Origin and Epidemiological History of HIV-1 CRF14_BG

Detalhes bibliográficos
Autor(a) principal: Bártolo, Inês
Data de Publicação: 2011
Outros Autores: AB, Abecasis, Borrego, Pedro, Barroso, Helena, McCutchan, Francine, Gomes, Perpétua, Camacho, Ricardo, Taveira, Nuno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.26/4991
Resumo: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Users must also make clear the license terms under which the work was published. CC BY Licence: http://creativecommons.org/licenses/by/4.0/
id RCAP_48bccd8a87f5615b60ff8b6232afe1eb
oai_identifier_str oai:comum.rcaap.pt:10400.26/4991
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Origin and Epidemiological History of HIV-1 CRF14_BGHIV-1CRF14_BGCXCR4 tropismThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Users must also make clear the license terms under which the work was published. CC BY Licence: http://creativecommons.org/licenses/by/4.0/Background: CRF14_BG isolates, originally found in Spain, are characterized by CXCR4 tropism and rapid disease progression. This study aimed to identify the origin of CRF14_BG and reconstruct its epidemiological history based on new isolates from Portugal.Methodology/Principal Findings: C2V3C3 env gene sequences were obtained from 62 samples collected in 1993–1998 from Portuguese HIV-1 patients. Full-length genomic sequences were obtained from three patients. Viral subtypes, diversity, divergence rate and positive selection were investigated by phylogenetic analysis. The molecular structure of the genomes was determined by bootscanning. A relaxed molecular clock model was used to date the origin of CRF14_BG. Geno2pheno was used to predict viral tropism. Subtype B was the most prevalent subtype (45 sequences; 73%) followed by CRF14_BG (8; 13%), G (4; 6%), F1 (2; 3%), C (2; 3%) and CRF02_AG (1; 2%). Three CRF14_BG sequences were derived from 1993 samples. Near full-length genomic sequences were strongly related to the CRF14_BG isolates from Spain. Genetic diversity of the Portuguese isolates was significantly higher than the Spanish isolates (0.044 vs 0.014, P,0.0001). The mean date of origin of the CRF14_BG cluster was estimated to be 1992 (range, 1989 and 1996) based on the subtype G genomic region and 1989 (range, 1984–1993) based on the subtype B genomic region. Most CRF14_BG strains (78.9%) were predicted to be CXCR4. Finally, up to five amino acids were under selective pressure in subtype B V3 loop whereas only one was found in the CRF14_BG cluster.Conclusions: CRF14_BG emerged in Portugal in the early 1990 s soon after the beginning of the HIV-1 epidemics, spread to Spain in late 1990 s as a consequence of IVDUs migration and then to the rest of Europe. CXCR4 tropism is a general characteristic of this CRF that may have been selected for by escape from neutralizing antibody response.PLOSRepositório ComumBártolo, InêsAB, AbecasisBorrego, PedroBarroso, HelenaMcCutchan, FrancineGomes, PerpétuaCamacho, RicardoTaveira, Nuno2013-11-29T12:16:40Z2011-092011-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/4991engBártolo I, Abecasis AB, Borrego P, Barroso H, McCutchan F, et al. (2011) Origin and Epidemiological History of HIV-1 CRF14_BG. PLoS ONE 6(9): e24130. doi:10.1371/journal.pone.00241301932-6203info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T02:30:51Zoai:comum.rcaap.pt:10400.26/4991Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:06:01.351570Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Origin and Epidemiological History of HIV-1 CRF14_BG
title Origin and Epidemiological History of HIV-1 CRF14_BG
spellingShingle Origin and Epidemiological History of HIV-1 CRF14_BG
Bártolo, Inês
HIV-1
CRF14_BG
CXCR4 tropism
title_short Origin and Epidemiological History of HIV-1 CRF14_BG
title_full Origin and Epidemiological History of HIV-1 CRF14_BG
title_fullStr Origin and Epidemiological History of HIV-1 CRF14_BG
title_full_unstemmed Origin and Epidemiological History of HIV-1 CRF14_BG
title_sort Origin and Epidemiological History of HIV-1 CRF14_BG
author Bártolo, Inês
author_facet Bártolo, Inês
AB, Abecasis
Borrego, Pedro
Barroso, Helena
McCutchan, Francine
Gomes, Perpétua
Camacho, Ricardo
Taveira, Nuno
author_role author
author2 AB, Abecasis
Borrego, Pedro
Barroso, Helena
McCutchan, Francine
Gomes, Perpétua
Camacho, Ricardo
Taveira, Nuno
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Bártolo, Inês
AB, Abecasis
Borrego, Pedro
Barroso, Helena
McCutchan, Francine
Gomes, Perpétua
Camacho, Ricardo
Taveira, Nuno
dc.subject.por.fl_str_mv HIV-1
CRF14_BG
CXCR4 tropism
topic HIV-1
CRF14_BG
CXCR4 tropism
description This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Users must also make clear the license terms under which the work was published. CC BY Licence: http://creativecommons.org/licenses/by/4.0/
publishDate 2011
dc.date.none.fl_str_mv 2011-09
2011-09-01T00:00:00Z
2013-11-29T12:16:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/4991
url http://hdl.handle.net/10400.26/4991
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Bártolo I, Abecasis AB, Borrego P, Barroso H, McCutchan F, et al. (2011) Origin and Epidemiological History of HIV-1 CRF14_BG. PLoS ONE 6(9): e24130. doi:10.1371/journal.pone.0024130
1932-6203
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv PLOS
publisher.none.fl_str_mv PLOS
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799129931338219520

Registros relacionados