Time-to-treatment initiation of colchicine and cardiovascular outcomes after myocardial infarction in the Colchicine Cardiovascular Outcomes Trial (COLCOT)
| Autor(a) principal: | |
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| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/44341 |
Resumo: | © The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
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Time-to-treatment initiation of colchicine and cardiovascular outcomes after myocardial infarction in the Colchicine Cardiovascular Outcomes Trial (COLCOT)Cardiovascular inflammationTime-to-treatment initiationColchicineCOLCOTInflammasome© The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.comAims: The COLchicine Cardiovascular Outcomes Trial (COLCOT) demonstrated the benefits of targeting inflammation after myocardial infarction (MI). We aimed to determine whether time-to-treatment initiation (TTI) influences the beneficial impact of colchicine. Methods and results: In COLCOT, patients were randomly assigned to receive colchicine or placebo within 30 days post-MI. Time-to-treatment initiation was defined as the length of time between the index MI and the initiation of study medication. The primary efficacy endpoint was a composite of cardiovascular death, resuscitated cardiac arrest, MI, stroke, or urgent hospitalization for angina requiring coronary revascularization. The relationship between endpoints and various TTI (<3, 4–7 and >8 days) was examined using multivariable Cox regression models. Amongst the 4661 patients included in this analysis, there were 1193, 720, and 2748 patients, respectively, in the three TTI strata. After a median follow-up of 22.7 months, there was a significant reduction in the incidence of the primary endpoint for patients in whom colchicine was initiated < Day 3 compared with placebo [hazard ratios (HR) = 0.52, 95% confidence intervals (CI) 0.32–0.84], in contrast to patients in whom colchicine was initiated between Days 4 and 7 (HR = 0.96, 95% CI 0.53–1.75) or > Day 8 (HR = 0.82, 95% CI 0.61–1.11). The beneficial effects of early initiation of colchicine were also demonstrated for urgent hospitalization for angina requiring revascularization (HR = 0.35), all coronary revascularization (HR = 0.63), and the composite of cardiovascular death, resuscitated cardiac arrest, MI, or stroke (HR = 0.55, all P < 0.05). Conclusion: Patients benefit from early, in-hospital initiation of colchicine after MI.The COLCOT trial was supported by the Government of Quebec, the Canadian Institutes of Health Research, the Montreal Heart Institute Foundation and other philanthropic foundations. The funding sources had no role in study design, conduct, or analyses.Oxford University PressRepositório da Universidade de LisboaBouabdallaoui, NadiaTardif, Jean-ClaudeWaters, David D.Pinto, Fausto J.Maggioni, Aldo P.Diaz, RafaelBerry, ColinKoenig, WolfgangLopez-Sendon, JoseGamra, HabibKiwan, Ghassan S.Blondeau, LucieOrfanos, AndreasIbrahim, RedaGrégoire, Jean C.Dubé, Marie-PierreSamuel, MichelleMorel, OlivierLim, PascalBertrand, Olivier F.Kouz, SimonGuertin, Marie-ClaudeL'Allier, Philippe L.Roubille, François2020-09-10T15:41:57Z2020-08-292020-08-29T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/44341engEuropean Heart Journal, 29 August 20200195-668X10.1093/eurheartj/ehaa6591522-9645info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:45:21Zoai:repositorio.ul.pt:10451/44341Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:56:57.091525Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Time-to-treatment initiation of colchicine and cardiovascular outcomes after myocardial infarction in the Colchicine Cardiovascular Outcomes Trial (COLCOT) |
| title |
Time-to-treatment initiation of colchicine and cardiovascular outcomes after myocardial infarction in the Colchicine Cardiovascular Outcomes Trial (COLCOT) |
| spellingShingle |
Time-to-treatment initiation of colchicine and cardiovascular outcomes after myocardial infarction in the Colchicine Cardiovascular Outcomes Trial (COLCOT) Bouabdallaoui, Nadia Cardiovascular inflammation Time-to-treatment initiation Colchicine COLCOT Inflammasome |
| title_short |
Time-to-treatment initiation of colchicine and cardiovascular outcomes after myocardial infarction in the Colchicine Cardiovascular Outcomes Trial (COLCOT) |
| title_full |
Time-to-treatment initiation of colchicine and cardiovascular outcomes after myocardial infarction in the Colchicine Cardiovascular Outcomes Trial (COLCOT) |
| title_fullStr |
Time-to-treatment initiation of colchicine and cardiovascular outcomes after myocardial infarction in the Colchicine Cardiovascular Outcomes Trial (COLCOT) |
| title_full_unstemmed |
Time-to-treatment initiation of colchicine and cardiovascular outcomes after myocardial infarction in the Colchicine Cardiovascular Outcomes Trial (COLCOT) |
| title_sort |
Time-to-treatment initiation of colchicine and cardiovascular outcomes after myocardial infarction in the Colchicine Cardiovascular Outcomes Trial (COLCOT) |
| author |
Bouabdallaoui, Nadia |
| author_facet |
Bouabdallaoui, Nadia Tardif, Jean-Claude Waters, David D. Pinto, Fausto J. Maggioni, Aldo P. Diaz, Rafael Berry, Colin Koenig, Wolfgang Lopez-Sendon, Jose Gamra, Habib Kiwan, Ghassan S. Blondeau, Lucie Orfanos, Andreas Ibrahim, Reda Grégoire, Jean C. Dubé, Marie-Pierre Samuel, Michelle Morel, Olivier Lim, Pascal Bertrand, Olivier F. Kouz, Simon Guertin, Marie-Claude L'Allier, Philippe L. Roubille, François |
| author_role |
author |
| author2 |
Tardif, Jean-Claude Waters, David D. Pinto, Fausto J. Maggioni, Aldo P. Diaz, Rafael Berry, Colin Koenig, Wolfgang Lopez-Sendon, Jose Gamra, Habib Kiwan, Ghassan S. Blondeau, Lucie Orfanos, Andreas Ibrahim, Reda Grégoire, Jean C. Dubé, Marie-Pierre Samuel, Michelle Morel, Olivier Lim, Pascal Bertrand, Olivier F. Kouz, Simon Guertin, Marie-Claude L'Allier, Philippe L. Roubille, François |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Bouabdallaoui, Nadia Tardif, Jean-Claude Waters, David D. Pinto, Fausto J. Maggioni, Aldo P. Diaz, Rafael Berry, Colin Koenig, Wolfgang Lopez-Sendon, Jose Gamra, Habib Kiwan, Ghassan S. Blondeau, Lucie Orfanos, Andreas Ibrahim, Reda Grégoire, Jean C. Dubé, Marie-Pierre Samuel, Michelle Morel, Olivier Lim, Pascal Bertrand, Olivier F. Kouz, Simon Guertin, Marie-Claude L'Allier, Philippe L. Roubille, François |
| dc.subject.por.fl_str_mv |
Cardiovascular inflammation Time-to-treatment initiation Colchicine COLCOT Inflammasome |
| topic |
Cardiovascular inflammation Time-to-treatment initiation Colchicine COLCOT Inflammasome |
| description |
© The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-09-10T15:41:57Z 2020-08-29 2020-08-29T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/44341 |
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http://hdl.handle.net/10451/44341 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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European Heart Journal, 29 August 2020 0195-668X 10.1093/eurheartj/ehaa659 1522-9645 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Oxford University Press |
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Oxford University Press |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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