Microglial Sirtuin 2 shapes long-term potentiation in hippocampal slices

Detalhes bibliográficos
Autor(a) principal: Sa de Almeida, Joana
Data de Publicação: 2020
Outros Autores: Vargas, Mariana, Fonseca-Gomes, João, Tanqueiro, Sara, Belo, Rita F., Miranda-Lourenço, Catarina, Sebastião, Ana M, Diógenes, Maria José, Pais, Teresa F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/55347
Resumo: Copyright © 2020 Sa de Almeida, Vargas, Fonseca-Gomes, Tanqueiro, Belo, Miranda-Lourenço, Sebastião, Diógenes and Pais. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling Microglial Sirtuin 2 shapes long-term potentiation in hippocampal slicesLong-term potentiationMemantineMicrogliaNeuroinfalmmationSirtuin 2Copyright © 2020 Sa de Almeida, Vargas, Fonseca-Gomes, Tanqueiro, Belo, Miranda-Lourenço, Sebastião, Diógenes and Pais. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Microglial cells have emerged as crucial players in synaptic plasticity during development and adulthood, and also in neurodegenerative and neuroinflammatory conditions. Here we found that decreased levels of Sirtuin 2 (Sirt2) deacetylase in microglia affects hippocampal synaptic plasticity under inflammatory conditions. The results show that long-term potentiation (LTP) magnitude recorded from hippocampal slices of wild type mice does not differ between those exposed to lipopolysaccharide (LPS), a pro-inflammatory stimulus, or BSA. However, LTP recorded from hippocampal slices of microglial-specific Sirt2 deficient (Sirt2-) mice was significantly impaired by LPS. Importantly, LTP values were restored by memantine, an antagonist of N-methyl-D-aspartate (NMDA) receptors. These results indicate that microglial Sirt2 prevents NMDA-mediated excitotoxicity in hippocampal slices in response to an inflammatory signal such as LPS. Overall, our data suggest a key-protective role for microglial Sirt2 in mnesic deficits associated with neuroinflammation.This study was supported by Santa Casa da Misericórdia de Lisboa (MB37-2017), GAPIC Research Program of the University of Lisbon Medical School (n° 2014002 and n° 2015028) and the following doctoral grants: PD/BD/128091/2016, SFRH/BD/118238/2016, PD/BD/114337/2016, and PD/BD/1144- 41/2016.FrontiersRepositório da Universidade de LisboaSa de Almeida, JoanaVargas, MarianaFonseca-Gomes, JoãoTanqueiro, SaraBelo, Rita F.Miranda-Lourenço, CatarinaSebastião, Ana MDiógenes, Maria JoséPais, Teresa F.2022-12-06T12:21:18Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/55347engFront Neurosci. 2020 Jun 18;14:6141662-454810.3389/fnins.2020.006141662-453Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:02:12Zoai:repositorio.ul.pt:10451/55347Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:05:59.878506Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Microglial Sirtuin 2 shapes long-term potentiation in hippocampal slices
title Microglial Sirtuin 2 shapes long-term potentiation in hippocampal slices
spellingShingle Microglial Sirtuin 2 shapes long-term potentiation in hippocampal slices
Sa de Almeida, Joana
Long-term potentiation
Memantine
Microglia
Neuroinfalmmation
Sirtuin 2
title_short Microglial Sirtuin 2 shapes long-term potentiation in hippocampal slices
title_full Microglial Sirtuin 2 shapes long-term potentiation in hippocampal slices
title_fullStr Microglial Sirtuin 2 shapes long-term potentiation in hippocampal slices
title_full_unstemmed Microglial Sirtuin 2 shapes long-term potentiation in hippocampal slices
title_sort Microglial Sirtuin 2 shapes long-term potentiation in hippocampal slices
author Sa de Almeida, Joana
author_facet Sa de Almeida, Joana
Vargas, Mariana
Fonseca-Gomes, João
Tanqueiro, Sara
Belo, Rita F.
Miranda-Lourenço, Catarina
Sebastião, Ana M
Diógenes, Maria José
Pais, Teresa F.
author_role author
author2 Vargas, Mariana
Fonseca-Gomes, João
Tanqueiro, Sara
Belo, Rita F.
Miranda-Lourenço, Catarina
Sebastião, Ana M
Diógenes, Maria José
Pais, Teresa F.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Sa de Almeida, Joana
Vargas, Mariana
Fonseca-Gomes, João
Tanqueiro, Sara
Belo, Rita F.
Miranda-Lourenço, Catarina
Sebastião, Ana M
Diógenes, Maria José
Pais, Teresa F.
dc.subject.por.fl_str_mv Long-term potentiation
Memantine
Microglia
Neuroinfalmmation
Sirtuin 2
topic Long-term potentiation
Memantine
Microglia
Neuroinfalmmation
Sirtuin 2
description Copyright © 2020 Sa de Almeida, Vargas, Fonseca-Gomes, Tanqueiro, Belo, Miranda-Lourenço, Sebastião, Diógenes and Pais. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
2022-12-06T12:21:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/55347
url http://hdl.handle.net/10451/55347
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front Neurosci. 2020 Jun 18;14:614
1662-4548
10.3389/fnins.2020.00614
1662-453X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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