In vitro and computational studies of transdermal perfusion of nanoformulations containing a large molecular weight protein

Detalhes bibliográficos
Autor(a) principal: Martins, Margarida Isabel Barros Coelho
Data de Publicação: 2013
Outros Autores: Azóia, Nuno G., Ribeiro, Artur J., Shimanovich, Ulyana, Silva, Carla Manuela Pereira Marinho da, Paulo, Artur Cavaco
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/24342
Resumo: Transdermal perfusion of a large protein is reported for the first time, using a nanoemulsion of bovine serum albumin (66 kDa) of 160 nm prepared by a solid-in-oil (S/O) process. Molecular dynamics simulations confirmed skin permeation by these formulations, with integration of the protein into the lipid bilayers. These results demonstrate the real possibility of delivering large proteins transdermally for a range of medical and cosmetic applications.
id RCAP_46a3869770b83025c07167b18553eb74
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/24342
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling In vitro and computational studies of transdermal perfusion of nanoformulations containing a large molecular weight proteinProteinSurfactantNanodispersionTransdermal perfusionHydrophilic macromoleculesScience & TechnologyTransdermal perfusion of a large protein is reported for the first time, using a nanoemulsion of bovine serum albumin (66 kDa) of 160 nm prepared by a solid-in-oil (S/O) process. Molecular dynamics simulations confirmed skin permeation by these formulations, with integration of the protein into the lipid bilayers. These results demonstrate the real possibility of delivering large proteins transdermally for a range of medical and cosmetic applications.We thank Matadouro - Central Carnes de Entre Douro e Minho, Lda for their support on pig samples. The histological studies were supported by the Department of Histology from Life and Health Sciences Research Institute (ICVS), University of Minho. The confocal 3D images were performed by Department of Chemistry and Kanbar Laboratory for Nanomaterials Bar-Ilan University Center for Advanced Materials and Nanotechnology. Carla Silva would like to thanks Fundacao para a Ciencia e a Tecnologia for their funding (SFRH/BPD/46515/2008).Elsevier Science BVElsevier BVUniversidade do MinhoMartins, Margarida Isabel Barros CoelhoAzóia, Nuno G.Ribeiro, Artur J.Shimanovich, UlyanaSilva, Carla Manuela Pereira Marinho daPaulo, Artur Cavaco20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/24342eng0927-776510.1016/j.colsurfb.2013.02.03223563294http://ac.els-cdn.com/S0927776513001616/1-s2.0-S0927776513001616-main.pdf?_tid=b4f90438-ce03-11e2-b26a-00000aacb35e&acdnat=1370452789_82fbaa692916dc26190e9496b22234cainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:33:04Zoai:repositorium.sdum.uminho.pt:1822/24342Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:28:32.124122Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv In vitro and computational studies of transdermal perfusion of nanoformulations containing a large molecular weight protein
title In vitro and computational studies of transdermal perfusion of nanoformulations containing a large molecular weight protein
spellingShingle In vitro and computational studies of transdermal perfusion of nanoformulations containing a large molecular weight protein
Martins, Margarida Isabel Barros Coelho
Protein
Surfactant
Nanodispersion
Transdermal perfusion
Hydrophilic macromolecules
Science & Technology
title_short In vitro and computational studies of transdermal perfusion of nanoformulations containing a large molecular weight protein
title_full In vitro and computational studies of transdermal perfusion of nanoformulations containing a large molecular weight protein
title_fullStr In vitro and computational studies of transdermal perfusion of nanoformulations containing a large molecular weight protein
title_full_unstemmed In vitro and computational studies of transdermal perfusion of nanoformulations containing a large molecular weight protein
title_sort In vitro and computational studies of transdermal perfusion of nanoformulations containing a large molecular weight protein
author Martins, Margarida Isabel Barros Coelho
author_facet Martins, Margarida Isabel Barros Coelho
Azóia, Nuno G.
Ribeiro, Artur J.
Shimanovich, Ulyana
Silva, Carla Manuela Pereira Marinho da
Paulo, Artur Cavaco
author_role author
author2 Azóia, Nuno G.
Ribeiro, Artur J.
Shimanovich, Ulyana
Silva, Carla Manuela Pereira Marinho da
Paulo, Artur Cavaco
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Martins, Margarida Isabel Barros Coelho
Azóia, Nuno G.
Ribeiro, Artur J.
Shimanovich, Ulyana
Silva, Carla Manuela Pereira Marinho da
Paulo, Artur Cavaco
dc.subject.por.fl_str_mv Protein
Surfactant
Nanodispersion
Transdermal perfusion
Hydrophilic macromolecules
Science & Technology
topic Protein
Surfactant
Nanodispersion
Transdermal perfusion
Hydrophilic macromolecules
Science & Technology
description Transdermal perfusion of a large protein is reported for the first time, using a nanoemulsion of bovine serum albumin (66 kDa) of 160 nm prepared by a solid-in-oil (S/O) process. Molecular dynamics simulations confirmed skin permeation by these formulations, with integration of the protein into the lipid bilayers. These results demonstrate the real possibility of delivering large proteins transdermally for a range of medical and cosmetic applications.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/24342
url http://hdl.handle.net/1822/24342
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0927-7765
10.1016/j.colsurfb.2013.02.032
23563294
http://ac.els-cdn.com/S0927776513001616/1-s2.0-S0927776513001616-main.pdf?_tid=b4f90438-ce03-11e2-b26a-00000aacb35e&acdnat=1370452789_82fbaa692916dc26190e9496b22234ca
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier Science BV
Elsevier BV
publisher.none.fl_str_mv Elsevier Science BV
Elsevier BV
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132781007077376

Registros relacionados