The regulation of IL-10 production by immune cells

Detalhes bibliográficos
Autor(a) principal: Saraiva, Margarida
Data de Publicação: 2010
Outros Autores: O'Garra, Anne
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/29592
Resumo: Interleukin-10 (IL-10), a cytokine with anti-inflammatory properties, has a central role in infection by limiting the immune response to pathogens and thereby preventing damage to the host. Recently, an increasing interest in how IL10 expression is regulated in different immune cells has revealed some of the molecular mechanisms involved at the levels of signal transduction, epigenetics, transcription factor binding and gene activation. Understanding the specific molecular events that regulate the production of IL-10 will help to answer the remaining questions that are important for the design of new strategies of immune intervention.
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spelling The regulation of IL-10 production by immune cellsScience & TechnologyInterleukin-10 (IL-10), a cytokine with anti-inflammatory properties, has a central role in infection by limiting the immune response to pathogens and thereby preventing damage to the host. Recently, an increasing interest in how IL10 expression is regulated in different immune cells has revealed some of the molecular mechanisms involved at the levels of signal transduction, epigenetics, transcription factor binding and gene activation. Understanding the specific molecular events that regulate the production of IL-10 will help to answer the remaining questions that are important for the design of new strategies of immune intervention.Nature Publishing GroupUniversidade do MinhoSaraiva, MargaridaO'Garra, Anne2010-032010-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/29592eng1474-173310.1038/nri271120154735info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:27:00ZPortal AgregadorONG
dc.title.none.fl_str_mv The regulation of IL-10 production by immune cells
title The regulation of IL-10 production by immune cells
spellingShingle The regulation of IL-10 production by immune cells
Saraiva, Margarida
Science & Technology
title_short The regulation of IL-10 production by immune cells
title_full The regulation of IL-10 production by immune cells
title_fullStr The regulation of IL-10 production by immune cells
title_full_unstemmed The regulation of IL-10 production by immune cells
title_sort The regulation of IL-10 production by immune cells
author Saraiva, Margarida
author_facet Saraiva, Margarida
O'Garra, Anne
author_role author
author2 O'Garra, Anne
author2_role author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Saraiva, Margarida
O'Garra, Anne
dc.subject.por.fl_str_mv Science & Technology
topic Science & Technology
description Interleukin-10 (IL-10), a cytokine with anti-inflammatory properties, has a central role in infection by limiting the immune response to pathogens and thereby preventing damage to the host. Recently, an increasing interest in how IL10 expression is regulated in different immune cells has revealed some of the molecular mechanisms involved at the levels of signal transduction, epigenetics, transcription factor binding and gene activation. Understanding the specific molecular events that regulate the production of IL-10 will help to answer the remaining questions that are important for the design of new strategies of immune intervention.
publishDate 2010
dc.date.none.fl_str_mv 2010-03
2010-03-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/29592
url http://hdl.handle.net/1822/29592
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1474-1733
10.1038/nri2711
20154735
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.mail.fl_str_mv
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