In vitro assessment of oral and respiratory bioaccesibility of trace elements of environmental concern in Greek fly ashes: assessing health risk via ingestion and inhalation
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/37306 |
Resumo: | Fly ash engender significant environmental and human health problems due to enhanced contents of potentially harmful trace elements (TrElems). This study aims to evaluate human exposure to TrElems via a combined ingestion (i.e., oral bioaccessibility) and inhalation (i.e., respiratory bioaccessibility) pathway. Five fly ash samples were collected from power plants operating in the main lignite basins of Greece, while the ingestible (<250 μm) and inhalable (<10 μm) particle size fractions were utilized. The Unified Bioaccessibility Method (UBM) was utilized to assess the oral bioaccessibility, while the respiratory bioaccessible fractions were extracted using the Artificial Lysosomal Fluid (ALF). All studied FAs exhibited significantly higher contents in Ba, Cr, Ni, V and Zn. Cadmium was presented relative enriched in the finer size fraction (<10 μm), while Ba, Co, Cr, Cu, Mn, Ni and V were depleted. The UBM-extractable concentrations fluctuated greatly among the studied FAs, while notably lower bioaccessible contents were recorded in the gastrointestinal phase. On the other hand, ALF-extractable concentrations were surprisingly higher than the corresponding UBM-extractable ones in the gastric phase. The oral bioaccessibility of the studied TrElems ranged from 12.5 to 100%, while respiratory bioaccessibility presented high values exceeding 45% on average. A significant effect of fly ash type on human bioaccessibility was revealed. Thus, high-Ca FAs exhibited significantly higher bioaccessibility of the studied TrElems via ingestion, while a relatively higher bioaccessibility via inhalation was observed for high-Si FAs. Regarding non-carcinogenic health risk via ingestion and inhalation, Cr and Co exhibited the highest HQing and HQinh values, however there were significantly lower than safe level (HQ < 1). On the contrary, Cr was the dominant contributor to carcinogenic risk with CR values being well above threshold or even tolerable risk levels. |
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In vitro assessment of oral and respiratory bioaccesibility of trace elements of environmental concern in Greek fly ashes: assessing health risk via ingestion and inhalationHuman bioaccessibilityFly ashTrace elementHealth riskCancer riskFly ash engender significant environmental and human health problems due to enhanced contents of potentially harmful trace elements (TrElems). This study aims to evaluate human exposure to TrElems via a combined ingestion (i.e., oral bioaccessibility) and inhalation (i.e., respiratory bioaccessibility) pathway. Five fly ash samples were collected from power plants operating in the main lignite basins of Greece, while the ingestible (<250 μm) and inhalable (<10 μm) particle size fractions were utilized. The Unified Bioaccessibility Method (UBM) was utilized to assess the oral bioaccessibility, while the respiratory bioaccessible fractions were extracted using the Artificial Lysosomal Fluid (ALF). All studied FAs exhibited significantly higher contents in Ba, Cr, Ni, V and Zn. Cadmium was presented relative enriched in the finer size fraction (<10 μm), while Ba, Co, Cr, Cu, Mn, Ni and V were depleted. The UBM-extractable concentrations fluctuated greatly among the studied FAs, while notably lower bioaccessible contents were recorded in the gastrointestinal phase. On the other hand, ALF-extractable concentrations were surprisingly higher than the corresponding UBM-extractable ones in the gastric phase. The oral bioaccessibility of the studied TrElems ranged from 12.5 to 100%, while respiratory bioaccessibility presented high values exceeding 45% on average. A significant effect of fly ash type on human bioaccessibility was revealed. Thus, high-Ca FAs exhibited significantly higher bioaccessibility of the studied TrElems via ingestion, while a relatively higher bioaccessibility via inhalation was observed for high-Si FAs. Regarding non-carcinogenic health risk via ingestion and inhalation, Cr and Co exhibited the highest HQing and HQinh values, however there were significantly lower than safe level (HQ < 1). On the contrary, Cr was the dominant contributor to carcinogenic risk with CR values being well above threshold or even tolerable risk levels.Elsevier2023-04-24T10:24:24Z2020-02-20T00:00:00Z2020-02-20info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/37306eng0048-969710.1016/j.scitotenv.2019.135324Bourliva, AnnaPapadopoulou, Lambrinida Silva, Eduardo FerreiraPatinha, Carlainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-17T04:19:20ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
