-17. doi: 10.1128/AEM.02872-17. Print 2018 Apr 150099-224010.1128/AEM.02872-17info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:10Zoai:repositorio.insa.pt:10400.18/6053Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:40:41.500035Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Phylogenetic Evidence for the Existence of Multiple Strains of Rickettsia parkeri in the New World
title Phylogenetic Evidence for the Existence of Multiple Strains of Rickettsia parkeri in the New World
spellingShingle Phylogenetic Evidence for the Existence of Multiple Strains of Rickettsia parkeri in the New World
Nieri-Bastos, F.A.
Rickettsia
Amblyomma
New World
Rickettsia Parkeri
Spotted Fever Group
Tick-borne Diseases
Infecções Sistémicas e Zoonoses
title_short Phylogenetic Evidence for the Existence of Multiple Strains of Rickettsia parkeri in the New World
title_full Phylogenetic Evidence for the Existence of Multiple Strains of Rickettsia parkeri in the New World
title_fullStr Phylogenetic Evidence for the Existence of Multiple Strains of Rickettsia parkeri in the New World
title_full_unstemmed Phylogenetic Evidence for the Existence of Multiple Strains of Rickettsia parkeri in the New World
title_sort Phylogenetic Evidence for the Existence of Multiple Strains of Rickettsia parkeri in the New World
author Nieri-Bastos, F.A.
author_facet Nieri-Bastos, F.A.
Marcili, A.
de Sousa, R.
Paddock, C.D.
Labruna, M.B.
author_role author
author2 Marcili, A.
de Sousa, R.
Paddock, C.D.
Labruna, M.B.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Nieri-Bastos, F.A.
Marcili, A.
de Sousa, R.
Paddock, C.D.
Labruna, M.B.
dc.subject.por.fl_str_mv Rickettsia
Amblyomma
New World
Rickettsia Parkeri
Spotted Fever Group
Tick-borne Diseases
Infecções Sistémicas e Zoonoses
topic Rickettsia
Amblyomma
New World
Rickettsia Parkeri
Spotted Fever Group
Tick-borne Diseases
Infecções Sistémicas e Zoonoses
description Free PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881050/
publishDate 2018
dc.date.none.fl_str_mv 2018-04-02
2018-04-02T00:00:00Z
2019-03-04T15:38:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/6053
url http://hdl.handle.net/10400.18/6053
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Appl Environ Microbiol. 2018 Apr 2;84(8). pii: e02872-17. doi: 10.1128/AEM.02872-17. Print 2018 Apr 15
0099-2240
10.1128/AEM.02872-17
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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