Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosis
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/40216 |
Resumo: | Invasive aspergillosis (IA) is a life-threatening fungal disease commonly diagnosed among individuals with immunological deficits, namely hematological patients undergoing chemotherapy or allogeneic hematopoietic stem cell transplantation. Vaccines are not available, and despite the improved diagnosis and antifungal therapy, the treatment of IA is associated with a poor outcome. Importantly, the risk of infection and its clinical outcome vary significantly even among patients with similar predisposing clinical factors and microbiological exposure. Recent insights into antifungal immunity have further highlighted the complexity of host-fungus interactions and the multiple pathogen-sensing systems activated to control infection. How to decode this information into clinical practice remains however, a challenging issue in medical mycology. Here, we address recent advances in our understanding of the host-fungus interaction and discuss the application of this knowledge in potential strategies with the aim of moving toward personalized diagnostics and treatment (theranostics) in immunocompromised patients. Ultimately, the integration of individual traits into a clinically applicable process to predict the risk and progression of disease, and the efficacy of antifungal prophylaxis and therapy, holds the promise of a pioneering innovation benefiting patients at risk of IA. |
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Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosisInvasive aspergillosisStem cell transplantationAntifungal immunitySingle nucleotide polymorphismPersonalized medicineScience & TechnologyInvasive aspergillosis (IA) is a life-threatening fungal disease commonly diagnosed among individuals with immunological deficits, namely hematological patients undergoing chemotherapy or allogeneic hematopoietic stem cell transplantation. Vaccines are not available, and despite the improved diagnosis and antifungal therapy, the treatment of IA is associated with a poor outcome. Importantly, the risk of infection and its clinical outcome vary significantly even among patients with similar predisposing clinical factors and microbiological exposure. Recent insights into antifungal immunity have further highlighted the complexity of host-fungus interactions and the multiple pathogen-sensing systems activated to control infection. How to decode this information into clinical practice remains however, a challenging issue in medical mycology. Here, we address recent advances in our understanding of the host-fungus interaction and discuss the application of this knowledge in potential strategies with the aim of moving toward personalized diagnostics and treatment (theranostics) in immunocompromised patients. Ultimately, the integration of individual traits into a clinically applicable process to predict the risk and progression of disease, and the efficacy of antifungal prophylaxis and therapy, holds the promise of a pioneering innovation benefiting patients at risk of IA.CC is supported by the Fundação para a Ciência e Tecnologia, Portugal (SFRH/BPD/96176/2013)Frontiers MediaUniversidade do MinhoCoelho, Ana OliveiraRodrigues, Fernando José dos SantosCampos Junior, AntónioLacerda, João F.Carvalho, AgostinhoCunha, Cristina20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/40216engOliveira-Coelho, A., Rodrigues, F., Campos, A., Jr., Lacerda, J. F., Carvalho, A., & Cunha, C. (2015). Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosis. Frontiers in Microbiology, 6. doi: 10.3389/fmicb.2015.004111664-302X10.3389/fmicb.2015.00411http://journal.frontiersin.org/article/10.3389/fmicb.2015.00411/abstractinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:25:18Zoai:repositorium.sdum.uminho.pt:1822/40216Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:19:31.056842Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosis |
title |
Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosis |
spellingShingle |
Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosis Coelho, Ana Oliveira Invasive aspergillosis Stem cell transplantation Antifungal immunity Single nucleotide polymorphism Personalized medicine Science & Technology |
title_short |
Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosis |
title_full |
Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosis |
title_fullStr |
Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosis |
title_full_unstemmed |
Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosis |
title_sort |
Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosis |
author |
Coelho, Ana Oliveira |
author_facet |
Coelho, Ana Oliveira Rodrigues, Fernando José dos Santos Campos Junior, António Lacerda, João F. Carvalho, Agostinho Cunha, Cristina |
author_role |
author |
author2 |
Rodrigues, Fernando José dos Santos Campos Junior, António Lacerda, João F. Carvalho, Agostinho Cunha, Cristina |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Coelho, Ana Oliveira Rodrigues, Fernando José dos Santos Campos Junior, António Lacerda, João F. Carvalho, Agostinho Cunha, Cristina |
dc.subject.por.fl_str_mv |
Invasive aspergillosis Stem cell transplantation Antifungal immunity Single nucleotide polymorphism Personalized medicine Science & Technology |
topic |
Invasive aspergillosis Stem cell transplantation Antifungal immunity Single nucleotide polymorphism Personalized medicine Science & Technology |
description |
Invasive aspergillosis (IA) is a life-threatening fungal disease commonly diagnosed among individuals with immunological deficits, namely hematological patients undergoing chemotherapy or allogeneic hematopoietic stem cell transplantation. Vaccines are not available, and despite the improved diagnosis and antifungal therapy, the treatment of IA is associated with a poor outcome. Importantly, the risk of infection and its clinical outcome vary significantly even among patients with similar predisposing clinical factors and microbiological exposure. Recent insights into antifungal immunity have further highlighted the complexity of host-fungus interactions and the multiple pathogen-sensing systems activated to control infection. How to decode this information into clinical practice remains however, a challenging issue in medical mycology. Here, we address recent advances in our understanding of the host-fungus interaction and discuss the application of this knowledge in potential strategies with the aim of moving toward personalized diagnostics and treatment (theranostics) in immunocompromised patients. Ultimately, the integration of individual traits into a clinically applicable process to predict the risk and progression of disease, and the efficacy of antifungal prophylaxis and therapy, holds the promise of a pioneering innovation benefiting patients at risk of IA. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 2015-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/40216 |
url |
http://hdl.handle.net/1822/40216 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Oliveira-Coelho, A., Rodrigues, F., Campos, A., Jr., Lacerda, J. F., Carvalho, A., & Cunha, C. (2015). Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosis. Frontiers in Microbiology, 6. doi: 10.3389/fmicb.2015.00411 1664-302X 10.3389/fmicb.2015.00411 http://journal.frontiersin.org/article/10.3389/fmicb.2015.00411/abstract |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132654883307520 |