Contribution to the Preclinical Safety Assessment of Lannea velutina and Sorindeia juglandifolia Leaves
| Autor(a) principal: | |
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| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/150806 |
Resumo: | Funding Information: This research was funded by the Foundation for Science and Technology (FCT, Portugal) through national funds FCT/MCTES to iMed.ULisboa (UIDP/04138/2020), cE3c (UIDB/00329/2020), MEtRICs (UIDP/04077/2020, UIDPB/04077/2020), and to Faculdade de Ciências da Universidade de Lisboa project PTDC/AFR/117785/2010. Publisher Copyright: © 2022 by the authors. |
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Contribution to the Preclinical Safety Assessment of Lannea velutina and Sorindeia juglandifolia LeavesAmes testgenotoxicityLannea velutinarepeated-dose oral toxicitySorindeia juglandifoliaEcology, Evolution, Behavior and SystematicsEcologyPlant ScienceFunding Information: This research was funded by the Foundation for Science and Technology (FCT, Portugal) through national funds FCT/MCTES to iMed.ULisboa (UIDP/04138/2020), cE3c (UIDB/00329/2020), MEtRICs (UIDP/04077/2020, UIDPB/04077/2020), and to Faculdade de Ciências da Universidade de Lisboa project PTDC/AFR/117785/2010. Publisher Copyright: © 2022 by the authors.Dried leaves of Lannea velutina A. Rich. and Sorindeia juglandifolia (A. Rich.) Planch. ex Oliv. (family Anacardiaceae) are used in African traditional medicine. Although these medicinal plants have widespread use in the treatment of inflammatory diseases, there is no scientific data concerning their preclinical or clinical safety. This work aimed to investigate the phytochemical properties of the leaves of both species using HPLC-UV/DAD, as well as the in vivo oral repeated-dose toxicity of 70% hydroethanolic leaf extract of S. juglandifolia and the in vitro genotoxicity of 70% hydroethanolic leaf extracts of L. velutina and S. juglandifolia. Clinical signs of toxicity, body weight variations, and changes in food consumption, mortality, and blood biochemical parameters were monitored. Genotoxicity was assessed using the bacterial reverse mutation assay (Ames test) with and without metabolic activation, according to OECD guidelines. The obtained results showed the presence of gallic acid and anacardic acid as the main marker constituents in both species. No significant changes in general body weight or food intake were observed; small significant changes with no critical relevance were observed in the blood biochemistry of animals treated with S. juglandifolia hydroethanolic extract (50, 400, and 1000 mg/kg body weight) compared to those in the control group. No genotoxicity was observed in the bacterial reverse mutation assay with S. juglandifolia and L. velutina extracts (up to 5 mg/plate). The safety data obtained in vivo and lack of genotoxic potential in vitro points to the safe medicinal use of S. juglandifolia and L. velutina extracts.DQ - Departamento de QuímicaMEtRICS - Centro de Engenharia Mecânica e Sustentabilidade de RecursosRUNMalú, QuintinoLima, KateleneMalmir, MaryamPinto, Ruida Silva, Isabel MoreiraCatarino, LuísDuarte, Maria PaulaSerrano, RitaRocha, JoãoLima, Beatriz SilvaSilva, Olga2023-03-17T22:32:04Z2022-12-272022-12-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article15application/pdfhttp://hdl.handle.net/10362/150806engMalú, Q., Lima, K., Malmir, M., Pinto, R., da Silva, I. M., Catarino, L., Duarte, M. P., Serrano, R., Rocha, J., Lima, B. S., & Silva, O. (2022). Contribution to the Preclinical Safety Assessment of Lannea velutina and Sorindeia juglandifolia Leaves. Plants, 12(1), [130]. https://doi.org/10.3390/plants120101302223-7747PURE: 56246576https://doi.org/10.3390/plants12010130info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-10T16:12:59ZPortal AgregadorONG |
| dc.title.none.fl_str_mv |
Contribution to the Preclinical Safety Assessment of Lannea velutina and Sorindeia juglandifolia Leaves |
| title |
Contribution to the Preclinical Safety Assessment of Lannea velutina and Sorindeia juglandifolia Leaves |
| spellingShingle |
Contribution to the Preclinical Safety Assessment of Lannea velutina and Sorindeia juglandifolia Leaves Malú, Quintino Ames test genotoxicity Lannea velutina repeated-dose oral toxicity Sorindeia juglandifolia Ecology, Evolution, Behavior and Systematics Ecology Plant Science |
| title_short |
Contribution to the Preclinical Safety Assessment of Lannea velutina and Sorindeia juglandifolia Leaves |
| title_full |
Contribution to the Preclinical Safety Assessment of Lannea velutina and Sorindeia juglandifolia Leaves |
| title_fullStr |
Contribution to the Preclinical Safety Assessment of Lannea velutina and Sorindeia juglandifolia Leaves |
| title_full_unstemmed |
Contribution to the Preclinical Safety Assessment of Lannea velutina and Sorindeia juglandifolia Leaves |
| title_sort |
Contribution to the Preclinical Safety Assessment of Lannea velutina and Sorindeia juglandifolia Leaves |
| author |
Malú, Quintino |
| author_facet |
Malú, Quintino Lima, Katelene Malmir, Maryam Pinto, Rui da Silva, Isabel Moreira Catarino, Luís Duarte, Maria Paula Serrano, Rita Rocha, João Lima, Beatriz Silva Silva, Olga |
| author_role |
author |
| author2 |
Lima, Katelene Malmir, Maryam Pinto, Rui da Silva, Isabel Moreira Catarino, Luís Duarte, Maria Paula Serrano, Rita Rocha, João Lima, Beatriz Silva Silva, Olga |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
DQ - Departamento de Química MEtRICS - Centro de Engenharia Mecânica e Sustentabilidade de Recursos RUN |
| dc.contributor.author.fl_str_mv |
Malú, Quintino Lima, Katelene Malmir, Maryam Pinto, Rui da Silva, Isabel Moreira Catarino, Luís Duarte, Maria Paula Serrano, Rita Rocha, João Lima, Beatriz Silva Silva, Olga |
| dc.subject.por.fl_str_mv |
Ames test genotoxicity Lannea velutina repeated-dose oral toxicity Sorindeia juglandifolia Ecology, Evolution, Behavior and Systematics Ecology Plant Science |
| topic |
Ames test genotoxicity Lannea velutina repeated-dose oral toxicity Sorindeia juglandifolia Ecology, Evolution, Behavior and Systematics Ecology Plant Science |
| description |
Funding Information: This research was funded by the Foundation for Science and Technology (FCT, Portugal) through national funds FCT/MCTES to iMed.ULisboa (UIDP/04138/2020), cE3c (UIDB/00329/2020), MEtRICs (UIDP/04077/2020, UIDPB/04077/2020), and to Faculdade de Ciências da Universidade de Lisboa project PTDC/AFR/117785/2010. Publisher Copyright: © 2022 by the authors. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-12-27 2022-12-27T00:00:00Z 2023-03-17T22:32:04Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/150806 |
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http://hdl.handle.net/10362/150806 |
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eng |
| language |
eng |
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Malú, Q., Lima, K., Malmir, M., Pinto, R., da Silva, I. M., Catarino, L., Duarte, M. P., Serrano, R., Rocha, J., Lima, B. S., & Silva, O. (2022). Contribution to the Preclinical Safety Assessment of Lannea velutina and Sorindeia juglandifolia Leaves. Plants, 12(1), [130]. https://doi.org/10.3390/plants12010130 2223-7747 PURE: 56246576 https://doi.org/10.3390/plants12010130 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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15 application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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