Mono- and dicationic DABCO/Quinuclidine composed nanomaterials for the loading of steroidal drug: 32 factorial design and physicochemical characterization

Detalhes bibliográficos
Autor(a) principal: Fernandes, Ana R.
Data de Publicação: 2021
Outros Autores: Sanchez-Lopez, Elena, Santini, Antonello, Santos, Tiago dos, Garcia, Maria L., Silva, Amélia M., Souto, Eliana B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/74405
Resumo: Oil-in-water nanoemulsions (NEs) are considered a suitable nanotechnological approach to improve the eye-related bioavailability of lipophilic drugs. The potential of cationic NEs is prominent due to the electrostatic interaction that occurs between the positively charged droplets with the negatively charged mucins present in the tear film. This interaction offers prolonged NEs residence at the ocular surface, increasing the drug absorption. Triamcinolone acetonide (TA) is one of the first pharmacologic strategies applied as an intravitreal injection in the treatment of age-related macular degeneration (AMD). Newly synthesized quaternary derivatives of 1,4-diazabicyclo[2.2.2]octane (DABCO) and quinuclidine surfactants have been screened with the purpose to select the best compound to formulate long-term stable NEs that combine the best physicochemical properties for the loading of TA intended for ocular administration.
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spelling Mono- and dicationic DABCO/Quinuclidine composed nanomaterials for the loading of steroidal drug: 32 factorial design and physicochemical characterizationCationic nanoemulsionsDABCO surfactantsQuinuclidine surfactantsOcular administrationTriamcinolone acetonideScience & TechnologyOil-in-water nanoemulsions (NEs) are considered a suitable nanotechnological approach to improve the eye-related bioavailability of lipophilic drugs. The potential of cationic NEs is prominent due to the electrostatic interaction that occurs between the positively charged droplets with the negatively charged mucins present in the tear film. This interaction offers prolonged NEs residence at the ocular surface, increasing the drug absorption. Triamcinolone acetonide (TA) is one of the first pharmacologic strategies applied as an intravitreal injection in the treatment of age-related macular degeneration (AMD). Newly synthesized quaternary derivatives of 1,4-diazabicyclo[2.2.2]octane (DABCO) and quinuclidine surfactants have been screened with the purpose to select the best compound to formulate long-term stable NEs that combine the best physicochemical properties for the loading of TA intended for ocular administration.This work was funded by the Portuguese Science and Technology Foundation (FCT) from the Ministry of Science and Technology (MCTES), European Social Fund (FSE) of EU, for the scholar ship SFRH/BD/130555/2017 granted to A. R. Fernandes, and for the projects UIDB/04469/2020 (CEB strategic fund) and UIDB/04033/2020 (CITAB), co-funded by European Funds (PRODER/COMPETE) and FEDER, under the Partnership Agreement PT2020.info:eu-repo/semantics/publishedVersionMDPIUniversidade do MinhoFernandes, Ana R.Sanchez-Lopez, ElenaSantini, AntonelloSantos, Tiago dosGarcia, Maria L.Silva, Amélia M.Souto, Eliana B.2021-10-182021-10-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/74405engFernandes, Ana R.; Sanchez-Lopez, Elena; Santini, Antonello; Santos, Tiago dos; Garcia, Maria L.; Silva, Amélia M.; Souto, Eliana, Mono- and Dicationic DABCO/Quinuclidine Composed Nanomaterials for the Loading of Steroidal Drug: 32 Factorial Design and Physicochemical Characterization. Nanomaterials, 11(10), 2758, 20212079-499110.3390/nano11102758http://www.mdpi.com/journal/nanomaterialsinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:55:55Zoai:repositorium.sdum.uminho.pt:1822/74405Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:45:30.607322Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Mono- and dicationic DABCO/Quinuclidine composed nanomaterials for the loading of steroidal drug: 32 factorial design and physicochemical characterization
title Mono- and dicationic DABCO/Quinuclidine composed nanomaterials for the loading of steroidal drug: 32 factorial design and physicochemical characterization
spellingShingle Mono- and dicationic DABCO/Quinuclidine composed nanomaterials for the loading of steroidal drug: 32 factorial design and physicochemical characterization
Fernandes, Ana R.
Cationic nanoemulsions
DABCO surfactants
Quinuclidine surfactants
Ocular administration
Triamcinolone acetonide
Science & Technology
title_short Mono- and dicationic DABCO/Quinuclidine composed nanomaterials for the loading of steroidal drug: 32 factorial design and physicochemical characterization
title_full Mono- and dicationic DABCO/Quinuclidine composed nanomaterials for the loading of steroidal drug: 32 factorial design and physicochemical characterization
title_fullStr Mono- and dicationic DABCO/Quinuclidine composed nanomaterials for the loading of steroidal drug: 32 factorial design and physicochemical characterization
title_full_unstemmed Mono- and dicationic DABCO/Quinuclidine composed nanomaterials for the loading of steroidal drug: 32 factorial design and physicochemical characterization
title_sort Mono- and dicationic DABCO/Quinuclidine composed nanomaterials for the loading of steroidal drug: 32 factorial design and physicochemical characterization
author Fernandes, Ana R.
author_facet Fernandes, Ana R.
Sanchez-Lopez, Elena
Santini, Antonello
Santos, Tiago dos
Garcia, Maria L.
Silva, Amélia M.
Souto, Eliana B.
author_role author
author2 Sanchez-Lopez, Elena
Santini, Antonello
Santos, Tiago dos
Garcia, Maria L.
Silva, Amélia M.
Souto, Eliana B.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Fernandes, Ana R.
Sanchez-Lopez, Elena
Santini, Antonello
Santos, Tiago dos
Garcia, Maria L.
Silva, Amélia M.
Souto, Eliana B.
dc.subject.por.fl_str_mv Cationic nanoemulsions
DABCO surfactants
Quinuclidine surfactants
Ocular administration
Triamcinolone acetonide
Science & Technology
topic Cationic nanoemulsions
DABCO surfactants
Quinuclidine surfactants
Ocular administration
Triamcinolone acetonide
Science & Technology
description Oil-in-water nanoemulsions (NEs) are considered a suitable nanotechnological approach to improve the eye-related bioavailability of lipophilic drugs. The potential of cationic NEs is prominent due to the electrostatic interaction that occurs between the positively charged droplets with the negatively charged mucins present in the tear film. This interaction offers prolonged NEs residence at the ocular surface, increasing the drug absorption. Triamcinolone acetonide (TA) is one of the first pharmacologic strategies applied as an intravitreal injection in the treatment of age-related macular degeneration (AMD). Newly synthesized quaternary derivatives of 1,4-diazabicyclo[2.2.2]octane (DABCO) and quinuclidine surfactants have been screened with the purpose to select the best compound to formulate long-term stable NEs that combine the best physicochemical properties for the loading of TA intended for ocular administration.
publishDate 2021
dc.date.none.fl_str_mv 2021-10-18
2021-10-18T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/74405
url https://hdl.handle.net/1822/74405
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Fernandes, Ana R.; Sanchez-Lopez, Elena; Santini, Antonello; Santos, Tiago dos; Garcia, Maria L.; Silva, Amélia M.; Souto, Eliana, Mono- and Dicationic DABCO/Quinuclidine Composed Nanomaterials for the Loading of Steroidal Drug: 32 Factorial Design and Physicochemical Characterization. Nanomaterials, 11(10), 2758, 2021
2079-4991
10.3390/nano11102758
http://www.mdpi.com/journal/nanomaterials
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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