Strontium Doped Bioactive Glass Nanoparticles in Osteogenic Commitment

Detalhes bibliográficos
Autor(a) principal: Leite, A. J.
Data de Publicação: 2018
Outros Autores: Gonçalves, A I, Rodrigues, M. T., Gomes, Manuela E., Mano, J. F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/58749
Resumo: “Just Accepted” manuscript
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spelling Strontium Doped Bioactive Glass Nanoparticles in Osteogenic CommitmenthASCsosteogenic differentiationStrontiumnanoparticlesbioactivityosteogenic commitmentsol-gelsolâgelCiências Médicas::Biotecnologia MédicaEngenharia e Tecnologia::Biotecnologia IndustrialScience & Technology“Just Accepted” manuscriptThe present work has explored bioactive glass nanoparticles (BGNPs) and developed strontium-doped nanoparticles (BGNPsSr), envisioning orthopedic strategies compatible with vascularization. The nanoparticles were synthesized by the solâ gel method, achieving a diameter of 55 nm for BGNPs and 75 nm for BGNPsSr, and the inclusion of strontium caused no structural alteration. The nanoparticles exhibited high cytocompatibility for human umbilical vein endothelial cells (HUVECs) and SaOS-2. Additionally, the incorporation of strontium emphasized the tubule networking behavior of HUVECs. Our results demonstrate that the nanoparticle dissolution products encouraged the osteogenic differentiation of human adipose stem cells as it favored the expression of key genes and proteins associated with osteogenic lineage. This effect was markedly enhanced for BGNPsSr, which could prompt stem cell osteogenic differentiation without the typical osteogenic inducers. This study not only supports the hypothesis that BGNPs might play a significant role in osteogenic commitment but also highlights that the designed BGNPsSr is a valuable tool for stem cell â tune-upâ in bone tissue engineering applications.Portuguese Foundation for Science and Technology Foundation (FCT) through the doctoral grant SFRH/BD/73174/2010 of Álvaro Leite and FCT and Fundo Social Europeu através do Programa Operacional do Capital Humano (FSE/POCH), PD/59/2013, for the doctoral grant PD/BD/113802/2015info:eu-repo/semantics/publishedVersionACS PublicationsUniversidade do MinhoLeite, A. J.Gonçalves, A IRodrigues, M. T.Gomes, Manuela E.Mano, J. F.2018-062018-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/58749engLeite A. J., Gonçalves A. I., Rodrigues M. T., Gomes M. E., Mano J. F. Strontium-Doped Bioactive Glass Nanoparticles in Osteogenic Commitment, ACS Appl. Mater. Interfaces, Vol. 10, Issue 27, pp. 23311–23320, doi:10.1021/acsami.8b06154, 20181944-82441944-825210.1021/acsami.8b0615429906095https://pubs.acs.org/doi/abs/10.1021/acsami.8b06154info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:23:46Zoai:repositorium.sdum.uminho.pt:1822/58749Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:17:35.052862Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Strontium Doped Bioactive Glass Nanoparticles in Osteogenic Commitment
title Strontium Doped Bioactive Glass Nanoparticles in Osteogenic Commitment
spellingShingle Strontium Doped Bioactive Glass Nanoparticles in Osteogenic Commitment
Leite, A. J.
hASCs
osteogenic differentiation
Strontium
nanoparticles
bioactivity
osteogenic commitment
sol-gel
solâgel
Ciências Médicas::Biotecnologia Médica
Engenharia e Tecnologia::Biotecnologia Industrial
Science & Technology
title_short Strontium Doped Bioactive Glass Nanoparticles in Osteogenic Commitment
title_full Strontium Doped Bioactive Glass Nanoparticles in Osteogenic Commitment
title_fullStr Strontium Doped Bioactive Glass Nanoparticles in Osteogenic Commitment
title_full_unstemmed Strontium Doped Bioactive Glass Nanoparticles in Osteogenic Commitment
title_sort Strontium Doped Bioactive Glass Nanoparticles in Osteogenic Commitment
author Leite, A. J.
author_facet Leite, A. J.
Gonçalves, A I
Rodrigues, M. T.
Gomes, Manuela E.
Mano, J. F.
author_role author
author2 Gonçalves, A I
Rodrigues, M. T.
Gomes, Manuela E.
Mano, J. F.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Leite, A. J.
Gonçalves, A I
Rodrigues, M. T.
Gomes, Manuela E.
Mano, J. F.
dc.subject.por.fl_str_mv hASCs
osteogenic differentiation
Strontium
nanoparticles
bioactivity
osteogenic commitment
sol-gel
solâgel
Ciências Médicas::Biotecnologia Médica
Engenharia e Tecnologia::Biotecnologia Industrial
Science & Technology
topic hASCs
osteogenic differentiation
Strontium
nanoparticles
bioactivity
osteogenic commitment
sol-gel
solâgel
Ciências Médicas::Biotecnologia Médica
Engenharia e Tecnologia::Biotecnologia Industrial
Science & Technology
description “Just Accepted” manuscript
publishDate 2018
dc.date.none.fl_str_mv 2018-06
2018-06-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/58749
url http://hdl.handle.net/1822/58749
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Leite A. J., Gonçalves A. I., Rodrigues M. T., Gomes M. E., Mano J. F. Strontium-Doped Bioactive Glass Nanoparticles in Osteogenic Commitment, ACS Appl. Mater. Interfaces, Vol. 10, Issue 27, pp. 23311–23320, doi:10.1021/acsami.8b06154, 2018
1944-8244
1944-8252
10.1021/acsami.8b06154
29906095
https://pubs.acs.org/doi/abs/10.1021/acsami.8b06154
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv ACS Publications
publisher.none.fl_str_mv ACS Publications
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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