In vitro assessment of oral and respiratory bioaccesibility of trace elements of environmental concern in Greek fly ashes: assessing health risk via ingestion and inhalation |
title |
In vitro assessment of oral and respiratory bioaccesibility of trace elements of environmental concern in Greek fly ashes: assessing health risk via ingestion and inhalation |
spellingShingle |
In vitro assessment of oral and respiratory bioaccesibility of trace elements of environmental concern in Greek fly ashes: assessing health risk via ingestion and inhalation Bourliva, Anna Human bioaccessibility Fly ash Trace element Health risk Cancer risk |
title_short |
In vitro assessment of oral and respiratory bioaccesibility of trace elements of environmental concern in Greek fly ashes: assessing health risk via ingestion and inhalation |
title_full |
In vitro assessment of oral and respiratory bioaccesibility of trace elements of environmental concern in Greek fly ashes: assessing health risk via ingestion and inhalation |
title_fullStr |
In vitro assessment of oral and respiratory bioaccesibility of trace elements of environmental concern in Greek fly ashes: assessing health risk via ingestion and inhalation |
title_full_unstemmed |
In vitro assessment of oral and respiratory bioaccesibility of trace elements of environmental concern in Greek fly ashes: assessing health risk via ingestion and inhalation |
title_sort |
In vitro assessment of oral and respiratory bioaccesibility of trace elements of environmental concern in Greek fly ashes: assessing health risk via ingestion and inhalation |
author |
Bourliva, Anna |
author_facet |
Bourliva, Anna Papadopoulou, Lambrini da Silva, Eduardo Ferreira Patinha, Carla |
author_role |
author |
author2 |
Papadopoulou, Lambrini da Silva, Eduardo Ferreira Patinha, Carla |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Bourliva, Anna Papadopoulou, Lambrini da Silva, Eduardo Ferreira Patinha, Carla |
dc.subject.por.fl_str_mv |
Human bioaccessibility Fly ash Trace element Health risk Cancer risk |
topic |
Human bioaccessibility Fly ash Trace element Health risk Cancer risk |
description |
Fly ash engender significant environmental and human health problems due to enhanced contents of potentially harmful trace elements (TrElems). This study aims to evaluate human exposure to TrElems via a combined ingestion (i.e., oral bioaccessibility) and inhalation (i.e., respiratory bioaccessibility) pathway. Five fly ash samples were collected from power plants operating in the main lignite basins of Greece, while the ingestible (<250 μm) and inhalable (<10 μm) particle size fractions were utilized. The Unified Bioaccessibility Method (UBM) was utilized to assess the oral bioaccessibility, while the respiratory bioaccessible fractions were extracted using the Artificial Lysosomal Fluid (ALF). All studied FAs exhibited significantly higher contents in Ba, Cr, Ni, V and Zn. Cadmium was presented relative enriched in the finer size fraction (<10 μm), while Ba, Co, Cr, Cu, Mn, Ni and V were depleted. The UBM-extractable concentrations fluctuated greatly among the studied FAs, while notably lower bioaccessible contents were recorded in the gastrointestinal phase. On the other hand, ALF-extractable concentrations were surprisingly higher than the corresponding UBM-extractable ones in the gastric phase. The oral bioaccessibility of the studied TrElems ranged from 12.5 to 100%, while respiratory bioaccessibility presented high values exceeding 45% on average. A significant effect of fly ash type on human bioaccessibility was revealed. Thus, high-Ca FAs exhibited significantly higher bioaccessibility of the studied TrElems via ingestion, while a relatively higher bioaccessibility via inhalation was observed for high-Si FAs. Regarding non-carcinogenic health risk via ingestion and inhalation, Cr and Co exhibited the highest HQing and HQinh values, however there were significantly lower than safe level (HQ < 1). On the contrary, Cr was the dominant contributor to carcinogenic risk with CR values being well above threshold or even tolerable risk levels. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-02-20T00:00:00Z 2020-02-20 2023-04-24T10:24:24Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/37306 |
url |
http://hdl.handle.net/10773/37306 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0048-9697 10.1016/j.scitotenv.2019.135324 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
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repository.mail.fl_str_mv |
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1777303598562017280 |